Differential induction of apoptosis and inhibition of the PI3-kinase pathway by saturated, monounsaturated and polyunsaturated fatty acids in a colon cancer cell model

Apoptosis

Volumn 13, Issue 11, 2008, Pages 1368-1377

  Engelbrecht, Anna Mart ^a   Toit Kohn, Joe Lin Du ^a   Ellis, Beverly ^a   Thomas, Mark ^a   Nell, Theo ^a   Smith, Rob ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Apoptosis; Colon cancer; Fatty acids; Phosphoinositide 3 kinase; Protein kinase B Akt

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; OLEIC ACID; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CHEMOPROPHYLAXIS; COLON CANCER; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CACO-2 CELLS; CELL LINE, TUMOR; CELL SURVIVAL; COLON; COLONIC NEOPLASMS; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS; FATTY ACIDS, UNSATURATED; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 53849103579     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0260-3     Document Type: Article

References (41)

1. EJ Kim PE Holthuizen HS Park YL Ha KC Jung JHY Park 2002 Trans-10, cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth Am J Physiol Gastrointest Liver Physiol 283 G357 G367
2. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 57 70 10.1016/S0092-8674(00)81683-9
3. KM Nicholson NG Anderson 2002 The protein kinase B/Akt signaling pathway in human malignancy Cell Signal 14 381 395 10.1016/S0898-6568(01)00271-6
4. S Sato N Fujita T Tsururo 2004 Involvement of 3-phosphoinositide- dependent protein kinase-1 in the MEK/MAPK signal transduction pathway J Biol Chem 279 33759 33767 10.1074/jbc.M402055200
5. J Luo BD Manning LC Cantley 2003 Targeting the PI3-K-Akt pathway in human cancer: rationale and promise Cancer Cell 4 257 262 10.1016/S1535-6108(03) 00248-4
6. L Stephens R Williams P Hawkins 2005 Phosphoinositide 3-kinases as drug targets in cancer Curr Opin Pharmacol 5 357 365 10.1016/j.coph.2005.03.002
7. I Vivanco CL Sawyers 2002 The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat Rev Cancer 2 489 501 10.1038/nrc839
8. JJ Zhao H Cheng J Shidong 2006 The p110α isoform of PI3-K is essential for proper growth factor signaling and oncogenic transformation Proc Natl Acad Sci USA 103 16296 16300 10.1073/pnas.0607899103
9. K Inoki T Zhu KL Guan 2003 TSC2 mediates cellular energy response to control cell growth and survival Cell 115 577 590 10.1016/S0092-8674(03)00929-2
10. DP Rose JM Connolly 1993 Effects of dietary omega-3 fatty acids on human breast cancer growth and metastasis in nude mice J Natl Cancer Inst 85 1743 1747 10.1093/jnci/85.21.1743
11. JM Connolly M Coleman DP Rose 1997 Effects of dietary fatty acids on DU145 human prostate cancer cell growth in athymic nude mice Nutr Cancer 29 114 119
12. JL Nano C Nobili F Girard-Pipau 2003 Effects of fatty acids on the growth of Caco-2 cells Prostaglandins Leukot Essent Fatty Acids 69 207 215 10.1016/S0952-3278(03)00083-8
13. ZY Chen NW Istfan 2000 Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells Prostaglandins Leukot Essent Fatty Acids 63 5 301 10.1054/plef.2000.0218
14. J Folch M Lees GHS Stanley 1957 A simple method for the isolation and purification of total lipids from animal tissues J Biol Chem 226 497 509
15. SS Zail A Pickering 1979 Fatty acid composition of erythrocytes in hereditary sherocytosis Br J Haematol 42 339 402 10.1111/j.1365-2141.1979. tb01148.x
16. WR Morrison LM Smith 1964 Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride methanol J Lipid Res 5 600 608
17. LA Gomez AE Alekseev LA Aleksandrova PA Brady A Terzic 1997 Use of MTT Assay in adult ventricular cardiomyocytes to assess viability: effects of adenosine and potassium on cellular survival Mol Cell Cardiol 29 1255 1266 10.1006/jmcc.1996.0363
