Studies on the development of new angiotensin II receptor antagonist as the treatment of hypertensives

Journal of Industrial and Engineering Chemistry

Volumn 3, Issue 1, 1997, Pages 46-50

  Jung, Kang Yeoun ^a   Lee, Kun Ho ^b  

^a Gangneung Wonju National University   (South Korea)

^b R and D Center of Cheil Jedang Corp   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 53249088129     PISSN: 1226086X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

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3. R. S. L. Chang, P. K. S. Siegl, B. V. Clineschmidt, N. B. Mantlo, P. K. Chakravarty, W. J. Greenlee, A. A. Patchett, and V. J. Lotti, "In Vitro Pharmacology of L-158809, a New Highly Potent and Selective Angiotensin II Receptor Antagonist", J. of Pham. and Experimental Therapeutics, 262, 133-144 (1992).
4. M. J. Peach, "Renin-Angioten System: Biochemistry and Mechanism of Action", Physiol. Rev., 57, 313-370 (1977).
5. Y. Furakawa, S. Kishimoto, K. Nishikawa, U.S. Patent 4,340,598 (1982); USP 4,355,040, (1982).
6. B. De, M. Winn, T. M. Zydowsky, D. J. Kerkman, J. F. DeBernardis, J. Lee, S. Buckneer, R. Warner, M. Brune, A. Hancock, T. Opgenorth, and K. Marsh, "Discovery of a Novel Class of Orally Active, Non-Peptide Angiotensin II Receptor Antagonists", J. Med. Chem., 35, 3714-3717 (1992).
7. W. A. Wisansky and S. Ansbacher; Org. Synth. III, 138 (1955).
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9. The synthetic procedure and authentic sample were obtained from Cheil Jedang Research Center. Representative method for the biphenyltetrazole bromide (BPT-Br) is described in experimental section.
10. Experimental data was obtained from the pharmacology team of Cheil Jedang Research Center.
11. Synthetic material were obtained and tested at Cheil Jedang Research Center.