Emerging drugs for ovarian cancer

Expert Opinion on Emerging Drugs

Volumn 13, Issue 3, 2008, Pages 523-536

  Sugiyama, Toru ^a   Konishi, Ikuo ^b  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Bevacizumab; Biological agents; Carboplatin; Chemotherapeutic agents; Ovarian cancer; Paclitaxel

Indexed keywords

6 HYDROXYMETHYLACYLFULVENE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BORTEZOMIB; BRYOSTATIN; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; DOXORUBICIN; ENZASTAURIN; ETOPOSIDE; GEFITINIB; GEMCITABINE; IMATINIB; INTERLEUKIN 12; IRINOTECAN; KARENITECIN; LAPATINIB; MIFEPRISTONE; N (3,3 DIMETHYL 6 INDOLINYL) 2 (4 PYRIDINYLMETHYLAMINO)NICOTINAMIDE; PACLITAXEL; PACLITAXEL POLIGLUMEX; PYRAZOACRIDINE; SORAFENIB; TEMSIROLIMUS; TOPOTECAN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

ARTHRALGIA; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RESEARCH; CANCER SURVIVAL; CLEAR CELL CARCINOMA; CLINICAL STUDY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DIARRHEA; DRUG EFFICACY; DRUG HYPERSENSITIVITY; HAND FOOT SYNDROME; HUMAN; MAINTENANCE THERAPY; MONOTHERAPY; MUCINOUS CARCINOMA; MULTIPLE CYCLE TREATMENT; NEUROTOXICITY; OUTCOME ASSESSMENT; OVARY CANCER; PERIPHERAL NEUROPATHY; QUALITY OF LIFE; REVIEW; SURVIVAL TIME;

ADENOCARCINOMA, CLEAR CELL; ADENOCARCINOMA, MUCINOUS; ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CHEMOTHERAPY, ADJUVANT; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FEMALE; HUMANS; INFUSIONS, PARENTERAL; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; PACLITAXEL; POLYETHYLENE GLYCOLS;

EID: 53549122996     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.13.3.523     Document Type: Review

References (60)

