Successful intrathecal baclofen therapy for seronegative stiff-person syndrome: A case report

Acta Neurologica Taiwanica

Volumn 17, Issue 3, 2008, Pages 172-176

  Ho, Bo Lin ^a   Shih, Pang Ying ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Anti glutamic acid decarboxylase antibodies; Intrathecal baclofen therapy; Stiff person syndrome

Indexed keywords

BACLOFEN; DIAZEPAM; GLUTAMATE DECARBOXYLASE ANTIBODY; LEVODOPA; PREDNISOLONE;

ADULT; ARTICLE; CASE REPORT; DRUG DOSE TITRATION; ELECTROMYOGRAPHY; EVOKED MUSCLE RESPONSE; FATIGUE; GAIT DISORDER; HUMAN; LORDOSIS; MALE; MUSCLE CRAMP; MUSCLE RIGIDITY; MUSCLE SPASM; MUSCLE STIFFNESS; NEUROLOGIC EXAMINATION; PARKINSONISM; PLASMAPHERESIS; REFLEX DISORDER; SERODIAGNOSIS; SINGLE DRUG DOSE; SPASTICITY; STIFF MAN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; TREMOR; UNSPECIFIED SIDE EFFECT;

ADULT; AUTOANTIBODIES; BACLOFEN; GLUTAMATE DECARBOXYLASE; HUMANS; INJECTIONS, SPINAL; MALE; STIFF-PERSON SYNDROME;

EID: 53849110661     PISSN: 10196099     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Meinck HM, Thompson PD. Stiff man syndrome and related conditions. Mov Disord 2002;17:853-66.
2. Solimena M, Folli F, Aparisi R, et al. Autoantibodies to GAB-Aergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 1990;322:1555-60.
3. Barker RA, Revesz T, Thom M, et al. Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity. J Neurol Neurosurg Psychiatry 1998;65:633-40.
4. Chang YJ, Wu CL, Lu CS. Stiff-man syndrome: report of a case. J Formos Med Assoc 1995;94:695-7.
5. Stayer C, Tronnier V, Dressnandt J, et al. Intrathecal baclofen therapy for stiff-man syndrome and progressive encephalomyelopathy with rigidity and myoclonus. Neurology 1997;49:1591-7.
6. Penn RD, Mangieri EA. Stiff-man syndrome treated with intrathecal baclofen. Neurology 1993;43:2412.
7. Silbert PL, Matsumoto JY, McManis PG, et al. Intrathecal baclofen therapy in stiff-man syndrome: a double-blind, placebo-controlled trial. Neurology 1995;45:1893-7.
8. Espay AJ, Chen R. Rigidity and spasms from autoimmune encephalomyelopathies: stiff-person syndrome. Muscle Nerve 2006;34:677-90.
9. Saiz A, Arpa J, Sagasta A, et al. Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity. Neurology 1997;49:1026-30.
10. Dalakas MC, Fujii M, Li M, et al. The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology 2000;55:1531-5.
11. Meinck HM, Ricker K, Hulser PJ, et al. Stiff man syndrome: clinical and laboratory findings in eight patients. J Neurol 1994;241:157-66.
12. Brown P, Marsden CD. The stiff man and stiff man plus syndromes. J Neurol 1999;246:648-52.
13. Brown P. Stiffness with continuous motor unit activity. Movement Disorders, Handbook of Clinical Neurophysiology, Vol. 1. Amsterdam: Elsevier, 2003:463-75.
14. Jankovic J, Fahn S. Dystonic disorders. Parkinson's Disease and Movement Disorders, 2nd ed. Baltimore: Williams & Wilkins, 1993:337-74.
15. Vianello M, Tavolato B, Giometto B. Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurol Sci 2002;23:145-51.
16. Murinson BB, Butler M, Marfurt K, et al. Markedly elevated GAD antibodies in SPS: effects of age and illness duration. Neurology 2004;63:2146-8.
17. Shariatmadar S, Noto TA. Plasma exchange in stiff-man syndrome. Ther Apher 2001;5:64-7.
18. Rakocevic G, Raju R, Dalakas MC. Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severity. Arch Neurol 2004;61:902-4.
19. Meinck HM. Stiff man syndrome. CNS Drugs 2001; 15:515-26.
20. Bardutzky J, Tronnier V, Schwab S, et al. Intrathecal baclofen for stiff-person syndrome: life-threatening intermittent catheter leakage. Neurology 2003;60:1976-8.