Practical implications of liver and heart iron load assessment by T2*-MRI in children and adults with transfusion-dependent anemias

American Journal of Hematology

Volumn 83, Issue 10, 2008, Pages 781-783

  Chirnomas, Sarah Deborah ^a,b   Geukes Foppen, Marnix ^a   Barry, Kristen ^a   Braunstein, Jennifer ^a   Kalish, Leslie A ^a   Neufeld, Ellis J ^a,b   Powell, Andrew J ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ANEMIA; ARTICLE; BLOOD TRANSFUSION; BODY BURDEN; CHELATION THERAPY; CHILD; CORRELATION ANALYSIS; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; IRON BURDEN; IRON HEART LEVEL; IRON LIVER LEVEL; LIVER HEMOSIDEROSIS; LIVER LEVEL; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAMETER; PATIENT MONITORING; PRIORITY JOURNAL; THALASSEMIA; THALASSEMIA INTERMEDIA; TISSUE LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA; BLOOD TRANSFUSION; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DATABASES, FACTUAL; FEMALE; HEART; HUMANS; IRON; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; MYOCARDIUM; RETROSPECTIVE STUDIES; THALASSEMIA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 53549096526     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21221     Document Type: Article

References (14)

1. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997;89:739-761.
2. Anderson LJ, Holden S, Davis B, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001;22:2171-2179.
3. Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2 * mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005;106:1460-1465.
4. Westwood MA, Sheppard MN, Awogbade M, et al. Myocardial biopsy and T2 * magnetic resonance in heart failure due to thalassaemia. Br J Haematol 2005;128:2.
5. Wood JC, Otto-Duessel M, Aguilar M, et al. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation 2005;112:535-543.
6. Ghugre NR, Enriquez CM, Gonzalez I, et al. MRI detects myocardial iron in the human heart. Magn Reson Med 2006;56:681-686.
7. Mavrogeni SI, Markussis V, Kaklamanis L, et al. A comparison of magnetic resonance imaging and cardiac biopsy in the evaluation of heart iron overload in patients with β-thalassemia major. Eur J Haematol 2005;75:241-247.
8. Wood JC, Tyszka JM, Carson S, et al. Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood 2004;103:1934-1936.
9. Anderson LJ, Westwood MA, Holden S, et al. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: A prospective study using T2* cardiovascular magnetic resonance. Br J Haematol 2004;127:348-355.
10. Westwood MA, Shah F, Anderson LJ, et al. Myocardial tissue characterization and the role of chronic anemia in sickle cell cardiomyopathy. J Magn Reson Imaging 2007;26:564-568.
11. Vichinsky E, Butensky E, Fung E, et al. Comparison of organ dysfunction in transfused patients with SCD or β-thalassemia. Am J Hematol 2005,80:70-74.
12. Westwood MA, Firmin DN, Gildo M, et al. Intercentre reproducibility of magnetic resonance T2* measurements of myocardial iron in thalassaemia. Int J Cardiovasc Imaging 2005;21:531-538.
13. Westwood M, Anderson LJ, Firmin DN, et al. A single breath-hold multiecho T2* cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload. J Magn Reson Imaging 2003;18:33-39.
14. Westwood MA, Anderson LJ, Firmin DN, et al. Interscanner reproducibility of cardiovascular magnetic resonance T2* measurements of tissue iron in thalassemia. J Magn Reson Imaging 2003;18:616-620.