Lipid metabolism: New insight into the modulatory role of apolipoprotein C-I in inflammation

Current Opinion in Lipidology

Volumn 19, Issue 4, 2008, Pages 431-432

  Plomgaard, Peter ^a   Nielsen, Lars B ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN C1; C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

BACTERIAL INFECTION; BACTERIAL OUTER MEMBRANE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHRONIC INFLAMMATION; DIABETES MELLITUS; ENDOTOXEMIA; GENE OVEREXPRESSION; GRAM NEGATIVE BACTERIUM; HOST RESISTANCE; HUMAN; IMMUNOMODULATION; INFLAMMATION; LIPID METABOLISM; MORTALITY; NONHUMAN; NOTE; OBESITY; PRIORITY JOURNAL; SEPSIS; ANIMAL; EDITORIAL; METABOLISM;

ANIMALS; APOLIPOPROTEIN C-I; CHOLESTEROL, HDL; HUMANS; INFLAMMATION;

EID: 53149150645     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e328306f0dd     Document Type: Note

References (5)

1. Berbee JF, van der Hoogt CC, Kleemann R, et al. Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis. FASEB J 2006; 20:2162-2164.
2. Schippers EF, Berbee JF, van Disseldorp IM, et al. Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery. Intensive Care Med 2008. [Epub ahead of print] This review is interesting because it provides an example of how the specific protein composition of HDL can affect the inflammatory response in humans with endotoxemia.
3. Berbee JF, Mooijaart SP, de Craen AJ, et al. Plasma apolipoprotein CI protects against mortality from infection in old age. J Gerontol A Biol Sci Med Sci 2008; 63:122-126.
4. Berbee JF, van der Hoogt CC, de Haas CJ, et al. Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis. Intensive Care Med 2008; 34:907-911.
5. Westerterp M, Berbee JF, Pires NM, et al. Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. Circulation 2007; 116:2173-2181. This review is interesting because it described a proatherogenic role of an HDL apolipoprotein that becomes apparent only after LPS stimulation.