Development of a simultaneous liquid-liquid extraction and chiral derivatization method for stereospecific GC-MS analysis of amphetamine-type stimulants in human urine using fractional factorial design

Biomedical Chromatography

Volumn 22, Issue 9, 2008, Pages 1035-1042

  Wan Aasim, W Raihana ^a   Gan, S H ^a   Tan, S C ^b  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^b SCHOOL OF PHYSICS   (Malaysia)

Author keywords

Amphetamine type stimulants; Chiral derivatization; Experimental design; Fractional factorial; Stereospecific analysis

Indexed keywords

BODY FLUIDS; GAS CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SODIUM HYDROXIDE; SOLVENT EXTRACTION; STATISTICS;

AMPHETAMINE-TYPE STIMULANT; ANALYTES; CHIRAL DERIVATIZATION; DERIVATIZATION REAGENT; DERIVATIZATIONS; FRACTIONAL FACTORIALS; HUMAN URINE; LIQUID-LIQUID EXTRACTION; STEREOSPECIFIC; STEREOSPECIFIC ANALYSIS;

SODIUM CHLORIDE;

AMPHETAMINE; CHLORINE DERIVATIVE; SODIUM CHLORIDE; SODIUM HYDROXIDE; TRIETHYLAMINE;

ANALYSIS OF VARIANCE; ARTICLE; CALIBRATION; CHIRAL CHROMATOGRAPHY; CORRELATION COEFFICIENT; DERIVATIZATION; FACTORIAL DESIGN; INCUBATION TEMPERATURE; INCUBATION TIME; LIQUID LIQUID EXTRACTION; MASS FRAGMENTOGRAPHY; REFERENCE VALUE; REPRODUCIBILITY; SAMPLING; SENSITIVITY ANALYSIS; SOLVENT EXTRACTION; STEREOSPECIFICITY; URINALYSIS;

EID: 53349098144     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1073     Document Type: Article

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