Substantial decrease of psychiatric comorbidity in chronic alcoholics upon integrated outpatient treatment - Results of a prospective study

Journal of Psychiatric Research

Volumn 38, Issue 6, 2004, Pages 619-635

  Wagner, Thilo ^a   Krampe, Henning ^a   Stawicki, Sabina ^a   Reinhold, Jennifer ^a   Jahn, Henriette ^a   Mahlke, Kristin ^a   Barth, Ulrike ^a   Sieg, Sonja ^a   Maul, Oliver ^a   Galwas, Claudia ^a   Aust, Carlotta ^a   Kröner Herwig, Birgit ^a   Brunner, Edgar ^a   Poser, Wolfgang ^a   Henn, Fritz ^b   Rüther, Eckart ^a   Ehrenreich, Hannelore ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Chronic alcohol dependence; Chronic psychiatric illness; Chronicity; Comorbid personality disorders; Outpatient alcoholism treatment; Prognosis

Indexed keywords

ABSTINENCE; ALCOHOLISM; ANXIETY DISORDER; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DETOXIFICATION; DRINKING; FOLLOW UP; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MEDICAL ASSESSMENT; OUTPATIENT; PERSONALITY DISORDER; PRIORITY JOURNAL; PROBABILITY; PROSPECTIVE STUDY; RELAPSE;

ADULT; ALCOHOLISM; COMORBIDITY; FEMALE; HUMANS; MALE; MIDDLE AGED; OUTPATIENTS; PERSONALITY DISORDERS; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 5344244762     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2004.04.007     Document Type: Article

References (103)

1. Barlow D.H. Anxiety and its disorders: the nature and treatment of anxiety and panic. 1988;The Guilford Press, New York
2. Booth B.M., Russell D.W., Soucek S., Laughlin P.R. Social support and outcome of alcoholism treatment: an exploratory analysis. American Journal of Drug and Alcohol Abuse. 18(1):1992;87-101
3. Booth B.M., Yates W.R., Petty F., Brown K. Patient factors predicting early alcohol-related readmissions for alcoholics: role of alcoholism severity and psychiatric co-morbidity. Journal of Studies on Alcohol. 52(1):1991;37-43
4. Bowen R.C., D'Arcy C., Keegan D., Senthilselvan A. A controlled trial of cognitive behavioral treatment of panic in alcoholic inpatients with comorbid panic disorder. Addictive Behaviors. 25(4):2000;593-597
5. Bronisch T., Mombour W. The modern assessment of personality disorders: II. Reliability and validity of personality disorders. Psychopathology. 31(6):1998;293-301
6. Brown R.A., Evans D.M., Miller I.W., Burgess E.S., Mueller T.I. Cognitive-behavioral treatment for depression in alcoholism. Journal of Consulting and Clinical Psychology. 65(5):1997;715-726
7. Brunner E., Domhof S., Langer F. Nonparametric analysis of longitudinal data in factorial experiments. 2002;John Wiley, New York
8. Brunner E., Langer F. Nonparametric analysis of ordered categorical data in designs with longitudinal observations and small sample sizes. Biometrical Journal. 42:2000;663-675
9. Burtscheidt W., Woelwer W., Schwarz R., Strauss W., Loell A., Luethcke H., et al. Out-patient behaviour therapy in alcoholism: relapse rates after 6 months. Acta Psychiatrica Scandinavica. 103(1):2001;24-29
10. Cacciola J.S., Alterman A.I., Rutherford M.J., Snider E.C. Treatment response of antisocial substance abusers. Journal of Nervous and Mental Disease. 183(3):1995;166-171
11. Curran G.M., Booth B.M. Longitudinal changes in predictor profiles of abstinence from alcohol use among male veterans. Alcoholism: Clinical and Experimental Research. 23(1):1999;141-143
12. Derogatis LR. SCL-90-R. Administration, scoring and procedures manual 1. Baltimore, MD: Clinical Psychometrics Research, 1977
13. DiNardo P.A., Barlow D.H. Anxiety Disorders Interview Schedule - Revised ADIS-R. 1988;Graywind Publications, Albany, NY
14. Dixon L., McNary S., Lehman A. One-year follow-up of secondary versus primary mental disorder in persons with comorbid substance use disorders. American Journal of Psychiatry. 154(11):1997;1610-1612
15. Doering W.K., Herzenstiel M.-N., Krampe H., Jahn H., Pralle L., Sieg S., et al. Persistent alterations of vasopressin and NT-pro-ANP plasma levels in long-term abstinent alcoholics. Alcoholism Clinical and Experimental Research. 27(5):2003;849-861
16. Domhof S., Brunner E., Osgood D.W. Rank procedures for repeated measures with missing values. Sociological Methods and Research. 30(3):2002;367-393
