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3242696730
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Physiological and pathological actions of sphingosine 1-phosphate
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Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol 2004; 15:513-520.
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(2004)
Semin Cell Dev Biol
, vol.15
, pp. 513-520
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Hla, T.1
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2
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46949104885
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Takabe K, Paugh SW, Milstien S, Spiegel S. 'Inside-Out' signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 2008; 60:181-195. A recent and comprehensive review of S1P and S1PR activity and regulation, including detailed discussion of preclinical and clinical trials of therapies targeting S1P signalling.
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Takabe K, Paugh SW, Milstien S, Spiegel S. 'Inside-Out' signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 2008; 60:181-195. A recent and comprehensive review of S1P and S1PR activity and regulation, including detailed discussion of preclinical and clinical trials of therapies targeting S1P signalling.
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38549152194
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Hannun YA, Obeid LM. Principles of bioactrve lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008; 9:139-150. This excellent review provides a broader perspective of S1P signalling in the overall context of other sphingolipid-derived signalling molecules.
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Hannun YA, Obeid LM. Principles of bioactrve lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008; 9:139-150. This excellent review provides a broader perspective of S1P signalling in the overall context of other sphingolipid-derived signalling molecules.
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5
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33947634013
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Hanel P, Andreani P, Grater MH. Erythrocytes store and release sphingosine 1-phosphate in Wood. Faseb J 2007; 21:1202-1209. This study demonstrates the capacity of human RBC to take up, store and release SIP. The authors suggest that erythrocytes represent a stable store of plasma S1P. Release of S1P from RBC was not dependent on S1P synthesis, suggesting that the cells may acquire the lipid from other tissue sources.
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Hanel P, Andreani P, Grater MH. Erythrocytes store and release sphingosine 1-phosphate in Wood. Faseb J 2007; 21:1202-1209. This study demonstrates the capacity of human RBC to take up, store and release SIP. The authors suggest that erythrocytes represent a stable store of plasma S1P. Release of S1P from RBC was not dependent on S1P synthesis, suggesting that the cells may acquire the lipid from other tissue sources.
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6
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34247379074
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Pappu R, Schwab SR, Comelissen I, et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 2007; 316:295-298. This is one of two recent papers that explore the cellular sources of plasma and lymph S1P. The authors conclude that RBC contributes most plasma S1P but that lymph S1P derives from a nonhaematopoietic source. Using mice in which the kinases that generate S1P were conditionally ablated, it was shown that restoration of S1P to plasma (by bone-marrow transplantation) rescued lymphocyte trafficking to blood but not lymph.
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Pappu R, Schwab SR, Comelissen I, et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 2007; 316:295-298. This is one of two recent papers that explore the cellular sources of plasma and lymph S1P. The authors conclude that RBC contributes most plasma S1P but that lymph S1P derives from a nonhaematopoietic source. Using mice in which the kinases that generate S1P were conditionally ablated, it was shown that restoration of S1P to plasma (by bone-marrow transplantation) rescued lymphocyte trafficking to blood but not lymph.
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7
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41449112571
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Venlrataraman K, Lee YM, Michaud J, et al. Vascular erdothelium as a contributor of plasma sphingosine 1-phosphate. Ore Res 2008; 102:669-676. Similar to the above work by Pappu, in this study the authors use irradiation and bone marrow transfers in WT and SphK-deficient mice to explore the contribution of haematopoietic cells to plasma S1P. Rather surprisingly they observed no effect of total body irradiation on the plasma concentration of S1P in WT mice, nor of selection ablation of RBC. They provide some evidence that vascular endothelial cells may contribute a significant proportion of the plasma S1P pool.
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Venlrataraman K, Lee YM, Michaud J, et al. Vascular erdothelium as a contributor of plasma sphingosine 1-phosphate. Ore Res 2008; 102:669-676. Similar to the above work by Pappu, in this study the authors use irradiation and bone marrow transfers in WT and SphK-deficient mice to explore the contribution of haematopoietic cells to plasma S1P. Rather surprisingly they observed no effect of total body irradiation on the plasma concentration of S1P in WT mice, nor of selection ablation of RBC. They provide some evidence that vascular endothelial cells may contribute a significant proportion of the plasma S1P pool.
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