Kinetics and mechanism of the hydrolytic degradation of Indinavir: Intramolecular catalysis

Journal of Pharmaceutical Sciences

Volumn 97, Issue 9, 2008, Pages 3810-3819

  Toteva, Maria M ^a   Zanon, Roger ^a   Ostovic, Drazen ^a  

^a AMGEN INC   (United States)

Author keywords

Acid base catalysis; Amide hydrolysis; Buffer catalysis; Chemical stability; Indinavir; Intramolecular catalysis; Kinetics; Lactonization; Mechanism of degradation; pH rate profile

Indexed keywords

INDINAVIR;

ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG DEGRADATION; DRUG MECHANISM; HYDROLYSIS; LACTONIZATION; PH MEASUREMENT;

EID: 53549122454     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21259     Document Type: Article

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