17. Drake R.E., Essock S.M., Shaner A., Carey K.B., Minkoff K., Kola L., et al. Implementing dual diagnosis services for clients with severe mental illness. Psychiatric Services. 52(4):2001;469-476
18. Drake R.E., Mercer-McFadden C., Mueser K.T., McHugo G.J., Bond G.R. Review of integrated mental health and substance abuse treatment for patients with dual disorders. Schizophrenia Bulletin. 24(4):1998;589-608
19. Driessen M., Arolt V., John U., Veltrup C., Dilling H. Psychiatric comorbidity in hospitalized alcoholics after detoxification treatment. European Addiction Research. 2:1996;17-23
20. Ehrenreich H., Krampe H., Wagner T., Jahn H., Jacobs S., Maul O., et al. Outpatient long-term intensive therapy for alcoholics, OLITA: re-considering severe alcoholism, disease and treatment. Suchtmedizin in Forschung und Praxis. 2(4):2000;221-222
21. Ehrenreich H., Mangholz A., Schmitt M., Lieder P., Völkel W., Rüther E., et al. OLITA: an alternative in the treatment of therapy-resistant chronic alcoholics. First evaluation of a new approach. European Archives of Psychiatry and Clinical Neuroscience. 247(1):1997;51-54
22. Ehrenreich H., Schuck J., Stender N., Pilz J., Gefeller O., Schilling L., et al. Endocrine and hemodynamic effects of stress versus systemic CRF in alcoholics during early and medium term abstinence. Alcoholism Clinical and Experimental Research. 21(7):1997;1285-1293
23. Finney J.W., Moos R.H. The long-term course of treated alcoholism: I. Mortality, relapse and remission rates and comparisons with community controls. Journal of Studies on Alcohol. 52(1):1991;44-54
24. Fisher M.S., Bentley K.J. Two group therapy models for clients with a dual diagnosis of substance abuse and personality disorder. Psychiatric Services. 47(11):1996;1244-1250
25. Fleiss J.L. Statistical methods for rates and proportions. 1981;Wiley, New York
26. Franke G.H. SCL-90-R: Die Symptom-Checkliste von Derogatis - Deutsche Version. 1995;Beltz Test, Göttingen
27. Greenfield S.F., Weiss R.D., Muenz L.R., Vagge L.M., Kelly J.F., Bello L.R., et al. The effect of depression on return to drinking: a prospective study. Archives of General Psychiatry. 55(3):1998;259-265
28. Gsellhofer B., Küfner H., Vogt M., Weiler D. European Addiction Severity Index - EuropASI. 1999;Schneider-Verlag Hohengehren, Baltmannsweiler
29. Hasin D.S., Grant B.F., Endicott J. Lifetime psychiatric comorbidity in hospitalized alcoholics: subject and familial correlates. International Journal of the Addictions. 23(8):1988;827-850
30. Hasin D.S., Grant B.F. Major depression in 6050 former drinkers - Association with past alcohol dependence. Archives of General Psychiatry. 59(9):2002;794-800
31. Hasin D.S., Liu X., Nunes E., McCloud S., Samet S., Endicott J. Effects of major depression on remission and relapse of substance dependence. Archives of General Psychiatry. 59(4):2002;375-380
32. Hasin D.S., Tsai W.-Y., Endicott J., Mueller T.I., Coryell W., Keller M. The effects of major depression on alcoholism: five-year course. American Journal on Addictions. 5(2):1996;144-155
33. Hesselbrock M.N., Meyer R.E., Keener J.J. Psychopathology in hospitalized alcoholics. Archives of General Psychiatry. 42(11):1985;1050-1055
34. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics. 6:1979;65-70
35. Hunter E.E., Powell B.J., Penick E.C., Nickel E.J., Liskow B.I., Cantrell P.J., et al. Comorbid psychiatric diagnosis and long-term drinking outcome. Comprehensive Psychiatry. 41(5):2000;334-338
36. Jacobsen L.K., Southwick S.M., Kosten T.R. Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. American Journal of Psychiatry. 158(8):2001;1184-1190
37. Kendler K.S., Walters E.E., Neale M.C., Kessler R.C., Heath A.C., Eaves L.J. The structure of the genetic and environmental risk factors for six major psychiatric disorders in women: phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry. 52(5):1995;374-383
38. Kessler R.C., Crum R.M., Warner L.A., Nelson C.B., Schulenberg J., Anthony J.C. Lifetime co-occurrence of DS M-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Archives of General Psychiatry. 54(4):1997;313-321
