The ratio of late-follicular to mid-follicular phase LH concentrations efficiently predicts ART outcomes in women undergoing ART treatment with GnRH-agonist long protocol and stimulation with recombinant FSH

Journal of Assisted Reproduction and Genetics

Volumn 25, Issue 8, 2008, Pages 359-364

  Nakagawa, Koji ^a   Ohgi, Shirei ^a   Nakashima, Akira ^a   Horikawa, Takashi ^a   Sugiyama, Rikikazu ^b   Saito, Hidekazu ^a  

^a NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b Sugiyama Clinic   (Japan)

Author keywords

ART outcome; GnRH agonist; LH concentration; Long protocol; Pregnancy rate; Recombinant FSH

Indexed keywords

BUSERECUR; BUSERELIN ACETATE; CHORIONIC GONADOTROPIN; ESTRADIOL; ESTROGEN; FOLLITROPIN; HYDROXYPROGESTERONE CAPROATE; LUTEINIZING HORMONE; PROGESTERONE; RECOMBINANT FOLLITROPIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL PROTOCOL; EMBRYO; EMBRYO TRANSFER; ENDOMETRIOSIS; ESTRADIOL BLOOD LEVEL; FEMALE; FEMALE INFERTILITY; FERTILIZATION; FERTILIZATION IN VITRO; FOLLICULAR PHASE; FOLLITROPIN BLOOD LEVEL; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LUTEAL PHASE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; NIDATION; OVARY HYPERSTIMULATION; OVULATION INDUCTION; PREGNANCY RATE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SUPPLEMENTATION; TREATMENT DURATION; TREATMENT OUTCOME;

ADULT; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; FOLLICULAR PHASE; GONADOTROPIN-RELEASING HORMONE; HUMANS; LUTEINIZING HORMONE; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; REPRODUCTIVE TECHNIQUES, ASSISTED; SPERM INJECTIONS, INTRACYTOPLASMIC; TREATMENT OUTCOME;

EID: 53649083561     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10815-008-9243-0     Document Type: Article

References (18)

1. L Wildt K Diedrich H van der Ven S al Hasani H Hubner R Klasen 1986 Ovarian hyperstimulation for in-vitro fertilization controlled by GnRH agonist administered in combination with human menopausal gonadotrophins Hum Reprod. 1 15 19
2. P Devroy B Mannaerts J Smitz H Coelingh Bennink A Van Steirteghem 1994 Clinical outcome of a pilot efficacy study on recombinant human follicle-stimulating hormone (Org 32489) combined with various gonadotropin-releasing hormone agonist regimens Hum Reprod. 9 1064 1069
3. RA Cabrera L Stadtmauer JF Mayer WE Gibbons S Oehninger 2005 Follicular phase serum levels of luteinizing hormone do not influence delivery rates in in vitro fertilization cycles down-regulated with a gonadotropin-releasing hormone agonist and stimulated with recombinant follicle-stimulating hormone Fertil Steril. 83 42 48 doi:10.1016/j.fertnstert.2004.06.050
4. EM Kolibianakis J Collins B Tarlatzis E Papanikolous P Devroy 2006 Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review Hum Reprod Update. 12 3 12 doi:10.1093/humupd/dmi030
5. R Fleming F Lloyd M Herbert J Fenwick T Griffiths A Murdoch 1998 Effects of profound suppression of luteinizing hormone during ovarian stimulation on follicular activity, oocyte and embryo function in cycles stimulated with purified follicle stimulating hormone Hum Reprod. 13 1788 1792 doi:10.1093/humrep/13.7.1788
6. LG Westergaard SB Laursen CY Andersen 2000 Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotrophic women undergoing assisted reproduction Hum Reprod. 15 1003 1008 doi:10.1093/humrep/15.5.1003
7. J Balasch E Vidal J Peñarrubia R Casamitjana F Carmona M Creus 2001 Suppression of LH during ovarian stimulation: analyzing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH Hum Reprod. 16 1636 1643 doi:10.1093/humrep/16.8.1636
8. MA Esposito KT Barnhart C Coutifaris P Patrizio 2001 Role of periovulatory luteinizing hormone concentrations during assisted reproductive technology cycles stimulated exclusively with recombinant follicle-stimulating hormone Fertil Steril. 75 519 524 doi:10.1016/S0015-0282(00)01745-3
9. P Humaidan L Bungum M Bungum CY Andersen 2002 Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation Hum Reprod. 17 2016 2021 doi:10.1093/humrep/17.8.2016
10. P Humaidan M Bungum L Bungum C Yding Andersen 2004 Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH: on opening study Reprod Biomed Online. 8 635 643
11. P Humaidan 2006 To add or not to add LH: comments on a recent commentary Reprod Biomed Online. 12 284 285
12. K Nakagawa S Ohgi R Kojima K Sugawara T Horikawa M Ito M I Irahara H Saito 2007 Recombinant-FSH has more effective potent than urinary human menopausal gonadotropin in ovarian hyperstimulation for ART treatment Reprod Med Biol. 6 27 32 doi:10.1111/j.1447-0578.2007.00161.x
13. K Nakagawa S Ohgi R Kojima M Ito T Horikawa M Irahara 2006 Reduction of perifollicular arterial blood flow resistance after hCG administration is a good indicator of the recovery of mature oocytes in ART treatment J Assist Reprod Genet. 23 433 438 doi:10.1007/s10815-006-9087-4
14. K Nakagawa S Yamano N Moride M Yamashita M Yoshizawa T Aono 2001 Effect of activation with Ca ionophore A23187 and puromycin on the development of human oocytes that failed to fertilize after intracytoplasmic sperm injection Fertil Steril. 76 148 152 doi:10.1016/S0015-0282(01)01839-8
15. The European recombinant human LH study group 1998 Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced folliclar development in LH- and FSH-deficient anovulatory women: a dose-finding study J Clin Endocrinol Metab 83 1507 1514 doi:10.1210/jc.83.5.1507
16. Z Shoham A Balen A Patel HS Jacobs 1991 Results of ovulation induction using human menopausal gonadotropin or purified follicle-stimulating hormone in hypogonadotorpic hypogonadism patients Fertil Steril. 56 1048 1053
17. R Lauoud M Al-Jefout J Tyler J Ryan G Driscoll 2006 A relative reduction in mid-follicular LH concentrations during GnRH agonist IVF/ICSI cycles leads to lower live birth rates Hum Reprod. 21 2645 2649 doi:10.1093/humrep/del219
18. S Kol 2005 To add or not to add LH: consideration of LH concentration changes in individual patients Reprod Biomed Online. 11 664 666