Lysosomal trapping of amodiaquine: Impact on transport across intestinal epithelia models

Biopharmaceutics and Drug Disposition

Volumn 29, Issue 6, 2008, Pages 324-334

  Hayeshi, Rose ^a   Masimirembwa, Collen ^b   Mukanganyama, Stanley ^a   Ungell, Anna Lena B ^c  

^a UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^b African Institute of Biomedical Science and Technology   (Zimbabwe)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Amodiaquine; Caco 2; Low recovery; Lysosomotropy; Rat jejunum

Indexed keywords

AMMONIUM CHLORIDE; AMODIAQUINE; BOVINE SERUM ALBUMIN; POLY(METHYL METHACRYLATE);

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BINDING AFFINITY; CELL PH; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG PENETRATION; DRUG STRUCTURE; DRUG TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE EPITHELIUM; JEJUNUM; LYSOSOME; MONOLAYER CULTURE; NONHUMAN; PHYSICAL CHEMISTRY; RAT;

AMMONIUM CHLORIDE; AMODIAQUINE; ANIMALS; ANTIMALARIALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DOGS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL MUCOSA; JEJUNUM; LYSOSOMES; PERMEABILITY; PLASTICS; RATS; SERUM ALBUMIN, BOVINE;

EID: 53349107610     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.616     Document Type: Article

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