39. Kleinbaum D.G. Survival analysis: a self-learning text. 1996;Springer, New York
40. Krampe H., Wagner T., Küfner H., Jahn H., Stawicki S., Reinhold J., et al. Therapist rotation - a new element in the outpatient treatment of alcoholism. Substance Use and Misuse. 39(1):2004;135-178
41. Kranzler H.R., Del Boca F.K., Rounsaville B.J. Comorbid psychiatric diagnosis predicts three-year outcomes in alcoholics: a posttreatment natural history study. Journal of Studies on Alcohol. 57(6):1996;619-626
42. Kranzler H.R., Rounsaville B.J. Dual Diagnosis and treatment. 1998;Marcel Dekker, New York
43. Kushner M.G., Abrams K., Borchardt C. The relationship between anxiety disorders and alcohol use disorders: a review of major perspectives and findings. Clinical Psychology Review. 20(2):2000;149-171
44. Lehman A.F., Dixon L.B. Double jeopardy: chronic mental illness and substance use disorders. 1995;Harwood Academic Publishers, Chur
45. Lepine J.-P., Pelissolo A. Social phobia and alcoholism: a complex relationship. Journal of Affective Disorders. 50:1998;S23-S28
46. Lewis C.E., Smith E., Kercher C., Spitznagel E. Assessing gender interactions in the prediction of mortality in alcoholic men and women: a 20-year follow-up study. Alcoholism: Clinical and Experimental Research. 19(5):1995;1162-1172
47. Longabaugh R., Rubin A., Malloy P., Beattie M., Clifford P.R., Noel N. Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. Alcoholism: Clinical and Experimental Research. 18(4):1994;778-785
48. Loosen P.T., Dew B.W., Prange A.J. Long-term predictors of outcome in abstinent alcoholic men. American Journal of Psychiatry. 147(12):1990;1662-1666
49. Maier W., Merikangas K. Co-occurrence and cotransmission of affective disorders and alcoholism in families. British Journal of Psychiatry. 168(Suppl 30):1996;93-100
50. Marcus R., Peritz E., Gabriel K.R. On closed testing procedures with special reference to ordered analysis of variance. Biometrika. 63:1976;655-660
51. Margraf J. MiniDIPS: Diagnostisches Kurz-Interview bei psychischen Störungen. 1994;Springer, Berlin
52. Marubini E., Valsecchi M.G. Analysing survival data from clinical trials and observational studies. 1995;John Wiley, Chichester
53. Massion A.O., Dyck I.R., Shea M.T., Phillips K.A., Warshaw M.G., Keller M.B. Personality disorders and time to remission in generalized anxiety disorder, social phobia and panic disorder. Archives of General Psychiatry. 59(5):2002;434-440
54. McHugo G.J., Drake R.E., Teague G.B., Xie H. Fidelity to assertive community treatment and client outcomes in the New Hampshire dual disorders study. Psychiatric Services. 50(6):1999;818-824
55. McKay J.R., McLellan A.T. Deciding where to start: working with polyproblem individuals. Miller W.R., Heather N. Treating addictive behaviors. 1998;173-186 Plenum Press, New York, London
56. McLellan A.T., Kushner H., Metzger D., Peters R., Smith I., Grissom G., et al. The fith edition of the Addiction Severity Index. Journal of Substance Abuse Treatment. 9(3):1992;199-213
57. Mercier C., Brochu S., Girard M., Gravel J., Ouellet R., Paré R. Profiles of alcoholics according to the SCL-90-R: a confirmative study. International Journal of the Addictions. 27(11):1992;1267-1282
58. Merikangas K.R., Stevens D.E., Fenton B., Stolar M., O'Malley S., Woods S.W., et al. Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychological Medicine. 28(4):1998;773-788
59. Moggi F., Ouimette P.C., Finney J.W., Moos R.H. Effectiveness of treatment for substance abuse and dependence for dual diagnosis patients: a model of treatment factors associated with one-year outcomes. Journal of Studies on Alcohol. 60(6):1999;856-866
60. Moggi F., Ouimette P.C., Moos R.H., Finney J.W. Dual diagnosis patients in substance abuse treatment: relationship of general coping and substance-specific coping to 1-year outcomes. Addiction. 94(12):1999;1805-1816
61. Moos R.H., Finney J.W., Ouimette P.C., Suchinsky R.T. A comparative evaluation of substance abuse treatment: I. Treatment orientation, amount of care, and 1-year outcomes. Alcoholism: Clinical and Experimental Research. 23(3):1999;529-536
