Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: Methylglyoxal attenuates protein synthesis through phosphorylation of eIF2α

Biochemical and Biophysical Research Communications

Volumn 376, Issue 4, 2008, Pages 738-742

  Nomura, Wataru ^a   Maeta, Kazuhiro ^a   Kita, Keiko ^a   Izawa, Shingo ^a   Inoue, Yoshiharu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Adaptation; eIF2 ; Gcn4; Methylglyoxal; S. cerevisiae; Stress; Translation initiation

Indexed keywords

CATALASE; INITIATION FACTOR 2ALPHA; METHYLGLYOXAL; TRANSCRIPTION FACTOR GCN4;

ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL STRESS; ENZYME ACTIVATION; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MALNUTRITION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; TRANSLATION INITIATION;

ADAPTATION, PHYSIOLOGICAL; CATALASE; DNA-BINDING PROTEINS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION, FUNGAL; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PYRUVALDEHYDE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 53449084103     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.09.063     Document Type: Article

References (25)

1. Inoue Y., and Kimura A. Methylglyoxal and regulation of its metabolism in microorganisms. Adv. Microbiol. Physiol. 37 (1995) 177-227
2. Shapiro R., Cohen B.I., Shiuey S.J., and Maurer H. On the reaction of guanine with glyoxal, pyruvaldehyde, and kethoxal, and the structure of the acylguanines. A new synthesis of N2-alkylguanines, Biochemistry 8 (1969) 238-245
3. Együd L.G., and Szent-Györgyi A. On the regulation of cell division. Proc. Natl. Acad. Sci. USA 56 (1966) 203-207
4. Kozarich J.W., and Deegan J.L. 7-Methylguanosine-dependent inhibition of globin mRNA translation by methylglyoxal. J. Biol. Chem. 254 (1979) 9345-9348
5. Lozano A.M., and Mezl V.A. Methylglyoxal inhibits the translation of natural and chemically decapped mRNAs. Biosci. Rep. 4 (1984) 783-788
6. Maeta K., Izawa S., Okazaki S., Kuge S., and Inoue Y. Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis. Mol. Cell. Biol. 24 (2004) 8753-8764
7. Maeta K., Izawa S., and Inoue Y. Methylglyoxal, a metabolite derived from glycolysis, functions as a signal initiator of the high osmolarity glycerol-mitogen-activated protein kinase cascade and calcineurin/Crz1-mediated pathway in Saccharomyces cerevisiae. J. Biol. Chem. 280 (2005) 253-280
8. Zuin A., Vivancos A.P., Sansó M., Takatsume Y., Ayté J., Inoue Y., and Hidalgo E. The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe. J. Biol. Chem. 280 (2005) 36708-36713
9. Takatsume Y., Izawa S., and Inoue Y. Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 281 (2006) 9086-9092
10. Hinnebusch A.G. Translational regulation of GCN4 and the general amino acid control of yeast. Annu. Rev. Microbiol. 59 (2005) 407-450
11. Inoue Y., Tsujimoto Y., and Kimura A. Expression of the glyoxalase I gene of Saccharomyces cerevisiae is regulated by high osmolarity glycerol mitogen-activated protein kinase pathway in osmotic stress response. J. Biol. Chem. 273 (1988) 2977-2983
12. Sakumoto N., Mukai Y., Uchida K., Kouchi T., Kuwajima J., Nakagawa Y., Sugioka S., Yamamoto E., Furuyama T., Mizubuchi H., Ohsugi N., Sakuno T., Kikuchi K., Matsuoka I., Ogawa N., Kaneko Y., and Harashim S. A series of protein phosphatase gene disruptants in Saccharomyces cerevisiae. Yeast 15 (1999) 1669-1679
13. Kubota H., Ota K., Sakaki Y., and Ito T. Budding yeast GCN1 binds the GI domain to activate the eIF2α kinase GCN2. J. Biol. Chem. 276 (2001) 17591-17596
14. Martinez-Pastor M.T., Marchler G., Schüller C., Marchler-Bauer A., Ruis H., and Estruch F. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). EMBO J. 15 (1996) 2227-2235
15. Merrick W.C., and Hershey J.W.B. The pathway and mechanism of eukaryotic protein synthesis. In: Hershey J.W.B., Matthews M.B., and Sonenberg N. (Eds). Translational Control (1996), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York 31-69
16. Wek S.A., Zhu S., and Wek R.C. The histidyl-tRNA synthetase-related sequence in the eIF-2α protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol. Cell. Biol. 15 (1995) 4497-4506
17. Vazquez de Aldana C.R., Marton M.J., and Hinnebusch A.G. GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2α kinase GCN2 in amino acid-starved cells. EMBO J. 14 (1995) 3184-3199
18. Natarajan K., Meye M.R., Jackso B.M., Slade D., Roberts C., Hinnebusch A.G., and Marton M.J. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol. Cell. Biol. 21 (2001) 4347-4368
19. Hinnebusch A.G., and Natarajan K. Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot. Cell 1 (2001) 22-32
20. Oliviero S., Robinson G.S., Struhl K., and Spiegelman B.M. Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation. Genes Dev. 6 (1992) 1799-1809
21. Oliviero S., and Struhl K. Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter. Proc. Natl. Acad. Sci. USA 88 (1991) 224-228
22. Struhl K. The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast. Nature 332 (1988) 649-650
23. Moye-Rowley W.S. Regulation of the transcriptional response to oxidative stress in fungi: similarities and differences. Eukaryot. Cell 2 (2003) 381-389
24. Maeta K., Mori K., Takatsume Y., Izawa S., and Inoue Y. Diagnosis of cell death induced by methylglyoxal, a metabolite derived from glycolysis, in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 243 (2005) 87-92
25. Inoue Y., and Kimura A. Identification of the structural gene for glyoxalase I from Saccharomyces cerevisiae. J. Biol. Chem. 271 (1996) 25958-25965