The expression of NMDA receptor subunit mRNA in human chronic alcoholics: influence of cirrhosis and genotype

Annals of the New York Academy of Sciences

Volumn 1139, Issue , 2008, Pages 10-19

  Ridge, Justin P ^a   Ho, Ada M C ^a   Innes, David J ^a   Dodd, Peter R ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

5 HTTLPR; Autopsy; Cerebral cortex; Excitotoxicity; Genotype phenotype interactions; Glutamate

Indexed keywords

ALCOHOL; GLUTAMATE RECEPTOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; SEROTONIN TRANSPORTER;

ALCOHOLISM; ALLELE; COMORBIDITY; CONFERENCE PAPER; CONTROLLED STUDY; DNA POLYMORPHISM; EXCITOTOXICITY; FRONTAL CORTEX; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN TISSUE; LIVER CIRRHOSIS; MOTOR CORTEX; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 53549126350     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1432.053     Document Type: Conference Paper

References (34)

1. WHO. 2004. Global Status Report on Alcohol. Department of Mental Health and Substance Abuse, WHO. Geneva.
2. Charness, M.E. 1993. Brain lesions in alcoholics. Alcohol. Clin. Exp. Res. 17 : 2 11.
3. Edenberg, H.J. et al. 2006. Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum. Mol. Genet. 15 : 1539 1549.
4. Feinn, R. et al. 2005. Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am. J. Med. Genet. B Neuropsychiatr. Genet. 133 : 79 84.
5. Wernicke, C. et al. 2003. Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits. Biol. Psychiatry 54 : 922 928.
6. Samochowiec, J. et al. 2006. Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence. Neurosci. Lett. 410 : 1 5.
7. Loh, E.-W. et al. 1999. Association between variants at the GABAAβ2, GABAAα6 and NMDA subunit mRNA in alcoholics GABAAγ2 gene cluster and alcohol dependence in a Scottish population. Mol. Psychiatry 4 : 539 544.
8. Furukawa, H. et al. 2005. Subunit arrangement and function in NMDA receptors. Nature 438 : 185 192.
9. Lerea, L.S. et al. 1995. N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways. Mol. Pharmacol. 47 : 1119 1125.
10. Dodd, P.R. et al. 2000. Glutamate-mediated transmission, alcohol, and alcoholism. Neurochem. Int. 37 : 509 533.
11. Schaffer, A. & C.A. Naranjo. 1998. Recommended drug treatment strategies for the alcoholic patient. Drugs 56 : 571 585.
12. Foley, P.F. et al. 2004. Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. Ann. N.Y. Acad. Sci. 1025 : 39 46.
13. Winer, B.J. et al. 1991. Statistical Principles in Experimental Design. McGraw-Hill. Sydney, NSW.
14. Dodd, P.R. & J.M. Lewohl. 1998. Cell death mediated by amino acid transmitter receptors in human alcoholic brain damage: conflicts in the evidence. Ann. N.Y. Acad. Sci. 844 : 50 58.
15. Snell, L.D. et al. 1993. Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Res. 602 : 91 98.
16. Gulya, K. et al. 1991. Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res. 547 : 129 134.
17. Haugbol, S.R. et al. 2005. Upregulation of glutamate receptor subtypes during alcohol withdrawal in rats. Alcohol Alcohol. 40 : 89 95.
18. Snell, L.D. et al. 1996. Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res. Mol. 40 : 71 78.
19. Iorio, K.R. et al. 1992. Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function. Mol. Pharmacol. 41 : 1142 1148.
20. Darstein, M.B. et al. 2000. Changes in NMDA receptor subunit gene expression in the rat brain following withdrawal from forced long-term ethanol intake. Naunyn-Schmiedeberg's Arch. Pharmacol. 361 : 206 213.
21. Kalev-Zylinska, M.L. & M.J. During. 2007. Paradoxical facilitatory effect of low-dose alcohol consumption on memory mediated by NMDA receptors. J. Neurosci. 27 : 10456 10467.
22. 3H]glutamate binding sites in rat brain following portacaval anastomosis. J. Neurochem. 55 : 386 390.
23. Vaquero, J. & R.F. Butterworth. 2006. The brain glutamate system in liver failure. J. Neurochem. 98 : 661 669.
24. Chan, H. & R.F. Butterworth. 2003. Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain. Neurochem. Int. 43 : 525 532.
25. Mann, R.E. et al. 2003. The epidemiology of alcoholic liver disease. Alcohol Res. Health 27 : 209 219.
26. Dodd, P.R. et al. 2006. Genes and gene expression in the brains of human alcoholics. Ann. N.Y. Acad. Sci. 1074 : 104 115.
27. Heils, A. et al. 1996. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66 : 2261 2264.
28. Munafo, M.R. et al. 2005. Association between the serotonin transporter gene and alcohol consumption in social drinkers. Am. J. Med. Genet. B Neuropsychiatr. Genet. 135 : 10 14.
29. Dick, D.M. et al. 2007. Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Psychiatr. Genet. 17 : 35 38.
30. Kohnke, M.D. et al. 2006. The serotonin transporter promotor polymorphism 5-HTTLPR is not associated with alcoholism or severe forms of alcohol withdrawal in a German sample. Psychiatr. Genet. 16 : 227 228.
31. Nakamura, M. et al. 2000. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol. Psychiatry 5 : 32 38.
32. Hu, X.Z. et al. 2006. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am. J. Hum. Genet. 78 : 815 826.
33. LeMarquand, D. et al. 1994. Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol. Psychiatry 36 : 395 421.
34. Daws, L.C. et al. 2006. Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. J. Neurosci. 26 : 6431 6438.