62. Morgenstern J., Langenbucher J., Labouvie E., Miller K.J. The comorbidity of alcoholism and personality disorders in a clinical population: prevalence and relation to alcohol typology variables. Journal of Abnormal Psychology. 106(1):1997;74-84
63. Mueller T.I., Lavori P.W., Keller M.B., Swartz A., Warshaw M., Hasin D., et al. Prognostic effect of the variable course of alcoholism on the 10-year course of depression. American Journal of Psychiatry. 151(5):1994;701-706
64. Mueser K.T., Kavanagh D Treating comorbidity of alcohol problems and psychiatric disorder. Heather N., Peters T.J., Stockwell T. International handbook of alcohol dependence and problems. 2001;627-647 Wiley, Chichester
65. Nace E.P., Davis C.W., Gaspari J.P. Axis II comorbidity in substance abusers. American Journal of Psychiatry. 148(1):1991;118-120
66. Najavits L.M., Weiss R.D., Shaw S.R., Muenz L.R. Seeking safety: outcome of a new cognitive-behavioral psychotherapy for women with posttraumatic stress disorder and substance dependence. Journal of Traumatic Stress. 11(3):1998;437-456
67. Nurnberg H.G., Rifkin A., Doddi S. A systematic assessment of the comorbidity of DSM-III-R personality disorders in alcoholic outpatients. Comprehensive Psychiatry. 34(6):1993;447-454
68. O'Sullivan K., Rynne C., Miller J., O'Sullivan S., Fitzpatrick V., Hux M., et al. A follow-up study on alcoholics with and without co-existing affective disorder. British Journal of Psychiatry. 152:1988;813-819
69. Ouimette P.C., Gima K., Moos R.H., Finney J.W. A comparative evaluation of substance abuse treatment IV. The effect of comorbid psychiatric diagnoses on amount of treatment, continuing care, and 1-year outcomes. Alcoholism: Clinical and Experimental Research. 23(3):1999;552-557
70. Ouimette P.R., Brown P.J., Najavits L.M. Course and treatment of patients with both substance use and posttraumatic stress disorders. Addictive Behaviours. 23:1998;785-795
71. Penick E.C., Powell B.J., Nickel E.J., Bingham S.F., Riesenmy K.R., Read M.R., et al. Co-morbidity of lifetime psychiatric disorder among male alcoholic patients. Alcoholism: Clinical and Experimental Research. 18(6):1994;1289-1293
72. Powell B.J., Landon J.F., Cantrell P.J., Penick E.C., Nickel E.J., Liskow B.I., et al. Prediction of drinking outcomes for male alcoholics after 10 to 14 years. Alcoholism: Clinical and Experimental Research. 22(3):1998;559-566
73. Powell B.J., Penick E.C., Nickel E.J., Liskow B.I., Riesenmy K.R., Campion S.L., et al. Outcomes of co-morbid alcoholic men: a 1-year follow-up. Alcoholism: Clinical and Experimental Research. 16(1):1992;131-138
74. Preisig M., Fenton B.T., Stevens D.E., Merikangas K.R. Familial relationship between mood disorders and alcoholism. Comprehensive Psychiatry. 42(2):2001;87-95
75. Prescott C.A., Aggen S.H., Kendler K.S. Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins. Archives of General Psychiatry. 57(8):2000;803-811
76. Project MATCH Research Group. Matching alcoholism treatments to client heterogeneity: Project MATCH Posttreatment drinking outcomes. Journal of Studies on Alcohol 1997;58(1):7-29
77. Project MATCH Research Group. Matching alcoholism treatments to client heterogeneity: Project MATCH three-year drinking outcomes. Alcoholism: Clinical and Experimental Research 1998;22(6):1300-11
78. Randall C.L., Thomas S., Thevos A.K. Concurrent alcoholism and social anxiety disorder: a first step toward developing effective treatments. Alcoholism: Clinical and Experimental Research. 25(2):2001;210-220
79. Regier D.A., Farmer M.E., Rae D.S., Locke B.Z., Keith S.J., Judd L.L., et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA. 264(19):1990;2511-2518
80. Reich J.H., Green A.I. Effect of personality disorders on outcome of treatment. Journal of Nervous and Mental Disease. 179(2):1991;74-82
81. Reich J.H., Vasile R.G. Effect of personality disorders on the treatment outcome of Axis I conditions: an update. Journal of Nervous and Mental Disease. 181(8):1993;475-484
82. Ross H.E. DSM-III-R alcohol abuse and dependence and psychiatric comorbidity in Ontario: results from the Mental Health Supplement to the Ontario Health Survey. Drug and Alcohol Dependence. 39(2):1995;111-128
