메뉴 건너뛰기




Volumn 18, Issue 8, 2008, Pages 661-664

Intracellular glutathione plays important roles in pyrrolizidine alkaloid clivorine-induced toxicity on L-02 hepatocytes

Author keywords

Clivorine; Glutathione; Hepatotoxicity; Pyrrolizidine alkaloids

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; CLIVORINE; GLUTATHIONE; PYRROLIZIDINE ALKALOID;

EID: 53149084533     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510802205726     Document Type: Article
Times cited : (5)

References (21)
  • 1
    • 4344576889 scopus 로고    scopus 로고
    • Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: Protection by N-acetyl cysteine
    • Bajt, M. L., Knight, T. R., Lemasters, J. J., and Jaeschke, H. 2004. Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol. Sci. 80:343-349.
    • (2004) Toxicol. Sci , vol.80 , pp. 343-349
    • Bajt, M.L.1    Knight, T.R.2    Lemasters, J.J.3    Jaeschke, H.4
  • 2
    • 0016421339 scopus 로고
    • Biochemical methylations: Selected aspects
    • Cantoni, G. L. 1975. Biochemical methylations: selected aspects. Annu. Rev. Biochem. 44:435-441.
    • (1975) Annu. Rev. Biochem , vol.44 , pp. 435-441
    • Cantoni, G.L.1
  • 3
    • 24144455258 scopus 로고    scopus 로고
    • Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor-mediated toxicity
    • Chen, T., Pearce, L. L., Peterson, J., Stoyanovsky, D., and Billiar, T. R. 2005. Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor-mediated toxicity. Hepatology 42:598-607.
    • (2005) Hepatology , vol.42 , pp. 598-607
    • Chen, T.1    Pearce, L.L.2    Peterson, J.3    Stoyanovsky, D.4    Billiar, T.R.5
  • 4
    • 0037209032 scopus 로고    scopus 로고
    • Pyrrolizidine alkaloids in foods
    • Taylor, S. L, ed, Vo, Elsevier Science, Oxford, pp
    • Coulombe, R. A. 2003. Pyrrolizidine alkaloids in foods. In: Taylor, S. L. (ed.), Advances in Food and Nutrition Research, Vo. 45, Elsevier Science, Oxford, pp. 61-99.
    • (2003) Advances in Food and Nutrition Research , vol.45 , pp. 61-99
    • Coulombe, R.A.1
  • 5
    • 0026387907 scopus 로고
    • Glutathione metabolism and its role in hepatotoxicity
    • Deleve, L. D., and Kaplowitz, N. 1991. Glutathione metabolism and its role in hepatotoxicity. Pharmacol. Ther. 52:287-305.
    • (1991) Pharmacol. Ther , vol.52 , pp. 287-305
    • Deleve, L.D.1    Kaplowitz, N.2
  • 6
    • 0029932363 scopus 로고    scopus 로고
    • Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: The role of glutathione and relevance to hepatic venoocclusive disease
    • DeLeve, L. D., Wang, X., Kuhlenkamp, J. F., and Kaplowitz, N. 1996. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology 23:589-599.
    • (1996) Hepatology , vol.23 , pp. 589-599
    • DeLeve, L.D.1    Wang, X.2    Kuhlenkamp, J.F.3    Kaplowitz, N.4
  • 8
    • 0020444895 scopus 로고
    • Mechanism of actin, metabolism and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis
    • Griffith, O. W. 1982. Mechanism of actin, metabolism and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J. Biol. Chem. 257:13704-13712.
    • (1982) J. Biol. Chem , vol.257 , pp. 13704-13712
    • Griffith, O.W.1
  • 9
    • 0024595042 scopus 로고
    • Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
    • Hansen, M. B., Nielsen, S. E., and Berg, K. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119:203-210.
    • (1989) J. Immunol. Methods , vol.119 , pp. 203-210
    • Hansen, M.B.1    Nielsen, S.E.2    Berg, K.3
  • 10
    • 9944252438 scopus 로고    scopus 로고
    • Pyrrolizidine alkaloid clivorine induces apoptosis in human normal liver L-02 cells and reduces the expression of p53 protein
    • Ji, L. L., Zhang, M., Sheng, Y. C., and Wang, Z. T. 2005. Pyrrolizidine alkaloid clivorine induces apoptosis in human normal liver L-02 cells and reduces the expression of p53 protein. Toxicol. in Vitro 19:41-46.
    • (2005) Toxicol. in Vitro , vol.19 , pp. 41-46
    • Ji, L.L.1    Zhang, M.2    Sheng, Y.C.3    Wang, Z.T.4
  • 11
    • 0036891360 scopus 로고    scopus 로고
    • Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells
