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Volumn 19, Issue 4, 2008, Pages 405-408

Is it just paraoxonase 1 or are other members of the paraoxonase gene family implicated in atherosclerosis?

Author keywords

Antioxidant properties; Atherosclerosis; High density lipoprotein; Low density lipoprotein; Paraoxonases

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN B; APOLIPOPROTEIN E; ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; ARYLDIALKYLPHOSPHATASE 2; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID HYDROPEROXIDE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PARAOXONASE 3; PROTEIN; RECOMBINANT ENZYME; SUPEROXIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 53149114919     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e328304b64e     Document Type: Review
Times cited : (50)

References (16)
  • 1
    • 0029937118 scopus 로고    scopus 로고
    • The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family
    • Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 1996; 33:498-507.
    • (1996) Genomics , vol.33 , pp. 498-507
    • Primo-Parmo, S.L.1    Sorenson, R.C.2    Teiber, J.3    La Du, B.N.4
  • 2
    • 0035976903 scopus 로고    scopus 로고
    • Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein
    • Ng CJ, Wadleigh DJ, Gangopadhyay A, et al. Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J Biol Chem 2001; 276:44444-44449.
    • (2001) J Biol Chem , vol.276 , pp. 44444-44449
    • Ng, C.J.1    Wadleigh, D.J.2    Gangopadhyay, A.3
  • 3
    • 10644244414 scopus 로고    scopus 로고
    • The paraoxonase gene family and atherosclerosis
    • Ng CJ, Shih DM, Hama SY, et al. The paraoxonase gene family and atherosclerosis. Free Radic Biol Med 2005; 38:153-163.
    • (2005) Free Radic Biol Med , vol.38 , pp. 153-163
    • Ng, C.J.1    Shih, D.M.2    Hama, S.Y.3
  • 4
    • 0035865671 scopus 로고    scopus 로고
    • Hydrolysis of platelet-activating factor by human serum paraoxonase
    • Rodrigo LB, Mackness PN, Durrington A, et al. Hydrolysis of platelet-activating factor by human serum paraoxonase. Biochem J 2001; 354:1-7.
    • (2001) Biochem J , vol.354 , pp. 1-7
    • Rodrigo, L.B.1    Mackness, P.N.2    Durrington, A.3
  • 5
    • 0037339957 scopus 로고    scopus 로고
    • Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress
    • Rosenblat M, Draganov D, Watson CE, et al. Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. Arterioscler Thromb Vasc Biol 2003; 23:468-474.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 468-474
    • Rosenblat, M.1    Draganov, D.2    Watson, C.E.3
  • 6
    • 34247213490 scopus 로고    scopus 로고
    • Paraoxonase 2 reduced oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation
    • This study describes the potential role of PON2 in reducing oxidative stress and vascular inflammation
    • Horke S, Writte I, Wilegenbus P, et al. Paraoxonase 2 reduced oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation 2007; 115:2055-2064. This study describes the potential role of PON2 in reducing oxidative stress and vascular inflammation.
    • (2007) Circulation , vol.115 , pp. 2055-2064
    • Horke, S.1    Writte, I.2    Wilegenbus, P.3
  • 7
    • 66749175476 scopus 로고    scopus 로고
    • Bourquard N, Shih DM, Ng CJ, et al. Paraoxonases and their role in disease development and xenobiotic metabolism. In: Mackness et al., editors. Proteins and cell regulation. 6. New York: Springer; 2007. pp. 103-128. The role of PON2 and PON3 in atherosclerosis and related traits. This is an exhaustive review of all three PON genes.
    • Bourquard N, Shih DM, Ng CJ, et al. Paraoxonases and their role in disease development and xenobiotic metabolism. In: Mackness et al., editors. Proteins and cell regulation. vol. 6. New York: Springer; 2007. pp. 103-128. The role of PON2 and PON3 in atherosclerosis and related traits. This is an exhaustive review of all three PON genes.
  • 8
    • 0347753275 scopus 로고    scopus 로고
    • Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: Contributions to atherosclerosis
