Long-term alpha interferon treatment is effective on anaemia and significantly reduces iron overload in congenital dyserythropoiesis type I

European Journal of Haematology

Volumn 73, Issue 5, 2004, Pages 380-383

  Lavabre Bertrand, Thierry ^a,c   Ramos, Jeanne ^b   Delfour, Christophe ^b   Henry, Laurent ^a   Guiraud, Isabelle ^a   Carillo, Serge ^a   Wagner, André ^b   Bureau, Jean Paul ^a   Blanc, Pierre ^b  

^a NÎMES UNIVERSITY HOSPITAL   (France)

^b MONTPELLIER UNIVERSITY HOSPITAL   (France)

^c Laboratoire d'Anatomie Experimentale   (France)

Author keywords

Congenital dyserythropoietic anaemia; Ferritin; Interferon; Iron overload

Indexed keywords

ALPHA INTERFERON; ALPHA2A INTERFERON; FERRITIN; HEMOGLOBIN; PEGINTERFERON; PEGINTERFERON ALPHA2B;

ANEMIA; ARTICLE; CASE REPORT; CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE 1; CORRELATION ANALYSIS; DRUG EFFICACY; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; HUMAN; HUMAN CELL; INFANT; IRON OVERLOAD; LIVER BIOPSY; LONG TERM CARE; LOW DRUG DOSE; PRESCHOOL CHILD; PRIORITY JOURNAL; SIDE EFFECT;

ADULT; ANEMIA, DYSERYTHROPOIETIC, CONGENITAL; BIOPSY; ERYTHROCYTES; FEMALE; FERRITINS; HEMOGLOBINS; HUMANS; INTERFERON-ALPHA; IRON OVERLOAD; LIVER; TIME FACTORS;

EID: 5344265331     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2004.00310.x     Document Type: Article

References (13)

1. LAVABRE-BERTRAND T, BLANC P, NAVARRO R, SAGHROUN M, VANNEREAU H, BRAUN M, TAÏB J, LAVABRE-BERTRAND C, NAVARRO M. Alpha Interferon therapy for congenital dyserythropoiesis type I. Brit J Haematol 1995;89:929-932.
2. VIRJEE S, HATTON C. Congenital dyserythropoiesis type I and alpha-interferon therapy. Brit J Haematol 1996;94:581-582.
3. WICKRAMASINGHE S. Response of CDA type I to alpha-interferon. Eur J Haematol 1997;58:121-123.
4. SHAMSEDDINE A, TAHER A, JAAFAR H, HAIDAR J, NASR R, ARZOUMIAN V, SALEM Z, BAZARBACHI A. Interferon alpha is an effective therapy for congenital dyserythropoietic anaemia type I. Eur J Hematol 2000;65:207-209.
5. PAREZ N, DOMMERGUES M, ZUPAN V, et al. Severe congenital dyserythropoietic anaemia type I: prenatal management, transfusion support and alpha-interferon therapy. Brit J Haematol 2000;110:420-423.
6. RODA L, PASCHE J, FOURNIER A, TEROROTUA V, WICKRAMASINGHE S, TAMARY H, SCHISCHMANOFF P, TCHERNIA G, DELAUNAY J. Congenital dyserythropoietic anemia, type 1, in a Polynesian patient: response to interferon alpha 2b. J Pediatr Oncol 2002;24:503-506.
7. BARLOW C, PRIEBE C, MULLIKEN J, BARNES P, MACDONALD D, FOLKMAN J, EZEKOWITZ A. Spastic diplegia as a complication of interferon alpha-2a treatment of hemangiomas of infancy. J Pediatrics 1998;132:527-530.
8. CAZZOLA M, BAROSI G, BERGAMASCHI G, DEZZA L, PALESTRA P, POLINO G, RAMELLA S, SPRIANO P, ASCARI E. Iron loading in congenital dyserythropoietic anaemias and congenital sideroblastic anaemias. Br J Haematol 1983;54:649-654.
9. WICKRAMASINGHE S. Dyserythropiesis and congenital dyserythropoietic anaemias. Br J Haematol 1997;98:785-797.
10. DEUGNIER Y, LOREAL O, TURLIN B, GUYADER D, JOUANOLLE H, MOIRAND R, JACQUELINET C, BRISSOT P. Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 1992;102:2050-2059.
11. SALOUM T, LAVABRE-BERTRAND T, PAGEAUX G, BISMUTH M, LARREY D, BLANC P. Evolution du bilan martial au cours et au decours du traitement par interferon (IFN) et ribavirine chez les malades ayant une hepatite chronique virale C (Abstract). Gastroenterol Clin Biol 2002;26(HS1), A96.
12. DGANY O, AVIDAN N, DELAUNAY J, et al. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Am J Hum Genet 2002;71:1467-1474.
13. RAPPAPORT A. Hepatic blood flow: morphological aspects and physiological regulation. Int Rev Physiol 1980;21:1-63.