    • Ji, L. L., Zhao, X. G., Chen, L., Zhang, M., and Wang, Z. T. 2002. Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells. Toxicon 40:1685-1690.
    • (2002) Toxicon , vol.40 , pp. 1685-1690
    • Ji, L.L.1    Zhao, X.G.2    Chen, L.3    Zhang, M.4    Wang, Z.T.5
  • 12
    • 0032039959 scopus 로고    scopus 로고
    • Clinical application of N-acetylcysteine
    • Kelly, G. S. 1998. Clinical application of N-acetylcysteine. Alt. Med. Rev. 3:114-127.
    • (1998) Alt. Med. Rev , vol.3 , pp. 114-127
    • Kelly, G.S.1
  • 13
    • 0019310784 scopus 로고
    • Carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia Dentata
    • Kuhara, K., Takanashi, H., Hirono, I., Furuya, T., and Asada, Y. 1980. Carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia Dentata. Cancer Lett. 10:117-122.
    • (1980) Cancer Lett , vol.10 , pp. 117-122
    • Kuhara, K.1    Takanashi, H.2    Hirono, I.3    Furuya, T.4    Asada, Y.5
  • 14
    • 0033032034 scopus 로고    scopus 로고
    • Role of S-adenosyl-L-methionine in the treatment of liver diseases
    • Lieber, C. S. 1999. Role of S-adenosyl-L-methionine in the treatment of liver diseases. J. Hepatol. 30:1155-1159.
    • (1999) J. Hepatol , vol.30 , pp. 1155-1159
    • Lieber, C.S.1
  • 15
    • 0033669269 scopus 로고    scopus 로고
    • Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid
    • Lin, G., Cui, Y. Y., and Hawes, E. M. 2000. Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid. Drug Metab. Dispos. 28:1475-1483.
    • (2000) Drug Metab. Dispos , vol.28 , pp. 1475-1483
    • Lin, G.1    Cui, Y.Y.2    Hawes, E.M.3
  • 16
    • 33947721791 scopus 로고    scopus 로고
    • Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine
    • Santra, A., Chowdhury, A., Ghatak, S., Biswas, A., and Dhali, G. K. 2007. Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine. Toxicol. Appl. Pharmacol. 220:146-155.
    • (2007) Toxicol. Appl. Pharmacol , vol.220 , pp. 146-155
    • Santra, A.1    Chowdhury, A.2    Ghatak, S.3    Biswas, A.4    Dhali, G.K.5
  • 17
    • 0021288857 scopus 로고
    • Glutathione disulfide (GSSG) efflux from cells and tissues
    • Sies, H., and Akerboom, T. P. 1984. Glutathione disulfide (GSSG) efflux from cells and tissues. Method Enzymol. 105:445-451.
    • (1984) Method Enzymol , vol.105 , pp. 445-451
    • Sies, H.1    Akerboom, T.P.2
  • 18
    • 33646805713 scopus 로고    scopus 로고
    • Depletion of intracellular glutathione mediates butenolide-inudced cytotoxicity in HepG2 cells
    • Wang, Y. M., Peng, S. Q., Zhou, Q., Wang, M. W., Yan, C. H., Yang, H. Y., and Wang, G. Q. 2006. Depletion of intracellular glutathione mediates butenolide-inudced cytotoxicity in HepG2 cells. Toxicol. Lett. 164:231-238.
    • (2006) Toxicol. Lett , vol.164 , pp. 231-238
    • Wang, Y.M.1    Peng, S.Q.2    Zhou, Q.3    Wang, M.W.4    Yan, C.H.5    Yang, H.Y.6    Wang, G.Q.7
  • 19
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu, G. Y., Fang, Y. Z., Yang, S., Lupton, J. R., and Turner, N. D. 2004. Glutathione metabolism and its implications for health. J. Nutr. 134:489-492.
    • (2004) J. Nutr , vol.134 , pp. 489-492
    • Wu, G.Y.1    Fang, Y.Z.2    Yang, S.3    Lupton, J.R.4    Turner, N.D.5
  • 20
    • 2442694125 scopus 로고    scopus 로고
    • Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook
    • Xia, Q., Chou, M. W., Lin, G., and Fu, P. P. 2004. Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook. Chem. Res. Toxicol. 17:702-708.
    • (2004) Chem. Res. Toxicol , vol.17 , pp. 702-708
    • Xia, Q.1    Chou, M.W.2    Lin, G.3    Fu, P.P.4
  • 21
    • 0018667601 scopus 로고
    • Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test
    • Yamanaka, H., Nagao, M., Sugimura, T., Furuya, T., Shirai, A., and Matsushima, T. 1979. Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test. Mutat. Res. 68:211-216.
    • (1979) Mutat. Res , vol.68 , pp. 211-216
    • Yamanaka, H.1    Nagao, M.2    Sugimura, T.3    Furuya, T.4    Shirai, A.5    Matsushima, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.