Monoamine oxidase inhibitory properties of some benzazoles: Structure-; Activity relationships

AAPS Journal

Volumn 1, Issue 4, 1999, Pages

  Grandi, Teresa ^a   Sparatore, Fabio ^a   Gnerre, Carmela ^b   Crivori, Patrizia ^b   Carrupt, Pierre Alain ^b   Testa, Bernard ^b  

^a Department of Pharmaceutical Sciences   (Italy)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); BENZIMIDAZOLE DERIVATIVE; INDAZOLE DERIVATIVE; MONOAMINE OXIDASE INHIBITOR; TRIAZOLE DERIVATIVE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG SCREENING; IN VITRO STUDY; METABOLISM; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; BENZIMIDAZOLES; DRUG EVALUATION, PRECLINICAL; IN VITRO; INDAZOLES; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TRIAZOLES;

EID: 53149083747     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Shih JC. Molecular basis of human MAO A and B. Neuropsychopharm. 1991;4:l-7.
2. Gargalidis-Moudanos C, Remaury A, Parmi A. Predominant expression of monoamine oxidase B isoform in rabbit renal proximal tube: regulation by 12 imidazoline ligands in intact cells. Mol Pharmacol. 1997 ;51:637-643.
3. Castagnoli K, Palmer S, Anderson A, Bueters T, Castagnoli Jr. N. The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of l-methyl-4phenyl-1 , 2 ,3 , 6-tetrahydropyridine. Chem Res Toxicol. 1997; 10:364368.
4. Thull U, Testa B. Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases. Biochem Pharmacol. 1994;47:23072310.
5. Paglietti G, Sparatore F. Preparazione di acidi bbenzotriazolilbutirrici variamente sostituiti quali potenziali coleretici. Farmaco. 1972;27:380-396.
6. Crowther AF, Curd FHS, Davey DG, Stacey GJ. Synthetic antimalarials. Part XXXLX. Sialkylaminoalkylaminoquinolines. J Chem Soc. 1949;1260-1271.
7. Weissbach H, Smith TE, Daly JW, Witkop B, Udenfriend S. A rapid spectrophotometric assay of monoamine oxidase based on the rate of disappearance of kynuramine. J Biol Chem. 1960;235:1160-1163.
8. Thull U, Kneubühler S, Testa B, Borges MFM, Pinto MMM. Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitors. Pharm Res. 1993;10:1187-1190.
9. Dearden JC, Bresnen GM. The measurement of partition coefficients. Quant. Struct-Act Relat. 1988;7:133-144.
10. DAYLIGHT Software 4.41, Daylight Chemical Information System, Inc., Irvine, California: 1995.
11. Wouters J, Ooms F, Jegham S, Koenig JJ, George P, Durant F. Reversible inhibition of type B monoamine oxidase. Theoretical study of model diazo heterocyclic compounds. Fur J Med Chem. 1997;32:721-730.
12. Steyaert G, Lisa G, Gaillard P, Boss G, Reymond F, Girault HH, Carrupt PA, Testa B. Intermolecular forces expressed in 1,2dichloroethane/water partition coefficient: a solvatochromic analysis. J Chem Soc. 1997;93:401-406.
13. Chopineaux-Courtois V, Reymond F, Bouchard G, Carrupt PA, Testa B, Girault HH Effects of charge and of intramolecular structure on the lipophilicity of nitrophenols. J Am Chem Soc. 1999; 121:17431747.
14. Wouters J, Durant F, Champagne B, André JM. Electronic properties of flavins: implications on the reactivity and absorption properties of flavoproteins. Int J Quant Chem. 1997;64:721-733.