Intermediate dose cidofovir does not cause additive nephrotoxicity in BK virus allograft nephropathy

Pediatric Transplantation

Volumn 12, Issue 7, 2008, Pages 790-795

  Araya, Carlos E ^a,b   Lew, Judy F ^b   Fennell, Robert S ^b   Neiberger, Richard E ^b   Dharnidharka, Vikas R ^a,b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

BK virus; Cidofovir; Kidney transplant; Nephrotoxicity; Pediatrics

Indexed keywords

CIDOFOVIR; CREATININE; CYCLOSPORIN A; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; VIRUS DNA;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; ADULT; ARTICLE; BK VIRUS; BK VIRUS ALLOGRAFT NEPHROPATHY; CHILD; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; DNA DETERMINATION; DRUG DOSE REDUCTION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; MALE; NEPHROTOXICITY; POLYMERASE CHAIN REACTION; VIRUS DETECTION; VIRUS LOAD;

ADOLESCENT; ADULT; ANTIVIRAL AGENTS; BK VIRUS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CYTOSINE; DISEASE PROGRESSION; FEMALE; HUMANS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; PHOSPHONIC ACIDS; RETROSPECTIVE STUDIES;

EID: 53849133082     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2008.00937.x     Document Type: Article

References (30)

1. Nickeleit V, Mihatsch MJ. Polyomavirus nephropathy in native kidneys and renal allografts: An update on an escalating threat. Transpl Int 2006 : 19 : 960 973.
2. Smith JM, Dharnidharka VR, Talley L, Martz K, McDonald RA. BK virus nephropathy in pediatric renal transplant recipients: An analysis of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) registry. Clin J Am Soc Nephrol 2007 : 2 : 1037 1042.
3. Trofe J, Hirsch HH, Ramos E. Polyomavirus-associated nephropathy: Update of clinical management in kidney transplant patients. Transpl Infect Dis 2006 : 8 : 76 85.
4. Ramos E, Drachenberg CB, Portocarrero M, et al. BK virus nephropathy diagnosis and treatment: Experience at the University of Maryland Renal Transplant Program. Clin Transplant 2002 : 14 : 143 153.
5. Womer KL, Guerra G, Dibadj K, et al. Immunosuppression reduction for BK virus nephropathy: A case for caution. Transpl Infect Dis 2007 : 9 : 244 248.
6. Josephson MA, Williams JW, Chandraker A, Randhawa PS. Polyomavirus-associated nephropathy: Update on antiviral strategies. Transpl Infect Dis 2006 : 8 : 95 101.
7. De Clercq E. Therapeutic potential of Cidofovir (HPMPC, Vistide) for the treatment of DNA virus (i.e. herpes-, papova-, pox- and adenovirus) infections. Verh K Acad Geneeskd Belg 1996 : 58 : 19 47.
8. Araya CE, Lew JF, Fennell RS III, Neiberger RE, Dharnidharka VR. Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy. Pediatr Transplant 2006 : 10 : 32 37.
9. Racusen LC, Halloran PF, Solez K. Banff 2003 meeting report: New diagnostic insights and standards. Am J Transplant 2004 : 4 : 1562 1566.
10. Reploeg MD, Storch GA, Clifford DB. BK virus: A clinical review. Clin Infect Dis 2001 : 33 : 191 202.
11. Heritage J, Chesters PM, McCance DJ. The persistence of papovavirus BK DNA sequences in normal human renal tissue. J Med Virol 1981 : 8 : 143 150.
12. Gardner SD, Field AM, Coleman DV, Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1971 : 1 : 1253 1257.
13. Brennan DC, Agha I, Bohl DL, et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 2005 : 5 : 582 594.
14. Mengel M, Marwedel M, Radermacher J, et al. Incidence of polyomavirus-nephropathy in renal allografts: Influence of modern immunosuppressive drugs. Nephrol Dial Transplant 2003 : 18 : 1190 1196.
15. Hirsch HH, Knowles W, Ickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002 : 347 : 488 496.
16. Awadalla Y, Randhawa P, Ruppert K, Zeevi A, Duquesnoy RJ. HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients. Am J Transplant 2004 : 4 : 1691 1696.
17. Sachdeva MS, Nada R, Jha V, Sakhuja V, Joshi K. The high incidence of BK polyoma virus infection among renal transplant recipients in India. Transplantation 2004 : 77 : 429 431.
18. Lipshutz GS, Flechner SM, Govani MV, Vincenti F. BK nephropathy in kidney transplant recipients treated with a calcineurin inhibitor-free immunosuppression regimen. Am J Transplant 2004 : 4 : 2132 2134.
19. Randhawa PS, Gupta G, Vats A, Shapiro R, Viscidi RP. Immunoglobulin G, A, and M responses to BK virus in renal transplantation. Clin Vaccine Immunol 2006 : 13 : 1057 1063.
20. Fogeda M, Munoz P, Luque A, Morales MD, Bouza E. Cross-sectional study of BK virus infection in pediatric kidney transplant recipients. Pediatr Transplant 2007 : 11 : 394 401.
21. Acott PD, Hirsch HH. BK virus infection, replication, and diseases in pediatric kidney transplantation. Pediatr Nephrol 2007 : 22 : 1243 1250.
22. Bohl DL, Brennan DC. BK virus nephropathy and kidney transplantation. Clin J Am Soc Nephrol 2007 : 2 : S36 S46.
23. Randhawa P, Farasati NA, Shapiro R, Hostetler KY. Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro. Antimicrob Agents Chemother 2006 : 50 : 1564 1566.
24. Savona MR, Newton D, Frame D, Levine JE, Mineishi S, Kaul DR. Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant. Bone Marrow Transplant 2007 : 39 : 783 787.
25. Lalezari JP, Holland GN, Kramer F, et al. Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1998 : 17 : 339 344.
26. Andrei G, Fiten P, Goubau P, et al. Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient. Transpl Infect Dis 2007 : 9 : 126 131.
27. Keller LS, Peh CA, Nolan J, Bannister KM, Clarkson AR, Faull RJ. BK transplant nephropathy successfully treated with cidofovir. Nephrol Dial Transplant 2003 : 18 : 1013 1014.
28. Lim WH, Mathew TH, Cooper JE, Bowden S, Russ GR. Use of cidofovir in polyomavirus BK viral nephropathy in two renal allograft recipients. Nephrology (Carlton) 2003 : 8 : 318.
29. Kadambi PV, Josephson MA, Williams J, et al. Treatment of refractory BK virus-associated nephropathy with cidofovir. Am J Transplant 2003 : 3 : 186 191.
30. Vats A, Shapiro R, Singh Randhawa P, et al. Quantitative viral load monitoring and cidofovir therapy for the management of BK virus-associated nephropathy in children and adults. Transplantation 2003 : 75 : 105 112.