The prognostic value of nestin expression in newly diagnosed glioblastoma: Report from the Radiation Therapy Oncology Group

Radiation Oncology

Volumn 3, Issue 1, 2008, Pages

  Chinnaiyan, Prakash ^a   Wang, Meihua ^b   Rojiani, Amyn M ^a   Tofilon, Philip J ^a   Chakravarti, Arnab ^c   Ang, K Kian ^d   Zhang, Hua Zhong ^d   Hammond, Elizabeth ^e   Curran Jr , Walter ^f   Mehta, Minesh P ^g  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b AMERICAN COLLEGE OF RADIOLOGY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e LDS HOSPITAL   (United States)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g University of Wisconsin Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; DACARBAZINE; DRUG DERIVATIVE; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; NESTIN; TEMOZOLOMIDE;

ARTICLE; BIOSYNTHESIS; BRAIN TUMOR; CELL LINEAGE; DISEASE FREE SURVIVAL; GENE EXPRESSION REGULATION; GLIOBLASTOMA; HUMAN; METABOLISM; METHODOLOGY; MULTIMODALITY CANCER THERAPY; NERVE CELL; PHENOTYPE; PROGNOSIS; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; CELL LINEAGE; COMBINED MODALITY THERAPY; DACARBAZINE; DISEASE-FREE SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; INTERMEDIATE FILAMENT PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PHENOTYPE; PROGNOSIS; RESEARCH DESIGN; TREATMENT OUTCOME;

EID: 53549099123     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-3-32     Document Type: Article

References (26)