18. MM Bradford 1976 A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 71 248 254 10.1016/0003-2697(76)90527-3
19. AA Spector MA Yorek 1985 Membrane lipid composition and cellular function J Lipid Res 26 1015 1035
20. J-L Nano C Nobili F Girard-Pipau P Rampal 2003 Effects of fatty acids on the growth of Caco-2 cells Prostaglandins Leukot Essent Fatty Acids 69 207 215 10.1016/S0952-3278(03)00083-8
21. JM Ntambi 1999 Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol J Lipid Res 40 1549 1558
22. MP Wymann M Zvelebil M Laffargue 2003 Phosphoinositide 3-kinase signaling-which way to target? Trends Pharmacol 24 366 376 10.1016/S0165- 6147(03)00163-9
23. A Cataldi G Zauli R Di Pietro 2001 Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation Cell Signal 3 369 375 10.1016/S0898-6568(01) 00147-4
24. SG Kennedy AJ Wagner SD Conzen 1997 The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal Genes Dev 11 701 713 10.1101/gad.11.6.701
25. KM Nicholson NG Anderson 2002 The protein kinase B/Akt signaling pathway in human malignancy Cell Signal 14 381 395 10.1016/S0898-6568(01)00271-6
26. NR Leslie CP Downes 2004 PTEN function: how normal cells control it and tumor cells lose it Biochem J 382 709 713
27. F Vazquez SR Ramaswamy N Nakamura WR Seller 2000 Phosphorylation of the PTEN tail regulates protein stability and function Mol Cell Biol 20 5010 5018 10.1128/MCB.20.14.5010-5018.2000
28. X Wu K Senechal MS Neshat YE Wang CL Sawyers 1998 The PTEN/MMAC tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway Proc Natl Acad Sci USA 95 15587 15591 10.1073/pnas.95.26. 15587
29. SR James CP Downes R Giggs SJ Grove AB Holmes DR Alessi 1996 Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3, 4, 5-triphosphate without subsequent activation Biochem J 315 709 713
30. DR Alessi M Andjelkovic B Caudwell P Cron N Morrice P Cohen 1996 Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J 23 6541 6551
31. MP Scheid JR Woodgett 2001 PKB/AKT: functional insights from genetic models Nat Rev Mol Cell Biol 2 760 768 10.1038/35096067
32. JA Fresno Vara E Casado J de Castro P Cejas C Belda-Inietsa M Gonzalez-Baron 2004 PI3-K/Akt signaling pathway and cancer Cancer Treat Rev 30 193 204 10.1016/j.ctrv.2003.07.007
33. WH Biggs J Meisenhelder T Hunter WK Cavenee KC Arden 1999 Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 Proc Natl Acad Sci USA 96 7421 7426 10.1073/pnas.96.13.7421
34. G Rena S Guo SC Cichy TG Unterman P Cohen 1999 Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B J Biol Chem 24 17179 17183 10.1074/jbc.274.24.17179
35. A Brunet A Bonni MJ Zigmond 1999 Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor Cell 6 857 868 10.1016/S0092-8674(00)80595-4
36. WH Zheng S Kar R Quirion 2002 Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells J Biol Chem 75 39152 39154
37. T Skorski A Bellacosa M Nieborowska-Skorska 1997 Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway EMBO J 20 6151 6161 10.1093/emboj/16.20.6151
38. S Pugazhenthi A Nesterova C Sable 2000 Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein J Biol Chem 15 10761 10766 10.1074/jbc.275.15.10761
39. Y Tan MR Demeter H Ruan MJ Comb 2000 BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival J Biol Chem 275 25865 25869 10.1074/jbc.M004199200
40. SR Shaikh AC Dumaul LJ Jenski W Stillwell 2001 Lipid phase separation in phospholipid bilayers and monolayers modeling the plasma membrane Biochim Biophys Acta 1512 317 328 10.1016/S0005-2736(01)00335-2
41. R Goswami D Singh G Phillips J Kilkus G Dawson 2005 Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines J Neurosci Res 81 4 541 550 10.1002/jnr.20550