    • Cathcart MK. Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24:23-28.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 23-28
    • Cathcart, M.K.1
  • 9
    • 8544227651 scopus 로고    scopus 로고
    • Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation intomacrophages
    • Shiner M, Fuhrman B, Aviram M. Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation intomacrophages. Free Radic Biol Med 2004; 37:2052-2063.
    • (2004) Free Radic Biol Med , vol.37 , pp. 2052-2063
    • Shiner, M.1    Fuhrman, B.2    Aviram, M.3
  • 10
    • 33749544927 scopus 로고    scopus 로고
    • Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-b containing lipoproteins - antiatherogenic role for paraoxonase-2
    • Ng CJ, Villa N, Hama SY, et al. Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-b containing lipoproteins - antiatherogenic role for paraoxonase-2. J Biol Chem 2006; 281:29491-29500.
    • (2006) J Biol Chem , vol.281 , pp. 29491-29500
    • Ng, C.J.1    Villa, N.2    Hama, S.Y.3
  • 11
    • 0035958917 scopus 로고    scopus 로고
    • The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways
    • Fisher EA, Pan M, Chen X, et al. The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways. J Biol Chem 2001; 276:27855-27863.
    • (2001) J Biol Chem , vol.276 , pp. 27855-27863
    • Fisher, E.A.1    Pan, M.2    Chen, X.3
  • 12
    • 33751093349 scopus 로고    scopus 로고
    • Paraoxonase 2 protects against the development of atherosclerosis in apolipoprotein-E deficient mice
    • Ng CJ, Hama SY, Navab M, et al. Paraoxonase 2 protects against the development of atherosclerosis in apolipoprotein-E deficient mice. Mol Genet Metab 2006; 89:368-373.
    • (2006) Mol Genet Metab , vol.89 , pp. 368-373
    • Ng, C.J.1    Hama, S.Y.2    Navab, M.3
  • 13
    • 0034721761 scopus 로고    scopus 로고
    • Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein- associated lactonase and protects low density lipoprotein against oxidation
    • Draganov DI, Stetson PL, Watson CE, et al. Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein- associated lactonase and protects low density lipoprotein against oxidation. J Biol Chem 2000; 275:33435-33442.
    • (2000) J Biol Chem , vol.275 , pp. 33435-33442
    • Draganov, D.I.1    Stetson, P.L.2    Watson, C.E.3
  • 14
    • 0035048507 scopus 로고    scopus 로고
    • Human paraoxonase-3 is an HDL- associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids
    • Reddy ST, Wadleigh DJ, Grijalva V, et al. Human paraoxonase-3 is an HDL- associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. Arterioscler Thromb Vasc Biol 2001; 21:542-547.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 542-547
    • Reddy, S.T.1    Wadleigh, D.J.2    Grijalva, V.3
  • 15
    • 34249305527 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice
    • This study shows that transient expression of PON3 is sufficient to reduce atherosclerosis in advanced atherosclerotic lesions in apoE null mice
    • Ng CJ, Bourquard N, Villa N, et al. Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2007; 27:1368-1374. This study shows that transient expression of PON3 is sufficient to reduce atherosclerosis in advanced atherosclerotic lesions in apoE null mice.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1368-1374
    • Ng, C.J.1    Bourquard, N.2    Villa, N.3
  • 16
    • 34247590214 scopus 로고    scopus 로고
    • Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice
    • This paper not only demonstrates the athero-protective nature of PON3 in transgenic mouse models but also shows that PON3 may be an important player in obesity as well
    • Shih DM, Xia Yr, Wang XP, et al. Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Cir Res 2007; 100:1200-1207. This paper not only demonstrates the athero-protective nature of PON3 in transgenic mouse models but also shows that PON3 may be an important player in obesity as well.
    • (2007) Cir Res , vol.100 , pp. 1200-1207
    • Shih, D.M.1    Xia, Y.2    Wang, X.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.