1. Omura GA, Bundy BN, Berek JS, et al. Randomized trial of cyclophosphamide plus cisplatin with or without doxorubicin in ovarian carcinoma: Gynecologic Oncology Group Study. J Clin Oncol 1989;7:457-65
2. The Ovarian Cancer Meta-analysis Project. Cyclophosphamide plus cisplatin versus cyclophosphamide, doxorubicin, and cisplatin chemotherapy of ovarian carcinoma: a meta-analysis. J Clin Oncol 1991;9:1668-74
3. Swenerton K, Jeffrey J, Stuart G, et al. Cisplatin-cyclophosphamide versus carboplatin-cyclophosphamide in advanced ovarian cancer: a randomized Phase III study of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1992;10:718-26
4. Alberts DS, Green S, Hannigan EV, et al. Improved therapeutic index of carboplatin plus cuclophosphamide versus cisplatin plus cyclophosphamide: final report by the Southwest Oncology Group of a Phase III randomized trial in stages III and IV ovarian cancer. J Clin Oncol 1992;10:706-17
5. ICON2: a randomized trial of single-agent carboplatin against three-drug combination of CAP (cyclophosphamide, doxorubicin, and cisplatin) in women with ovarian cancer. ICON Collaborators. International Collaborative Ovarian Neoplasm Study. Lancet 1998;352:1571-6
6. McGuire WP, Hoskins WJ, Brady MF, et al, Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med 1996;334:1-6
7. Piccart MJ, Bertelsen K, James K, et al. Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results. J Natl Cancer Inst 2000;92:699-708
8. Ozols RF, Bundy BN, Greer BE, et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 2003;21:3194-200
9. Du Bois A, Luck HJ, Meier W, et al. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 2003;95:1320-9
10. Vasey PA, Jayson GC, Gordon A, et al. Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma. J Natl Cancer Inst 2004;96:1682-91
11. Du Bois A, Weber B, Rochon J, et al. Addition of epirubicin as a third drug to cathoplatin- paclitaxel in first-line treatment of advanced ovarian cancer: a prospectively randomized Gynecologic Cancer Intergroup trial by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group and the Groupe d'Investigateurs Nationaux pour I'Etude des Cancers Ovariens. J Clin Oncol 2006;24:1127-35
12. Bookman MA. GOG182-ICON5: 5-arm Phase III randomized trial of paclitaxel (P) and carboplatin (C) vs combinations with gemcitabine (G), PEG-liposomal doxorubicin (D), or topotecan (T) in patients (pts) with advanced-stage epithelial ovarian (EOC) or primary peritoneal (PPC) carcinoma. Proc Am Soc Clin Oncol 2006;24:256s
13. Piccart MJ, Floquet A, Scarfone G, et al. Intraperitoneal cisplatin versus no further treatment: 8-year results of EORTC 55875, a randomized Phase III study in ovarian cancer patients with a pathologically complete remission after platinum-based intravenous chemotherapy. Int J Gynecol Cancer 2003;13(Suppl 2):196-203
14. Pfisterer J, Weber B, Reuss A, et al. Randomized Phase III trial of topotecan following carboplatin and paclitaxel in first-line treatment of advanced ovarian cancer: a Gynecologic Cancer Intergroup trial of the AGO-OVAR and GINECO. J Natl Cancer Inst 2006;98:1036-45
15. De Placido S, Scambia G, Di Vagno G, et al. Topotecan compared with no therapy after response to surgery and carboplatin/paclitaxel in patients with ovarian cancer: Multicenter Italian Trials in Ovarian Cancer (MITO-1) randomized study. J Clin Oncol 2004;22:2635-42
16. Markman M, Liu PY, Wilczynski S, et al. Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: A Southwest Oncology Group and Gynecologic Oncology Group trial. J Clin Oncol 2003;21:2460-5
17. Conte PF, Favalli G, Gadducci A, et al. Final results of After-6 protocol 1: A Phase III trial of observation versus 6 courses of paclitaxel (Pac) in advanced ovarian cancer patients in complete response (CR) after platinum-paclitaxel chemotherapy (CT). Proc Am Soc Clin Oncol 2007;25:275a
18. Alberts DS, Liu PY, Hannigan EV, et al. Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer. N Engl J Med 1996;335:1950-5
19. Gadducci A, Carnini F, Chiara S, et al. Intraperitoneal versus intravenous cisplatin in combination with intravenous cyclophosphamide and epidoxorubicin in optimally cytoreduced advanced epithelial ovarian caner: a randomized trial of the Gruppo Oncologica Nord-Ovest. Gynecol Oncol 2000;76:157-62
20. Markman M, Bundy BN, Alberts DS, et al. Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume stage III ovarian carcinoma: an intergroup study of the Gynecologic Oncology Group, Southwestern Oncology Group, and Eastern Cooperative Oncology Group. J Clin Oncol 2001;19:1001-7
21. Yen M-S, Juang C-M, Lai C-R, et al. Intraperitoneal cisplatin-based chemotherapy vs intravenous cisplatin-based chemotherapy for stage III optimally cytoreduced epithelial ovarian cancer. Int J Gynecol Obstet 2001;72:55-60
22. Armstrong DK, Bundy B, Wenzel L, et al. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med 2006;354:34-43
23. Blackledge G, Lawton F, Redman C, et al. Response of patients in Phase II studies of chemotherapy in ovarian cancer: Implications for patients treatment and the design of Phase II trilas. Br J Cancer 1989;59:650-3
24. Markman M, Reichman B, Hakes T, et al. Response to second-line cisplatin-based intraperitoneal therapy in ovarian cancer: Influence of a prior response to intravenous cisplatin. J Clin Oncol 1991;9:1801-5
25. The ICON and AGO Collaborators. Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: ICON4/AGO-OVAR2.2 trial. Lancet 2003;361:2099-106
26. Pfisterer J, Vergote I, du Bois A, et al. Combination therapy with gemcitabine and carboplatin in recurrent ovarian cancer. Int J Gynecol Cancer 2005; 15 (Suppl. 1):36-41
