(3S)-N-(l-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: Synthesis, bioassay, 3D QSAR, and ADME analysis

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9574-9587

  Zheng, Meiqing ^a   Zhang, Xiaoyi ^a   Zhao, Ming ^a   Chang, Heng Wei ^b   Wang, Wei ^b   Wang, Yuji ^a   Peng, Shiqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b C S Bio Company   (United States)

Author keywords

3D QSAR; ADMET; Amino acid; Antithrombotic; Tetrahydroisoquinoline

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; AMINO ACID DERIVATIVE; ANTICOAGULANT AGENT; ARACHIDONIC ACID; DIPEPTIDE DERIVATIVE; N (SERINYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; SERINE; TETRAHYDROISOQUINOLINE 3 CARBOXYAMINO ACID; TETRAHYDROISOQUINOLINE DERIVATIVE; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; MALE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STEREOSPECIFICITY; THROMBOCYTE AGGREGATION; THROMBOGENESIS;

ADENOSINE DIPHOSPHATE; ANIMALS; ARACHIDONIC ACID; BIOLOGICAL ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOLYTIC AGENTS; MOLECULAR STRUCTURE; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; TETRAHYDROISOQUINOLINES; THROMBIN;

RATTUS;

EID: 53749094517     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.019     Document Type: Article

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