Synthesis and biodistribution of 34mCl-labeled 2-chloro-2-deoxy-d-glucose: A major impurity in [18F]FDG injection

Applied Radiation and Isotopes

Volumn 66, Issue 12, 2008, Pages 1905-1909

  Fukumura, Toshimitsu ^a   Takei, Makoto ^a,b   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b Department of Engineering and Environment   (Japan)

Author keywords

34mCl; Biodistribution; K34mCl kryptofix 2.2.2 2 deoxy 2 34mCl chloro deoxy d glucose; Nucleophilic chlorination

Indexed keywords

34MCL; BIODISTRIBUTION; K34MCL/KRYPTOFIX 2.2.2 2-DEOXY-2-[34MCL]CHLORO-DEOXY-D-GLUCOSE; NUCLEOPHILIC CHLORINATION;

1,3,4,6 TETRA O ACETYL 2 TRIFLUOROMETHANESULFONYLMANNOSE; 2 CHLORO 2 DEOXYGLUCOSE CL 34M; ACETIC ACID DERIVATIVE; FLUORODEOXYGLUCOSE F 18; MANNOSE; RADIOPHARMACEUTICAL AGENT; TRIFLUOROMETHANESULFONIC ACID; UNCLASSIFIED DRUG; CHLORINE; DIAGNOSTIC AGENT; RADIOISOTOPE;

ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG IMPURITY; DRUG SYNTHESIS; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTUM YIELD; RADIOCHEMISTRY; RAT; REACTION ANALYSIS; REACTION TIME; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; DRUG CONTAMINATION; METABOLIC CLEARANCE RATE; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; CHLORINE; DRUG CONTAMINATION; FLUORODEOXYGLUCOSE F18; MALE; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; RADIOISOTOPES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 53549131239     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2008.06.042     Document Type: Article

References (15)

1. 34mCl from a gaseous hydrogen sulfide target. Int. J. Appl. Radiat. Isot. 35 (1984) 1045-1048
2. 18FDG preparations and detection of the chemical impurity 2-deoxy-2-chloro-d-glucose. Int. J. Radiat. Appl. Instrum. [A] 43 (1992) 1313-1322
3. Bessell E.M., Foster A.B., and Westwood J.H. The use of deoxyfluoro-d-glucopyranoses and related compounds in a study of yeast hexokinase specificity. Biochem. J. 128 (1972) 199-204
4. Colville C.A., Seatter M.J., and Gould G.W. Analysis of the structural requirements of sugar binding to the liver, brain and insulin-responsive glucose transporters expressed in oocytes. Biochem. J. 294 (1993) 753-760
5. Crane P.D., Pardridge W.M., Braun L.D., and Oldendorf W.H. Kinetics of transport and phosphorylation of 2-fluoro-2-deoxy-d-glucose in rat brain. J. Neurochem. 40 (1983) 160-167
6. 18F]fluoro-2-deoxy-d-glocose using aminopolyether supported nucleophilic substitution. J. Nucl. Med. 27 (1986) 235-238
7. 34mCl for biomedical use. J. Radioanal. Nucl. Lett. 94 (1985) 149-160
8. 18F]fluoro-d-glucose transport and phosphorylation rates in myocardium using dual-tracer kinetic experiments. FEBS Lett. 216 (1987) 128-132
9. + 53%; IT 47%) with proton on natural isotopic chlorine-containing targets. Appl. Radiat. Isot. 43 (1992) 1375-1381
10. 18F]FDG synthesis by alkaline hydrolysis on a low polarity solid phase support. J. Labelled Compds. Radiopharm. 45 (2002) 435-447
11. Machulla H.J., Stöcklin G., Kupfernagel C., Freundlieb C., Hock A., Vyska K., and Feinendegen L.E. Comparative evaluation of fatty acids labeled with C-11, Cl-34 m, Br-77, and I-123 for metabolic studies of the myocardium: concise communication. J. Nucl. Med. 19 (1978) 298-302
12. 18F]FDG injection: bacterial endotoxins test, aluminum ions test and HPLC analysis for FDG and CIDG. Appl. Radiat. Isot. 62 (2005) 889-895
13. Qaim S.M., and Stocklin G. Production of some medically important short-lived neutron-deficient radioisotopes of halogens. Radiochim. Acta 34 (1983) 25-40
14. 32S(α, pn) nuclear reaction. Appl. Radiat. Isot. 65 (2007) 981-986
15. 38Cl produced by various charged particles on phosphorus, sulfur and chlorine targets. Int. J. Appl. Radiat. Isot. 27 (1976) 159-161