27. Isonishi S, Yasuda M, Takahashi F, et al. Randomized Phase III trial of conventional paclitaxel and carboplatin (c-TC) versus dose dense weekly paclitaxel and carboplatin (dd-TC) in women with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: Japanese Gynecologic Oncology. Proc Am Soc Clin Oncol 2008;26:294s
28. Monk BJ, Choi DC, Pugmire G, et al. Activity of bevacizumab (rhuMAB VEGF) in advanced refractory epithelial ovarian caner. Gynecol Oncol 2005;96:902-5
29. Carcia AA, Oza AM, Hirte H, et al. Interim report of a Phase II clinical trial of bevacizumab (Bey) and low dose metronomic oral cyclophosphamide (mCTX) in recurrent ovarian (OC) and primary peritoneal carcinoma: a California Cancer Consortium Trial. J Clin Oncol 2005;23:455s
30. Cannistra SA, Matulonis UA, Penson RT, et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol 2007;25:5180-6
31. Burger RA, Sill MW, Monk BJ, et al. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J Clin Oncol 2007;25:5165-71
32. Wright JD, Hagemann A, Rader JS, et al. Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: a retrospective analysis. Cancer 2006;107:83-9
33. Cohn DE, Valmadre S, Resnick KE, et al. Bevacizumab and weekly taxane chemotherapy demonstrate activity in refractory ovarian cancer. Gynecol Oncol 2006;102:134-9
34. Sugiyama T, Fujiwara K. Clear cell carcinoma of the ovary. ASCO educational book (43rd Annual Meeting). 2007;313-26
35. Sugiyama T, Kamura T, Kigawa J, et al. Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer 2000;88:2584-9
36. Enomoto T, Kuragaki C, Yamasaki M, et al. Is clear cell carcinoma and mucinous carcinoma of the ovary sensitive to combination chemotherapy with paclitaxel and carboplatin? Proc Am Soc Clin Oncol 2003;22:447
37. Takano M, Sugiyama T, Yaegashi N, et al. Progression-free survival and overall survival of patients with clear cell carcinoma of the ovary treated with paclitaxel-carboplatin or irinotecan-cisplatin: retrospective analysis. Int J Clin Oncol 2007;12:256-60
38. Takano M, Sugiyama T, Tanaka T, et al. Comparison of irinotecan and cisplatin (CPT-P) versus paclitaxel and carboplatin (TC), as first-line chemotherapy for clear cell carcinoma (CCC): Japanese Gynecologic Oncology Group Study. Proceedings of the European Society of Gynecologic Oncology (Berlin) 29 October, 2007
39. Takano M, Kikuchi Y, Yaegashi N, et al. Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer 2006;94:1369-71
40. Itamochi H, Kigawa J, Sultana H, et al. Sensitivity to anticancer agents and resistance mechanisms in clear cell carcinoma of the ovary. Jpn J Cancer Res 2002;93:723-8
41. Itamochi H, Kigawa J, Sugiyama T, et al. Low proliferation activity may be associated with chemoresistance in clear cell carcinoma of the ovary. Obstet Gynecol 2002;100:281-7 contributed to low sensitivity to anticancer drugs.
42. Japanese Gynecologic Oncology Group (JGOG). Available from: http://jgog.gr.jp
43. Izzedine H, Billemont B, Thibault F, et al. New challenges in kidney cancer therapy: sunitinib. Ann Oncol 2007;18(Suppl 9):83-6
44. Buckstein R, Meyer RM, Seymour L, et al. Phase II testing of sunitinib: the National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182-185. Curr Oncol 2007;14:154-61
45. Kohne CH, Wils J, Lorenz M, et al. Randomized Phase III study of high-dose fluorouracil given as a weekly 24-hour infusion with or without leucovorin versus bolus fluorouracil plus leucovorin in advanced colorectal cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952. J Clin Oncol 2003;21:3721-8
46. Salts LB, John V. Blanke CC, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 2000;343:905-14
47. Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomized trial. Lancet 2000;355:1041-7
48. Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluoroutacil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004;22:23-30
49. de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced culorectal cancer. J Clin Oncol 2000;18:2938-47
50. Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004;22:229-37
51. Hoff PM, Ansari R, Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized Phase III study: J Clin Oncol 2001;15:2282-92
52. Twelves C, Boyer M, Findlay M, et al. Capecitabine (Xeloda™) improves medical resource use compared with 5-fluorouracil plus leucovorin in a Phase III trial conducted in patients with advanced colorectal carcinoma. Eur J Cancer 2001;37:597-604
53. Cassidy J, Clarke S, Rubio ED, et al. First efficacy and safety results from XELOX-1/NO16966, a randomised 2×2 factorial Phase III trial of XELOX vs. FOLFOX4 + bevacizumab or placebo in first-line metastatic colorectal cancer (MCRC). Ann Oncol 2006;17:LBA3
54. Rothenberg ML, Navarro M, Butts C, et al. Phase III trial of capecitabine + oxaliplatin (XELOX) vs. 5-fluorouracil (5-FU), leucovorin (LV), and oxaliplatin (FOLFOX4) as 2nd-line treatment for patients with metastatic colorectal cancer (MCRC). J Clin Oncol 2007;25:18S
55. Ajani JA, Lee FC, Singh DA, Haller DG, et al. Multicenter Phase II trial of S-1 plus cisplatin in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma. J Clin Oncol 2006;24:663-7
56. Inokuchi M, Yamashita T, Yamada H, et al. Phase I/II study of S-1 combined with irinotecan for metastatic advanced gastric cancer. Br J Cancer 2006;94:1130-5
57. Yushida K, Ninomiya M, Takakura N, et al. Phase II study of docetaxel and S-1 combination therapy for advanced or recurrent gastric cancer. Clin Cancer Res 2006;12:3402-7
58. Mochiki E, Ohn T, Kamiyama Y, et al. Phase I/II study of S-1 combined with paclitaxel in patients with unresectable and/or recurrent advanced gastric cancer. Br J Cancer 2006;95:1642-7
59. Cima Science, Available from: http://www.cimanet.jp/ver4/u/index.php
60. Available from: http://www.cancer.gov/highlights/clin_annc_010506.pdf