Sensitive liquid chromatographic determination of clarithromycin and 14-hydroxy clarithromycin in human plasma with tandem mass spectrometry

Journal of Liquid Chromatography and Related Technologies

Volumn 31, Issue 19, 2008, Pages 2955-2973

  Gurule, Sanjay ^a   Verma, P R P ^b   Monif, Tausif ^a   Khuroo, Arshad ^a   Partani, Pankaj ^a  

^a RANBAXY RESEARCH LABORATORIES   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

14 Hydroxy clarithromycin; Clarithromycin; Liquid chromatography; Macrolide; Precipitation; Tandem mass spectrometry

Indexed keywords

ACETONITRILE; AMMONIUM COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; CONCENTRATION (PROCESS); ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN); PRECIPITATION (CHEMICAL); SEPARATION; SPECTROMETRY;

14-HYDROXY CLARITHROMYCIN; CLARITHROMYCIN; MACROLIDE; PRECIPITATION; TANDEM MASS SPECTROMETRY;

PLASMAS;

14 HYDROXY CLARITHROMYCIN; ACETONITRILE; AMMONIUM FORMATE; CLARITHROMYCIN; DRUG METABOLITE; ERYTHROMYCIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRECIPITATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

EID: 53249145390     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070802424543     Document Type: Article

References (22)

1. Rodvold, K.A. Clinical Pharmacokinetics of clarithromycin. Clin. Pharmacokinetics. 1999, 37 (5), 385-398.
2. Piscitelli, S.C.; Danziger, L.H.; Rodvold, K.A. Clarithromycin and azithromycin: New macrolide antibiotics. Clin. Pharm. 1992, 11 (2), 137-152.
3. Hardy, D.J.; Guay, D.R.P.; Jones, R.N. Clarithromycin, a unique macrolide: A pharmacokinetic, macrobiological, and clinical overview. Diagn. Microbiol. Infect. Dis. 1992, 15 (1), 39-53.
4. Fernandez, P.B.; Ramer, R.; Rode, R.A.; Freiberg, L.A. Bioassay for A-56268 (TE-031) and identification of its major metabolite 14-hydroxy-6-O-methyl erythromycin. Eur. J. Clin. Microbiol. Infect. Dis. 1988, 7 (1), 73-76.
5. Davey, P.G. The pharmacokinetics of clarithromycin and its 14-OH metabolite. J. Hosp. Infect. 1991, 19 (1), 29-37.
6. Sturgill, M.G.; Rapp, R.P. Clarithromycin: Review of a new macrolide antibiotic with improved microbiologic spectrum and favorable pharmacokinetic and adverse effect profiles. Ann. Pharmacother. 1992, 26 (9), 1099-1108.
7. Amsden, G.W. Erythromycin, clarithromycin, and azithromycin: Are the differences real? Clin. Ther. 1996, 18 (1), 56-73.
8. Franschini, F.; Scaglione, F.; Demartini, G. Clarithromycin clinical pharmacokinetics. Clin. Pharma. 1993, 25 (3), 189-204.
9. Barradell, L.B.; Plosker, G.L.; McTavish, D. Clarithromycin: A review of its pharmacological properties and therapeutic use in Mycobacterium aviumintracellulare complex infection in patients with acquired immunodeficiency syndrome. Drugs. 1993, 46 (2), 289-312.
10. Fernandes, P.B.; Hardy, D.J.; McDaniel, D.; Hanson, C.W.; Swanson, R.N. In vitro and in vivo activities of clarithromycin against Mycobacterium avium. Antimicrob. Agents Chemother. 1989, 33 (9), 1531-1534.
11. Dautzenberg, B.; Truffot, C.; Legris, S.; Meyohas, M.C.; Berlie, H.C.; Mercat, A.; Chevret, S.; Grosset, J. Activity of clarithromycin against Mycobacterium avium infection in patients with acquired immune deficiency syndrome. Am. Rev. Respir. Dis. 1991, 144 (3), 564-569.
12. Chaisson, R.E.; Benson, C.A.; Dube, M.P.; Heifets, L.B.; Korvick, J.A.; Elkin, S.; Smith, T. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease: A Randomized, Double-Blind, Dose-ranging Study in patients with AIDS. Ann. Intern. Med. 1994, 121 (12), 905-911.
13. Hardy, D.J.; Swanson, R.N.; Rode, R.A.; Marsh, M.; Shipkowitz, N.L.; Clement, J.J. Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans. Antimicrob. Agents Chemother. 1990, 34 (7), 1407-1413.
14. Jorgensen, J.H.; Maher, L.A.; Howell, A.W. Activity of clarithromycin and its principal human metabolite against Haemophilus influenzae. Antimicrob. Agents Chemother. 1991, 35 (7), 1524-1526.
15. Benninger, P.; Cooper, A.; Moisan, R.; Patel, P.; Elvin, A.; Thiessen, J.J. A comparative clarithromycin bioavailability study: Determination of clarithromycin and 14-(R)-hydroxy clarithromycin under fasting and fed conditions. Int. J. Clin. Pharmacol. Ther. 2004, 42 (6), 342-349.
16. Lerner, F.E.; Caliendo, G.; Santagada, V.; Santana, G.S.M.; Moraes, M.E.A.; De Nucci, G. Clarithromycin bioequivalence study of two oral formulations in healthy human volunteers. Int. J. Clin. Pharmacol. Ther. 2000, 38 (7), 345-354.
17. Chu, S.Y.; Sennello, L.T.; Sonders, R.C. Simultaneous determination of clarithromycin and 14(R)-hydroxyclarithromycin in plasma and urine high-performance liquid chromatography with electrochemical detection. J. Chromatogr. 1991, 571 (1-2), 199-208.
18. Hedenmo, M.; Eriksson, B.M. Liquid chromatographic determination of the macrolide antibiotics roxithromycin and clarithromycin in plasma by automated solid-phase extraction and electrochemical detection. J. Chromatogr. 1995, 692 (1-2), 161-166.
19. Kees, F.; Spangler, S.; Wellenhofer, M. Determination of macrolides in biological matrices by high-performance liquid chromatography with electrochemical detection. J. Chromatogr. 1998, 812 (1-2), 287-293.
20. Sastre, T.J.; Guchelaar, H.J. Quantitative determination of the macrolide antibiotics erythromycin, roxithromycin, azithromycin and clarithromycin in human serum by high-performance liquid chromatography using pre-column derivatization with 9-fluorenyl- methyloxycarbonyl chloride and fluorescence detection. J. Chromatogr. B. Biomed. Sci. Appl. 1998, 720 (1-2), 89-97.
21. Wenkui, L.; Rettig, J.; Jiang, X.; Francisco, D.T.; Naidong, W. Liquid chromatographic-electrospray tandem mass spectrometric determination of clarithromycin in human plasma. Biomed. Chromatogr. 2006, 20 (11), 1242-1251.
22. Jiang, Y.; Wang, J.; Li, H.; Wang, Y.; Gu, J. Determination of clarithromycin in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Pharma. Biomed. Ana. 2007, 43 (4), 1460-1464.