83. Ross H.E., Glaser F.B., Germanson T. The prevalence of psychiatric disorders in patients with alcohol and other drug problems. Archives of General Psychiatry. 45(11):1988;1023-1031
84. Rounsaville B.J., Kranzler H.R., Ball S., Tennen H., Poling J., Triffleman E. Personality disorders in substance abusers: relation to substance use. Journal of Nervous and Mental Disease. 186(2):1998;87-95
85. Ruiz P., Lile B., Matorin A.A. Treatment of a dually diagnosed gay male patient: a psychotherapy perspective. American Journal of Psychiatry. 159(2):2002;209-215
86. Scheurich A., Mueller M.J., Wetzel H., Anghelescu I., Klawe C., Ruppe A., et al. Reliability and validity of the German version of the European Addiction Severity Index (EuropASI). Journal of Studies on Alcohol. 61(6):2000;916-919
87. Schneider U., Altmann A., Baumann M., Bernzen J., Bertz B., Bimber U., et al. Comorbid anxiety and affective disorder in alcohol-dependent patients seeking treatment: the first Multicentre Study in Germany. Alcohol and Alcoholism. 36(3):2001;219-223
88. Swendsen J.D., Merikangas K.R. The comorbidity of depression and substance use disorders. Clinical Psychology Review. 20(2):2000;173-189
89. Teague G.B., Bond G.R., Drake R.E. Program fidelity in assertive community treatment: development and use of a measure. American Journal of Orthopsychiatry. 68(2):1998;216-232
90. Thevos A.K., Roberts J.S., Thomas S.E., Randall C.L. Cognitive behavioral therapy delays relapse in female socially phobic alcoholics. Addictive Behaviors. 25(3):2000;333-345
91. Tomasson K., Vaglum P. A nationwide representative sample of treatment-seeking alcoholics: a study of psychiatric comorbidity. Acta Psychiatrica Scandinavica. 92(5):1995;378-385
92. Toneatto T., Negrete J.C., Calderwood K. Diagnostic subgroups within a sample of comorbid substance abusers: correlates and characteristics. American Journal on Addictions. 9(3):2000;253-264
93. Verheul R. Co-morbidity of personality disorders in individuals with substance use disorders. European Psychiatry. 16(5):2001;274-282
94. Verheul R., van den Brink W., Koeter M.W.J., Hartgers C. Antisocial alcoholic patients show as much improvement at 14-month follow-up as non-antisocial alcoholic patients. American Journal on Addictions. 8(1):1999;24-33
95. Verheul R., Vandenbrink W., Hartgers C. Personality disorders predict relapse in alcoholic patients. Addictive Behaviors. 23(6):1998;869-882
96. Weisner C., McLellan A.T., Hunkeler E.M. Addiction Severity Index data from general membership and treatment samples of HMO members: one case of norming ASI. Journal of Substance Abuse Treatment. 19(2):2000;103-109
97. Weiss R.D., Griffin M.L., Greenfield S.F., Najavits L.M., Wyner D., Soto J.A., et al. Group therapy for patients with bipolar disorder and substance dependence: results of a pilot study. Journal of Clinical Psychiatry. 61(5):2000;361-367
98. Weiss R.D., Najavits L.M., Greenfield S.F. A relapse prevention group for patients with bipolar and substance use disorders. Journal of Substance Abuse Treatment. 16(1):1999;47-54
99. Weiss R.D., Najavits L.M., Mirin S.M. Substance abuse and psychiatric disorders. Frances R.J., Miller S.I. Clinical textbook of addictive disorders. 1998;291-318 The Guilford Press, New York, London
100. Wittchen H.-U., Essau C.A., von Zerssen D., Krieg J.-C., Zaudig M. Lifetime and six-month prevalence of mental disorders in the Munich Follow-up Study. European Archives of Psychiatry and Clinical Neuroscience. 241(4):1992;247-258
101. Wittchen H.-U., Nelson C.B., Lachner G. Prevalence of mental disorders and psychosocial impairments in adolescents and young adults. Psychological Medicine. 28(1):1998;109-126
102. Wittchen H.U., Wunderlich U., Gruschwitz S., Zaudig M. SKID-I. Strukturiertes Klinisches Interview für DSM-IV- Achse I. 1997;Hogrefe, Göttingen
103. Woelwer W., Burtscheidt W., Redner C., Schwarz R., Gaebel W. Out-patient behaviour therapy in alcoholism: impact of personality disorders and cognitive impairments. Acta Psychiatrica Scandinavica. 103(1):2001;30-37