Saline versus balanced hydroxy ethyl starch: Does it matter?

Current Opinion in Anaesthesiology

Volumn 21, Issue 5, 2008, Pages 679-683

  Boldt, Joachim ^a  

^a KLINIKUM LUDWIGSHAFEN   (Germany)

Author keywords

Acidosis; Balanced fluids; Hydroxyethylstarch; Hypovolemia; Volume replacement

Indexed keywords

BASE; GELATIN; HETASTARCH; HUMAN ALBUMIN; PLASMA SUBSTITUTE; RINGER LACTATE SOLUTION; SODIUM CHLORIDE; TETRASPAN; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ALLOPATHY; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CLINICAL TRIAL; DRUG MEGADOSE; FLUID THERAPY; GYNECOLOGIC SURGERY; HEMODILUTION; HEMOSTASIS; HUMAN; HYPERCHLOREMIC ACIDOSIS; HYPOVOLEMIA; INTENSIVE CARE UNIT; METABOLIC ACIDOSIS; MORTALITY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RESUSCITATION; REVIEW; SIDE EFFECT; THROMBOCYTE AGGREGATION; THROMBOELASTOGRAPHY; TISSUE PERFUSION;

ANIMALS; HETASTARCH; HUMANS; HYPOVOLEMIA; PLASMA SUBSTITUTES; SODIUM CHLORIDE;

EID: 53549085417     PISSN: 09527907     EISSN: None     Source Type: Journal    
DOI: 10.1097/ACO.0b013e32830dd05b     Document Type: Review

References (39)

