Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5448-5450

  Wei, Xiaomei ^a   Rodríguez, Abimael D ^a   Wang, Yuehong ^b   Franzblau, Scott G ^b  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Abeo sterols; Cytotoxicity; Mycobacterium tuberculosis; Synthesis; Tuberculosis

Indexed keywords

CHOLESTANE DERIVATIVE; CYCLOPENTANE; RIFAMPICIN; STEROL DERIVATIVE; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITUBERCULAR AGENTS; CHEMISTRY, PHARMACEUTICAL; CHOLESTANES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PORIFERA; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 53649108932     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.029     Document Type: Article

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