Liquid chromatography-tandem mass spectrometry method for the determination of propranolol in human plasma and its application to a bioequivalence study

Journal of Liquid Chromatography and Related Technologies

Volumn 31, Issue 19, 2008, Pages 2927-2941

  Borges, Ney Carter Do Carmo ^a,b   Rigato, Hamilton Modesto ^a,b   De Oliveira, Paulo Renato ^c   Nogueira, Daniele Rubert ^c   Moreno, Ronilson Agnaldo ^a,b   Dalmora, Sergio Luiz ^c  

^a Synchrophar Assessoria e Desenvolvimento de Projetos Clinicos   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Bioequivalence; Liquid chromatography tandem mass spectrometry method; Liquid liquid extraction; Pharmacokinetics; Propranolol; Validation

Indexed keywords

ACETIC ACID; ACIDS; AMMONIUM COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); DRUG PRODUCTS; ELECTROSPRAY IONIZATION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMA (HUMAN); PLASMAS; RATE CONSTANTS; SEPARATION; SOLVENT EXTRACTION; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

BIOEQUIVALENCE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY METHOD; LIQUID-LIQUID EXTRACTION; PHARMACOKINETICS; PROPRANOLOL; VALIDATION;

LIQUID CHROMATOGRAPHY;

ACETIC ACID; ACETONITRILE; AMMONIUM ACETATE; METOPROLOL; PROPRANOLOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; ELECTROSPRAY; FEMALE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

EID: 53249137969     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070802424519     Document Type: Article

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