Discovery of a stable molecular complex of an API with HCL: A long journey to a conventional salt

Journal of Pharmaceutical Sciences

Volumn 97, Issue 9, 2008, Pages 3721-3726

  Peresypkin, Andrey ^a,b   Variankaval, Narayan ^a,c   Ferlita, Russell ^a   Wenslow, Robert ^a   Smitrovich, Jacqueline ^a   Thompson, Karen ^a   Murry, Jerry ^a   Crocker, Louis ^a   Mathre, David ^a   Wang, Jian ^a   Harmon, Paul ^a   Ellison, Martha ^a   Song, Sherry ^a   Makarov, Alexey ^a   Helmy, Roy ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

^c Chemical Engineering R and D ^*  (United States)

Author keywords

Cocrystal; HCl cocrystal; HCl complex; Salts

Indexed keywords

AMIDE; BENZYL THIOCYANATE; NITROGEN; SODIUM CHLORIDE;

ARTICLE; ATOM; COMPLEX FORMATION; CRYSTAL; CRYSTALLIZATION; ENVIRONMENTAL TEMPERATURE; HEATING; HUMIDITY; INFRARED SPECTROSCOPY; METHODOLOGY; MONTE CARLO METHOD; PHYSICAL CHEMISTRY; POWDER DIFFRACTION; SIMULATION; SOLID STATE;

EID: 53549097633     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21264     Document Type: Article

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14. All experiments on the bis-HCl salt described in this manuscript were performed on Form I which is referred to as bis-HCl salt. Please refer to Supporting Information for additional characterization details.