Expression of methyl CpG binding protein 2 (Mecp2) during the postnatal development of the mouse brainstem

Brain Research

Volumn 1236, Issue , 2008, Pages 176-184

  Dura, Emmanuelle ^a,b   Villard, Laurent ^a,b   Roux, Jean Christophe ^a,b  

^a INSERM   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Brainstem; Medulla oblongata; Ontogenesis; Pons

Indexed keywords

DNA BINDING PROTEIN; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN STEM; CONTROLLED STUDY; GENE; GENE MUTATION; GENETIC TRANSCRIPTION; MALE; MECP2 GENE; MEDULLA OBLONGATA; MENTAL DEFICIENCY; MOUSE; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETT SYNDROME;

RODENTIA;

EID: 53249149102     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.08.021     Document Type: Article

References (42)

1. Akbarian S., Chen R.Z., Gribnau J., Rasmussen T.P., Fong H., Jaenisch R., and Jones E.G. Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex. Neurobiol. Dis. 8 (2001) 784-791
2. Carney R.M., Wolpert C.M., Ravan S.A., Shahbazian M., Ashley-Koch A., Cuccaro M.L., Vance J.M., and Pericak-Vance M.A. Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr. Neurol. 28 (2003) 205-211
3. Cassel S., Revel M.O., Kelche C., and Zwiller J. Expression of the methyl-CpG-binding protein MeCP2 in rat brain. An ontogenetic study. Neurobiol. Dis. 15 (2004) 206-211
4. Chahrour M., and Zoghbi H.Y. The story of Rett syndrome, from clinic to neurobiology. Neuron 56 (2007) 422-437
5. Chen W.G., Chang Q., Lin Y., Meissner A., West A.E., Griffith E.C., Jaenisch R., and Greenberg M.E. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302 (2003) 885-889
6. Collins A.L., Levenson J.M., Vilaythong A.P., Richman R., Armstrong D.L., Noebels J.L., David Sweatt J., and Zoghbi H.Y. Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum. Mol. Genet. 13 (2004) 2679-2689
7. Donkelaar H.J.T., Lammens M., Cruysberg J.R.M., and Cremers W.J.R. Development and Developmental Disorders of the Brain Stem in Clinical neuroembryologie Springer (2006), Heidelberg Press, Berlin
8. Dotti M.T., Guideri F., Acampa M., Orrico A., Battisti C., and Federico A. Autonomic dysfunction in mental retardation and spastic paraparesis with MECP2 mutation. J. Child. Neurol. 19 (2004) 964-966
9. Erlandson A., and Hagberg B. MECP2 abnormality phenotypes: clinicopathologic area with broad variability. J. Child. Neurol. 20 (2005) 727-732
10. Gomot M., Gendrot C., Verloes A., Raynaud M., David A., Yntema H.G., Dessay S., Kalscheuer V., Frints S., Couvert P., Briault S., Blesson S., Toutain A., Chelly J., Desportes V., and Moraine C. MECP2 gene mutations in non-syndromic X-linked mental retardation: phenotype-genotype correlation. Am. J. Med. Genet. A 123 (2003) 129-139
11. Guy J., Hendrich B., Holmes M., Martin J.E., and Bird A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27 (2001) 322-326
12. Guy J., Gan J., Selfridge J., Cobb S., and Bird A. Reversal of neurological defects in a mouse model of Rett syndrome. Science 315 (2007) 1143-1147
13. Horike S., Cai S., Miyano M., Cheng J.F., and Kohwi-Shigematsu T. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat. Genet. 37 (2005) 31-40
14. Julu P.O., and Witt Engerström I. Assessment of the maturity-related brainstem functions reveals the heterogeneous phenotypes and facilitates clinical management of Rett syndrome. Brain Develop. 27 (2005) S43-S53
15. Julu P.O., Kerr A.M., Hansen S., Apartopoulos F., and Jamal G.A. Functional evidence of brain stem immaturity in Rett syndrome. Eur. Child. Adolesc. Psychiatry 6 Suppl 1 (1997) 47-54
16. Julu P.O., Kerr A.M., Apartopoulos F., Al-Rawas S., Engerström I.W., Engerström L., Jamal G.A., and Hansen S. Characterisation of breathing and associated central autonomic dysfunction in the Rett disorder. Arch. Dis. Child. 85 (2001) 29-37
17. Jung B.P., Jugloff D., Zhang G., Logan R., Brown S., and Eubanks J.H. The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells. J. Neurobiol. 55 (2003) 86-96
18. Kerr A.M., Armstrong D.D., Prescott R.J., Doyle D., and Kearney D.L. Rett syndrome: analysis of deaths in the British survey. Eur. Chil. Adolesc. Psychiatry 6 S1 (1997) 71-74
19. Kishi N., and Macklis J.D. MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol. Cell. Neurosci. 27 (2004) 306-321
