Assessing the issue of instability due to Michael adduct formation in novel chemical entities possessing a carbon-carbon double bond during early drug development - Applicability of common laboratory analytical protocols

Biomedical Chromatography

Volumn 22, Issue 9, 2008, Pages 960-976

  Polepally, Akshanth Reddy ^a   Pavan Kumar, Venkata V ^a   Bhamidipati, Ravikanth ^a   Kota, Jagannath ^a   Naveed, Shaik Abdul ^a   Reddy, Karnati Harinder ^a   Mamidi, Rao N V S ^a   Selvakumar, N ^a   Mullangi, Ramesh ^a   Srinivas, Nuggehally R ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Michael adduct; NCEs; , unsaturated carbonyl group

Indexed keywords

BIOCHEMISTRY; CARBON; CHEMICAL BONDS; STRUCTURAL OPTIMIZATION; UNSATURATED COMPOUNDS;

A-CARBON; ADDUCT FORMATION; ANALYTICAL PROTOCOLS; CARBON-CARBON DOUBLE BONDS; CARBONYL GROUPS; CHEMICAL ENTITY; DRUG DEVELOPMENT; MICHAEL ADDUCTS; NOVEL CHEMICAL ENTITY; Α,Β-UNSATURATED CARBONYL GROUP;

NUCLEOPHILES;

CARBON; DRF 2817; DRF 6196; DRF 6748; DRF 6784; DRF 6823; DRF 6824; DRF 6825; DRF 6826; DRF 6910; DRF 6959; DRF 6990; DRF 6991; DRF 8129; DRF 8130; DRF 8269; DRF 8270; DRF 8356; GLUTATHIONE; LINEZOLID; NEW DRUG; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BINDING; CONTROLLED STUDY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; MICHAEL ADDITION; MOLECULAR STABILITY; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 53349142422     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1015     Document Type: Article

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