Does low dose hydrocortisone reduce mortality in septic shock?

National Medical Journal of India

Volumn 21, Issue 3, 2008, Pages 128-129

  Singh, Georgene ^a   Sen, Nagamani ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; PLACEBO; TETRACOSACTIDE; VASOPRESSIN;

CLINICAL TRIAL; CORTICOTROPIN TEST; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; HUMAN; HYPERGLYCEMIA; HYPERNATREMIA; INTENSIVE CARE UNIT; LENGTH OF STAY; LOW DRUG DOSE; MORTALITY; SEPTIC SHOCK; SHORT SURVEY; SUPERINFECTION;

EID: 53849123316     PISSN: 0970258X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (10)

1. Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987; 317:653-8.
2. The Veterans Administration Systemic Sepsis Cooperative Study Group. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987; 317:659-65.
3. Oppert M, Schindler R, Husung C, Offermann K, Gräf KJ, Boenisch O, et al. Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005;33:2457-64.
4. Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862-71.
5. Zijlstra JG, van der Horst IC, Tulleken JE, van der Werf TS, Ligtenberg JJ, et al. Corticosteroids for patients with septic shock. JAMA 2OO3;289:42; author reply 43-4.
6. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for treating severe sepsis and septic shock. Cochrane Database Syst Rev 2004;1: CD002243.
7. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 2004;30:536-55. Epub 2004 Mar 3.
8. Rai R, Cohen J, Venkatesh B. Assessment of adrenocortical function in the critically ill. Crit Care Resusc 2004;6:123-9.
9. Finfer S. Corticosteroids in septic shock. N Engl J Med 2008; 358:188-90.
10. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327.