1. Hockfield S McKay RD Identification of major cell classes in the developing mammalian nervous system J Neurosci 1985, 5(12):3310-3328 4078630
2. Lendahl U Zimmerman LB McKay RD CNS stem cells express a new class of intermediate filament protein Cell 1990, 60(4):585-595 10.1016/ 0092-8674(90)90662-X 1689217
3. Holland EC Progenitor cells and glioma formation Curr Opin Neurol 2001, 14(6):683-688 10.1097/00019052-200112000-00002 11723374
4. Wiese C Rolletschek A Kania G Blyszczuk P Tarasov KV Tarasova Y Wersto RP Boheler KR Wobus AM Nestin expression-a property of multi-lineage progenitor cells? Cell Mol Life Sci 2004, 61(19-20):2510-2522 10.1007/ s00018-004-4144-6 15526158
5. Singh SK Hawkins C Clarke ID Squire JA Bayani J Hide T Henkelman RM Cusimano MD Dirks PB Identification of human brain tumour initiating cells Nature 2004, 432(7015):396-401 10.1038/nature03128 15549107
6. Bao S Wu Q McLendon RE Hao Y Shi Q Hjelmeland AB Dewhirst MW Bigner DD Rich JN Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature 2006, 444(7120):756-760 10.1038/nature05236 17051156
7. Chou YH Khuon S Herrmann H Goldman RD Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis Mol Biol Cell 2003, 14(4):1468-1478 153115 12686602 10.1091/mbc.E02-08-0545
8. Sahlgren CM Mikhailov A Hellman J Chou YH Lendahl U Goldman RD Eriksson JE Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase J Biol Chem 2001, 276(19):16456-16463 10.1074/jbc.M009669200 11278541
9. Sahlgren CM Pallari HM He T Chou YH Goldman RD Eriksson JE A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death Embo J 2006, 25(20):4808-4819 1618100 17036052 10.1038/sj.emboj.7601366
10. Thomas SK Messam CA Spengler BA Biedler JL Ross RA Nestin is a potential mediator of malignancy in human neuroblastoma cells J Biol Chem 2004, 279(27):27994-27999 10.1074/jbc.M312663200 15117961
11. Dahlstrand J Collins VP Lendahl U Expression of the class VI intermediate filament nestin in human central nervous system tumors Cancer Res 1992, 52(19):5334-5341 1382841
12. Tohyama T Lee VM Rorke LB Marvin M McKay RD Trojanowski JQ Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells Lab Invest 1992, 66(3):303-313 1538585
13. Ma YH Mentlein R Knerlich F Kruse ML Mehdorn HM Held-Feindt J Expression of stem cell markers in human astrocytomas of different WHO grades J Neurooncol 2008, 86(1):31-45 10.1007/s11060-007-9439-7 17611714
14. Maderna E Salmaggi A Calatozzolo C Limido L Pollo B Nestin, PDGFRbeta, CXCL12 and VEGF in Glioma Patients: Different Profiles of (Pro-Angiogenic) Molecule Expression Are Related with Tumor Grade and May Provide Prognostic Information Cancer Biol Ther 2007, 6:(7) 17611402
15. Mao Y Zhou L Zhu W Wang X Yang G Xie L Mao X Jin K Proliferative status of tumor stem cells may be correlated with malignancy grade of human astrocytomas Front Biosci 2007, 12:2252-2259 10.2741/2227 17127461
16. Schiffer D Manazza A Tamagno I Nestin expression in neuroepithelial tumors Neurosci Lett 2006, 400(1-2):80-85 10.1016/j.neulet.2006.02.034 16529857
17. Strojnik T Rosland GV Sakariassen PO Kavalar R Lah T Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: Correlation of nestin with prognosis of patient survival Surg Neurol 2007, 68(2):133-143 discussion 143-134. 10.1016/ j.surneu.2006.10.050 17537489
18. Chakravarti A Seiferheld W Tu X Wang H Zhang HZ Ang KK Hammond E Curran W Jr Mehta M Immunohistochemically determined total epidermal growth factor receptor levels not of prognostic value in newly diagnosed glioblastoma multiforme: Report from the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 2005, 62(2):318-327 15890570
19. Yang X Wu Q Yu X Xu C Ma B Zhang X Li S Lahn B Xiang AP Nestin expression in different tumors and its relevance to malignant grade J Clin Pathol 2008, 61(4):467-473 10.1136/jcp.2007.047605 17873113
20. Sugawara K Kurihara H Negishi M Saito N Nakazato Y Sasaki T Takeuchi T Nestin as a marker for proliferative endothelium in gliomas Lab Invest 2002, 82(3):345-351 11896213
21. Brychtova S Fiuraskova M Hlobilkova A Brychta T Hirnak J Nestin expression in cutaneous melanomas and melanocytic nevi J Cutan Pathol 2007, 34(5):370-375 10.1111/j.1600-0560.2006.00627.x 17448190
22. Klein WM Wu BP Zhao S Wu H Klein-Szanto AJ Tahan SR Increased expression of stem cell markers in malignant melanoma Mod Pathol 2007, 20(1):102-107 10.1038/modpathol.3800720 17143262
23. Li H Cherukuri P Li N Cowling V Spinella M Cole M Godwin AK Wells W DiRenzo J Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors Cancer Res 2007, 67(2):501-510 10.1158/0008-5472.CAN-05-4571 17234757
24. Ehrmann J Kolar Z Mokry J Nestin as a diagnostic and prognostic marker: immunohistochemical analysis of its expression in different tumours J Clin Pathol 2005, 58(2):222-223 1770570 15677549 10.1136/jcp.2004.021238
25. Mirimanoff R Mason W Bent Van den M Kortmann R Taphoorn M Brandes A Villa S Cairncross G Gorlia T Stupp R Is Long-Term Survival in Glioblastoma Possible? Updated Results of the EORTC/NCIC Phase III randomized Trial on Radiotherapy (RT) and Concomitant and Adjuvant Temozolomide (TMZ) vesus RT Alone Int J Radiat Oncol Biol Phys 2007, 69(3):S1
26. Stupp R Mason WP Bent van den MJ Weller M Fisher B Taphoorn MJ Belanger K Brandes AA Marosi C Bogdahn U Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma N Engl J Med 2005, 352(10):987-996 10.1056/NEJMoa043330 15758009