Electroacupuncture decreases nitric oxide synthesis in the hypothalamus of spontaneously hypertensive rats

Neuroscience Letters

Volumn 446, Issue 2-3, 2008, Pages 78-82

  Kim, Jong In ^a   Kim, Yong Suk ^b   Kang, Sung Keel ^b   Kim, Changhwan ^b   Park, Chan ^c   Lee, Myeong Soo ^a   Huh, Youngbuhm ^c  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Kyung Hee University   (South Korea)

^c Biomedical Science Institute   (South Korea)

Author keywords

Electroacupuncture; Hypothalamus; NADPH diaphorase; Neuronal nitric oxide synthase

Indexed keywords

NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; ELECTROACUPUNCTURE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC FUNCTION;

ANIMALS; BLOOD PRESSURE; CELL COUNT; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ELECTROACUPUNCTURE; ENZYME ACTIVATION; HOMEOSTASIS; HYPERTENSION; HYPOTHALAMUS; IMAGE CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALE; NADPH DEHYDROGENASE; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, INBRED SHR; STAINING AND LABELING; TREATMENT OUTCOME;

EID: 53849128140     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.09.049     Document Type: Article

References (25)

1. Burke R.E., Cadet J.L., Kent J.D., Karanas A.L., and Jackson-Lewis V. An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats. J. Neurosci. Meth. 35 (1990) 63-73
2. Cho Z.H., Hwang S.C., Wong E.K., Son Y.D., Kang C.K., Park T.S., Bai S.J., Kim Y.B., Lee Y.B., Sung K.K., Lee B.H., Shepp L.A., and Min K.T. Neural substrates, experimental evidences and functional hypothesis of acupuncture mechanisms. Acta Neurol. Scand. 113 (2006) 370-377
3. Ernst M., and Lee M.H. Sympathetic effects of manual and electrical acupuncture of the Tsusanli knee point: comparison with the Hoku hand point sympathetic effects. Exp. Neurol. 94 (1986) 1-10
4. Gerova M., Masanova C., and Pavlasek J. Inhibition of NO synthase in the posterior hypothalamus increases blood pressure in the rat. Physiol. Res. 44 (1995) 131-134
5. Han J.S. Acupuncture and endorphins. Neurosci. Lett. 361 (2004) 258-261
6. He Y., Imam S.Z., Dong Z., Jankovic J., Ali S.F., Appel S.H., and Le W. Role of nitric oxide in rotenone-induced nigro-striatal injury. J. Neurochem. 86 (2003) 1338-1345
7. Huang Y.L., Fan M.X., Wang J., Li L., Lu N., Cao Y.X., Shen L.L., and Zhu D.N. Effects of acupuncture on nNOS and iNOS expression in the rostral ventrolateral medulla of stress-induced hypertensive rats. Acupunct. Electrother. Res. 30 (2005) 263-273
8. Kim Y.S., Kim C., Kang M., Yoo J., and Huh Y. Electroacupuncture-related changes of NADPH-diaphorase and neuronal nitric oxide synthase in the brainstem of spontaneously hypertensive rats. Neurosci. Lett. 312 (2001) 63-66
9. Knardahl S., Elam M., Olausson B., and Wallin B.G. Sympathetic nerve activity after acupuncture in humans. Pain 75 (1998) 19-25
10. Krukoff T.L. Central actions of nitric oxide in regulation of autonomic functions. Brain Res. Brain Res. Rev. 30 (1999) 52-65
11. Kuo H., Grant S., Muth N., Hengemihle J., and Ingram D.K. The correlation between neuron counts and optical density of NADPH-diaphorase histochemistry in the rat striatum: a quantitative study. Brain Res. 660 (1994) 57-65
12. Li Z., Wang C., Mak A.F., and Chow D.H. Effects of acupuncture on heart rate variability in normal subjects under fatigue and non-fatigue state. Eur. J. Appl. Physiol. 94 (2005) 633-640
13. Liao J.M., Ting H., Lee S.D., Yang C.H., Liou Y.M., Peng M.L., Tsai S.J., Lin C.F., and Lin T.B. Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats. Auton. Neurosci. 124 (2006) 18-25
14. Lin T.B., Fu T.C., Chen C.F., Lin Y.J., and Chien C.T. Low and high frequency electroacupuncture at Hoku elicits a distinct mechanism to activate sympathetic nervous system in anesthetized rats. Neurosci. Lett. 247 (1998) 155-158
15. Lundin S., Ricksten S.E., and Thoren P. Renal sympathetic activity in spontaneously hypertensive rats and normotensive controls, as studied by three different methods. Acta Physiol. Scand. 120 (1984) 265-272
16. Ma S.X., Ma J., Moise G., and Li X.Y. Responses of neuronal nitric oxide synthase expression in the brainstem to electroacupuncture Zusanli (ST 36) in rats. Brain Res. 1037 (2005) 70-77
17. Napadow V., Dhond R.P., Purdon P., Kettner N., Makris N., Kwong K.K., and Hui K.K. Correlating acupuncture FMRI in the human brainstem with heart rate variability. Conf. Proc. IEEE Eng. Med. Biol. Soc. 5 (2005) 4496-4499
18. Nishijo K., Mori H., Yosikawa K., and Yazawa K. Decreased heart rate by acupuncture stimulation in humans via facilitation of cardiac vagal activity and suppression of cardiac sympathetic nerve. Neurosci. Lett. 227 (1997) 165-168
19. Plochocka-Zulinska D., and Krukoff T.L. Increased gene expression of neuronal nitric oxide synthase in brain of adult spontaneously hypertensive rats. Brain Res. Mol. Brain Res. 48 (1997) 291-297
20. Sato A., Sato Y., and Suzuki A. Mechanism of the reflex inhibition of micturition contractions of the urinary bladder elicited by acupuncture-like stimulation in anesthetized rats. Neurosci. Res. 15 (1992) 189-198
21. Tseng C.J., Liu H.Y., Lin H.C., Ger L.P., Tung C.S., and Yen M.H. Cardiovascular effects of nitric oxide in the brain stem nuclei of rats. Hypertension 27 (1996) 36-42
22. Vincent S.R., and Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46 (1992) 755-784
23. Wu M.T., Hsieh J.C., Xiong J., Yang C.F., Pan H.B., Chen Y.C., Tsai G., Rosen B.R., and Kwong K.K. Central nervous pathway for acupuncture stimulation: localization of processing with functional MR imaging of the brain-preliminary experience. Radiology 212 (1999) 133-141
24. Yu K.L., Tamada Y., Suwa F., Fang Y.R., and Tang C.S. Age-related changes in oxytocin-, arginine vasopressin- and nitric oxide synthase-expressing neurons in the supraoptic nucleus of the rat. Life Sci. 78 (2006) 1143-1148
25. Zanzinger J., Czachurski J., and Seller H. Effects of nitric oxide on sympathetic baroreflex transmission in the nucleus tractus solitarii and caudal ventrolateral medulla in cats. Neurosci. Lett. 197 (1995) 199-202