Estimating disease risk associated with mutated genes in family-based designs

Human Heredity

Volumn 66, Issue 4, 2008, Pages 238-251

  Choi, Yun Hee ^a   Kopciuk, Karen A ^b   Briollais, Laurent ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b Division of Population Health and Information   (Canada)

Author keywords

Age at onset; Ascertainment correction; Efficient study designs; Likelihood methods; Penetrance function

Indexed keywords

ADULT; AGED; ARTICLE; CANADA; COLORECTAL CANCER; FAMILIAL CANCER; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC MODEL; GENETIC RISK; HETEROZYGOTE; HUMAN; INHERITANCE; MALE; MUTATIONAL ANALYSIS; PEDIGREE ANALYSIS; POPULATION BASED CASE CONTROL STUDY; POPULATION RESEARCH; PROCESS DESIGN; SIMULATION;

AGE OF ONSET; BIAS (EPIDEMIOLOGY); COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MODELS, GENETIC; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEWFOUNDLAND AND LABRADOR; PEDIGREE; PENETRANCE; RISK ASSESSMENT;

EID: 53249090239     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000143406     Document Type: Article

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