Glutamine reduces TNF-α by enhancing glutathione synthesis in lipopolysaccharide-stimulated alveolar epithelial cells of rats

Inflammation

Volumn 31, Issue 5, 2008, Pages 344-350

  Zhang, Feng ^a   Wang, Xinying ^a   Wang, Weiya ^a   Li, Ning ^a   Li, Jieshou ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Glutamine; Glutathione; Lipopolysaccharide; NF B; Tumor necrosis factor

Indexed keywords

BUTHIONINE SULFOXIMINE; GLUTAMINE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUTATHIONE METABOLISM; LUNG ALVEOLUS CELL TYPE 2; NONHUMAN; RAT;

ANIMALS; BUTHIONINE SULFOXIMINE; CYTOKINES; EPITHELIAL CELLS; GLUTAMINE; GLUTATHIONE; INFLAMMATION; LIPOPOLYSACCHARIDES; MODELS, BIOLOGICAL; NF-KAPPA B; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 53249111169     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-008-9084-0     Document Type: Article

References (30)

1. I. Rahman S. K. Biswas L. A. Jimenez M. Torres H. J. Forman 2005 Glutathione, stress responses, and redox signaling in Lung Inflammation Antioxid. Redox Signal. 7 42 59
2. I. Rahman 2005 Redox signaling in the lungs Antioxid. Redox Signal. 7 1 5
3. A. M. Cantin S. L. North R. C. Hubbard R. G. Crystal 1987 Normal alveolar epithelial lining fluid contains high levels of glutathione Am. J. Physiol. 63 152 157
4. I. Rahman B. Mulier P. S. Gilmour T. Watchorn K. Donaldson P. K. Jeffery 2001 Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB Biochem. Pharmacol. 62 787 794
5. M. Coeffier O. Miralles-Barrachina F. Le Pessot O. Lalaude M. Daveau A. Lavoinne 2001 Influence of glutamine on cytokine production by human gut in vitro Cytokine 13 148 154
6. P. E. Wischmeyer J. Riehm K. D. Singleton H. Ren M. W. Musch M. Kahana 2003 Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells Nutrition 19 1 6
7. K. D. Singleton V. E. Beckey P. E. Wischmeyer 2005 Glutamine prevents activation of NF-κB and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) Shock 24 583 589
8. Y. H. Cao Z. L. Feng A. Hoos V. S. Klimberg 1998 Glutamine enhances gut glutathione production J. Parenter. Enter. Nutr. 22 224 227
9. M. Moon T. Pritts A. Salzman J. Fischer P. O. Hasselgren 1998 Glutamine prevents LPS-induced NF-κB activation in human intestinal epithelial cells Gastroenterology 114 A1410 A1411
10. R. Babu S. Eaton D. P. Drake L. Spitz A. Pierro 2001 Glutamine and glutathione counteract the inhibitory effects of mediators of sepsis in neonatal hepatocytes J. Pediatr. Surg. 36 282 286
11. L. G. Dobbs R. Gonzalez M. C. Williams 1986 An improved method for isolating type II cells in high yield and purity Am. Rev. Respir. Dis. 134 141 145
12. E. Schreiber P. Matthias M. M. Müller W. Schaffner 1989 Rapid detection of nuclear binding proteins with mini-extracts prepared from a small number of cell Nucleic Acids Res. 17 6419
13. J. J. Haddad 2001 L-Buthionine-(S, R)-sulfoximine, an irreversible inhibitor of γ-glutamylcysteine sythetase, augments LPS-mediated pro-inflammatory cytokine biosynthesis: evidence for the implication of an IκB-α/NF-κB insensitive pathway Eur. Cytokine Netw. 12 614 624
14. O. Lesur K. Arsalane D. Lane 1996 Lung alveolar epithelial cell migration in vitro: modulators and regulation processes Am. J. Physiol. 270 L311 L319
15. G. S. Warshamana M. Corti A. R. Brody 2001 TNF-alpha, PDGF, and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: tnf-alpha induces TGF-beta(1) Exp. Mol. Pathol. 71 13 33
16. I. Rahman 2002 Oxidative stress, transcription factors and chromatin remodelling in lung inflammation Biochem. Pharmacol. 64 935 942
17. F. Hammarqvist J. Luo I. A. Cotgreave K. Anderson J. Wernerman 1997 Skeletal muscle glutathione is depleted in critically ill patients Crit. Care Med. 25 78 84
18. N. Manhart K. Vierlinger A. Spittler H. Bergmeister T. Sautner E. Roth 2000 Oral feeding with glutamine prevents lymphocyte and glutathione depletion of peyer's patches in endotoxemic mice Ann. Surg. 234 92 97
19. E. Bunnel E. R. Pacht 1993 Oxidised glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome Am. Rev. Respir. Dis. 148 1174 1178
20. R. Luthen J. H. Grendel C. Niederau D. Haussinger 1998 Trypsinogen activation and glutathione content are linked to pancreatic injury in models of bilary acute pancreatitis Int. J. Pancreatol. 24 193 202
21. S. K. Biswas D. Mcclure L. A. Jimenez I. L. Megson I. Rahman 2005 Curcumin induces glutathione biosynthesis and inhibits NF-κB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radicals scavenging activity Antioxid. Redox Signal. 7 32 41
22. J. J. Haddad S. C. Land 2002 Redox signaling-mediated regulation of lipopolysaccharide-induced proinflammatory cytokine biosynthesis in alveolar epithelial cells Antioxid. Redox Signal. 4 179 193
23. K. Rouse E. Nwokedi J. E. Woodliff J. Epstein V. S. Klimberg 1995 Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism Ann. Surg. 221 420 426
24. C. Goeters A. Wenn N. Mertes C. Wempe H. Van Aken P. Stehle 2004 Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients Crit. Care Med. 30 2032 2037
25. Y. N. Lai S. L. Yeh M. T. Lin H. F. Shang C. L. Yeh W. J. Chen 2004 Glutamine supplementation enhances mucosal immunity in rats with gut-derived sepsis Nutrition 20 286 291
26. W. K. Chang K. D. Yang H. Chuang J. T. Jan M. F. Shaio 2002 Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and Bcl-2 levels Clin. Immunol. 104 151 160
27. M. P. Glauser G. Zanett J. D. Baumgartner J. Cohen 1991 Septic shock: pathogenesis Lancet 338 732 736
28. L. R. Pena D. B. Hill C. J. McClain 1999 Treatment with glutathione precursor decreases cytokine activity J. Parenter. Enter. Nutr. 23 1 6
29. V. M. Victor M. Rocha M. D. L. Fuente 2003 N-acetylcysteine protects mice from lethal endotoxemia by regulating the redox state of immune cells Free Radic. Res. 37 919 929
30. P. E. Wischmeyer M. Kahana R. Wolfson H. Ren M. M. Musch E. B. Chang 2001 Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia Shock 16 398 402