20. Lam C.W., Yeung W.L., Ko C.H., Poon P.M., Tong S.F., Chan K.Y., Lo I.F., Chan L.Y., Hui J., Wong V., Pang C.P., Lo Y.M., and Fok T.F. Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome. J. Med. Genet. 37 (2000) E41
21. LaSalle J.M., Goldstine J., Balmer D., and Greco C.M. Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. Hum. Mol. Genet. 10 (2001) 1729-1740
22. Laurvick C.L., de Klerk N., Bower C., Christodoulou J., Ravine D., Ellaway C., Williamson S., and Leonard H. Rett syndrome in Australia: a review of the epidemiology. J. Pediatr. 148 (2006) 347-352
23. Liu J., and Francke U. Identification of cis-regulatory elements for MECP2 expression. Hum. Mol. Genet. 15 (2006) 1769-1782
24. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (2001) 402-408
25. Medrihan L., Tantalaki E., Aramuni G., Sargsyan V., Dudanova I., Missler M., and Zhang W. Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. J. Neurophysiol. 99 (2008) 112-121
26. Mullaney B.C., Johnston M.V., and Blue M.E. Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain. Neuroscience 123 (2004) 939-949
27. Nan X., Ng H.H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., and Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393 (1998) 386-389
28. Nomura Y., Kimura K., Arai H., and Segawa M. Involvement of the autonomic nervous system in the pathophysiology of Rett syndrome. Eur. Child. Adolesc. Psychiatry 6S1 (1997) 42-46
29. Paterson D.S., Thompson E.G., Belliveau R.A., Antalffy B.A., Trachtenberg F.L., Armstrong D.D., and Kinney H.C. Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. J. Neuropathol. Exp. Neurol. 64 (2005) 1018-1027
30. Paxinos G., and Franklin K.B.J. The mouse brain in stereotaxic coordinates. (2nd ed.) (2001), Academic Press, San Diego, CA.
31. Pelka G.J., Watson C.M., Christodoulou J., and Tam P.P. Distinct expression profiles of Mecp2 transcripts with different lengths of 3¢UTR in the brain and visceral organs during mouse development. Genomics 85 (2005) 441-452
32. Rohdin M., Fernell E., Eriksson M., Albåge M., Lagercrantz H., and Katz-Salamon M. Disturbances in cardiorespiratory function during day and night in Rett syndrome. Pediatr. Neurol. 37 (2007) 338-344
33. Roux J.C., Mamet J., Perrin D., Peyronnet J., Royer C., Cottet-Emard J.M., Pequignot J.M., and Dalmaz Y. Neurochemical development of the brainstem catecholaminergic cell groups in rat. J. Neural. Transm. 110 (2003) 51-65
34. Samaco R.C., Fryer J.D., Ren J., Fyffe S., Chao H.T., Sun Y., Greer J.J., Zoghbi H.Y., and Neul J.L. A partial loss of function allele of Methyl-CpG-binding protein predicts a human neurodevelopmental syndrome. Hum. Mol. Genet. 17 (2008) 1718-1727
35. Shahbazian M.D., Antalffy B., Armstrong D.L., and Zoghbi H.Y. Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet. 11 (2002) 115-124
36. Stettner G.M., Huppke P., Brendel C., Richter D.W., Gärtner J., and Dutschmann M. Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice. J. Physiol. 579 (2007) 863-876
37. Van Esch H., Bauters M., Ignatius J., Jansen M., Raynaud M., Hollanders K., Lugtenberg D., Bienvenu T., Jensen L.R., Gecz J., Moraine C., Marynen P., Fryns J.P., and Froyen G. Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. Am. J. Hum. Genet. 77 (2005) 442-453
38. Viemari J.C., Roux J.C., Tryba A.K., Saywell V., Burnet H., Peña F., Zanella S., Bévengut M., Barthelemy-Requin M., Herzing L.B., Moncla A., Mancini J., Ramirez J.M., Villard L., and Hilaire G. Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. J. Neurosci. 25 (2005) 11521-11530
39. Villard L. MECP2 mutations in males. J. Med. Genet. 44 (2007) 417-423
40. Wang H., Chan S.A., Ogier M., Hellard D., Wang Q., Smith C., and Katz D.M. Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice. J. Neurosci. 26 (2006) 10911-10915
41. Weese-Mayer D.E., Lieske S.P., Boothby C.M., Kenny A.S., Bennett H.L., Silvestri J.M., and Ramirez J.M. Autonomic nervous system dysregulation: breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome. Pediatr. Res. 60 (2006) 443-449
42. Young J.I., Hong E.P., Castle J.C., Crespo-Barreto J., Bowman A.B., Rose M.F., Kang D., Richman R., Johnson J.M., Berget S., and Zoghbi H.Y. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 17551-17558