1. Deane SA, Gaudry PL, Woods P, et al. The managment of injuries: a review of deaths in hospital. Aust NZJ Surg 1988; 58:463-469,
2. Vollmar B, Menger MD. Volume replacement and microhemodynamic changes in polytrauma. Langenbecks Arch Surg 2004; 389:485-491.
3. Cussak RJ, Ball JAS, Rhodes A, Grounds RM. Improving postoperative morbidity and mortality. Intensivmed 2002; 39:571-577.
4. Mythen MG, Hamilton MA. Hyperchloremic metabolic acidosis: is it clinically relevant? Transfus Altern Transfus Med 2001; 3:15-19.
5. Boldt J. The balanced concept of fluid resuscitation. Br J Anaesth 2007; 99:312-315.
6. McFarlane C, Lee A. A comparison of Plasmalyte 148 and 0.9% saline for intra-operative fluid replacement. Anaesthesia 1994; 49:779-781.
7. Kellum JA. Saline-induced hyperchloremic metabolic acidosis. Crit Care Med 2002; 30:259-261.
8. Wilkes NJ, Woolf R, Mutch M, et al. The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 2001 ; 93:811-816.
9. Lang K, Boldt J, Suttner S, Haisch G. Colloids versus crystalloids and tissue oxygen tension in patients undergoing major abdominal surgery. Anesth Analg 2001 ; 93:405-409.
10. Boldt J. Do plasma substitutes have additional properties beyond correcting volume deficits? Shock 2006; 25:103-116.
11. Rehm M, Orth V, Scheingraber S, et al. Acid-base changes caused by 5% albumin versus 6% hydroxyethyl starch solution in patients undergoing acute normovolemic hemodilution: a randomized prospective study. Anesthesiology 2000; 93:1174-1183.
12. Smith I, Kumar P, Molloy S, et al. Base excess and lactate as prognostic indicators for patients admitted to intensive care. Intensive Care Med 2001 ; 27:74-83.
13. Hugot P, Sicsic JC, Schaffuser A, et al. Base deficit in immediate postoperative period of coronary surgery with cardiopulmonary bypass and length of stay in intensive care unit. Intensive Care Med 2003; 29:257-261.
14. Prough DS, Bidani A. Hyperchloremic metabolic acidosis is a predictable consequence of intraoperative infusion of 0.9% saline. Anesthesiology 1999; 90:1247-1249.
15. Scheingraber S, Rehm M, Finsterer U. Rapid saline infusion produces hyperchloremic acidosis in patient gynecologic surgery. Anesthesiology 1999; 90: 1265-1270.
16. Healey MA, Davis RE, Liu FC, et al. Lactated Ringer's is superior to normal saline in a model of massive hemorrhage and resuscitation. J Trauma 1998; 45:894-899.
17. Wilcox CS. Regulation of renal blood flow by plasma chloride. J Clin Invest 1983; 71:726-735.
18. Kiraly LN, Differding JA, Enomoto TM, et al. Resuscitation with normal saline (NS) vs. lactated ringers (LR) modulates hypercoagulability and leads to increased blood loss in an uncontrolled hemorrhagic shock swine model. J Trauma 2006; 61:57-64.
19. Williams EL, Hildebrand KL, McCormick SA, Bedel MJ. The effect of intravenous lactated Ringer's solution versus 0.9% sodium chloride solution on serum osmolarity in human volunters. Anesth Analg 1999; 88:999-1003.
20. Waters JH, Gottlieb A, Schoenwald P, et al. Normal saline versus Ringer's lactate solutions for intraoperative fluid management in patients undergoing abdominal aortic aneurysm repair: an outcome study. Anesth Analg 2001 ; 93:817-822.
21. Gan TJ, Bennett-Guerrero E, Phillips-Bute B, et al. Hextend, a physiologically balanced plasma expander for large volume use in major surgery: a randomized phase III clinical trial. Anesth Analg 1999; 88:992-998.
22. Wilkes NJ, Woolf RL, Powanda MC, et al. Hydroxyethyl starch in balanced electrolyt solution (Hextend): pharmacokinetic and pharmacodynamic profiles in healthy volunteers. Anesth Analg 2002; 94:538-544.
23. Kozek-Langenecker SA. Effects of hydroxyethyl starch solutions on hemostasis. Anesthesiology 2005; 103:654-660.
24. deJonge E, Levi M. Effects of different plasma substitutes on blood coagulation: a comparative review. Crit Care Med 2001; 29:1261-1267.
25. Franz A, Bräunlich P, Gamsjäger T, et al. The effects of hydroxyethyl starches of varying molecular weights on platelet function. Anesth Analg 2001; 92: 1402-1407.
26. Sander O, Reinhart K, Meier-Hellmann A. Eqivalence of hydroxyethyl starch HES 130/0.4 and HES 200/0.5 for postoperative volume replacement in major gynaecological surgery. Acta Anaesthesiol Scand 2003; 47:1151-1158.
27. Boldt J, Schöllhorn T, Schulte G, Pabsdorf M. Volume replacement with a new balanced hydroxyethylstarch preparation (HES 130/0.42) in patients undergoing major abdominal surgery. EJA 2006; 23:1-9.
28. Base E, Standi T, Mahl C, Jungheinrich C. Comparison of 6% HES 130/0.4 in a balanced electrolyte solution versus 6% HES 130/0.4 in saline solution in cardiac surgery. Crit Care 2006; 10 (Suppl 1 ):176.
29. Warren BB, Durieux ME. Hydroxyethylstarch: safe or not? Anesth Analg 1997; 84:206-212.
30. Roche AM, James MF, Grocott MP, Mythen MG. Coagulation effects of in vitro serial haemodilution with a balanced electrolyte hetastarch solution compared with a saline-based hetastarch solution and lactated Ringer's solution. Anaesthesia 2002; 57:950-955.
31. Roche AM, James MF, Bennett-Guerrero E, Mythen MG. A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids. Anesth Analg 2006; 102:1274-1279.
32. Bick RL. Evaluation of a new hydroxyethyl starch preparation (Hextend) on selected coagulation parameters. Clin Appl Thrombosis/Hemostasis 1995; 1:215-229.
33. Blaicher AM, Reiter WJ, Blaicher W, et al. The effect of hydroxyethyl starch on platelet aggregation in vitro. Anesth Analg 1998; 86:1318-1321.
34. Stögermüller B, Stark J, Willschke H, et al. The effect of hydroxyethylstarch 200kD on platelet function. Anesth Analg 2000; 91:823-827.
35. Martin G, Bennett-Guerrero E, Wakeling H, et al. A prospective, randomized comparison of thromboelastographic coagulation profile in patients receiving lactated Ringer's solution, 6% hetastarch in a balanced-saline vehicle, or 6% hetastarch in saline during major surgery. J Cardiothorac Vasc Anesth 2002; 16:441-446.
36. Boldt J, Mengistu A, Wolf M. A new plasma-adapted hydroxyethylstarch (HES) reparation - in vitro coagulation studies using thrombelastography and whole blood aggregometry. Anesth Analg 2007; 104:425-430.
37. Boldt J, Mengistu A, Seyfert UT, et al. The impact of a medium molecular weight, low molar substitution hydroxyethyl starch dissolved in a physiologically balanced electrolyte solution on blood coagulation and platelet function in vitro. Vox Sang 2007; 93:139-144.
38. Kellum JA. Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with saline. Crit Care Med 2002; 30:300-530.
39. Webb AR. Crystalloid or colloid for resuscitation. Are we any the wiser? Crit Care 1999; 3:R25-R28.