Attenuation of monocyte proinflammatory cytokine responses to Neisseria meningitidis in children by erythropoietin

Clinical and Experimental Immunology

Volumn 154, Issue 2, 2008, Pages 187-191

  Schultz, C ^a   Zimmer, J ^a   Hartel C ^a   Rupp, J ^a   Temming, P ^a   Strunk, T ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Erythropoietin; IL 6; N. meningitides; TNF

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; INTERLEUKIN 6; RECOMBINANT ERYTHROPOIETIN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; BLOOD LEVEL; CHILD; CYTOKINE PRODUCTION; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; INFANT; MENINGOCOCCOSIS; MICROBIAL ATTENUATION; MONOCYTE; NEISSERIA MENINGITIDIS; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; AGE FACTORS; CELLS, CULTURED; CHILD, PRESCHOOL; CYTOKINES; ERYTHROPOIETIN, RECOMBINANT; HUMANS; INFANT; INFANT, NEWBORN; INTERLEUKIN-6; MENINGOCOCCAL INFECTIONS; MONOCYTES; NEISSERIA MENINGITIDIS; SEROTYPING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 53349109070     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03760.x     Document Type: Article

References (16)

1. Kaplan SL, Schutze GE, Leake JA et al. Multicenter surveillance of invasive meningococcal infections in children. Pediatrics 2006 118 : e979.
2. Pollard AJ, Galassini R, Rouppe van der Voort EM et al. Cellular immune responses to Neisseria meningitidis in children. Infect Immun 1999 67 : 2452 63.
3. Woods CR. Neisseria meningitidis (meningococcus). In : Kliegmann RM, Behrmann RE, Jenson HB, Stanton BF, eds. Nelson textbook of pediatrics. Philadelphia : Saunders Elsevier, 2007 : 1164 9.
4. Schultz C, Rott C, Temming P, Schlenke P, Möller JC, Bucsky P. Enhanced interleukin-6 and interleukin-8 synthesis in term and preterm infants. Pediatr Res 2002 51 : 317 22.
5. Schultz C, Temming P, Bucsky P, Göpel W, Strunk T, Härtel C. Immature antiinflammatory response in neonates. Clin Exp Immunol 2004 135 : 130 6.
6. Strunk T, Härtel C, Schultz C. Does erythropoietin protect the preterm brain? Arch Dis Child Fetal Neonatal Ed 2004 89 : F364 6.
7. Robinson K, Neal KR, Howard C et al. Characterization of humoral and cellular immune response elicited by meningococcal carriage. Infect Immun 2002 70 : 1301 9.
8. Schultz C. Correspondence responding to correspondence relating to Dembinski et al. Pediatr Res 2003 53 : 866 8.
9. Härtel C, Adam N, Strunk T, Temming P, Müller-Steinhardt M, Schultz C. Cytokine responses correlate differentially with age in infancy and early childhood. Clin Exp Immunol 2005 142 : 446 53.
10. Ertel W, Kremer JP, Kenney J et al. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 1995 85 : 1341 7.
11. Westendorp RG, Langermans JA, de Bel CE et al. Release of tumor necrosis factor: an innate host characteristic that may contribute to the outcome of meningococcal disease. J Infect Dis 1995 171 : 1057 60.
12. Pathan N, Hemingway CA, Alizadeh AA et al. Role of interleukin-6 in myocardial dysfunction of meningococcal septic schock. Lancet 2004 363 : 203 9.
13. Strunk T, Härtel C, Temming P, Matzke N, Zimmer J, Schultz C. Erythropoietin inhibits cytokine production of human leukocytes. Acta Paediatr 2008 97 : 16 20.
14. Maier RF, Obladen M, Müller-Hansen I et al.,. Early treatment with erythropoietin β ameliorates anemia and reduces transfusion requirements in infants with birth weights below 1000 g. J Pediatr 2002 141 : 8 15.
15. Ehrenreich H, Hasselblatt M, Dembowski C et al. Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 2002 8 : 495 505.
16. Corwin HL, Gettinger A, Fabian TC et al. Efficacy and safety of Epoetin alfa in critically ill patients. N Engl J Med 2007 357 : 965 76.