Colocalization of a carnosine-splitting enzyme, tissue carnosinase (CN2)/cytosolic non-specific dipeptidase 2 (CNDP2), with histidine decarboxylase in the tuberomammillary nucleus of the hypothalamus

Neuroscience Letters

Volumn 445, Issue 2, 2008, Pages 166-169

  Otani, Hiroto ^a   Okumura, Akiko ^a   Nagai, Katsuya ^a   Okumura, Nobuaki ^a  

^a BIOMOL ENG RESEARCH INSTITUTE   (Japan)

Author keywords

Carnosinase; Carnosine; CN2; CNDP2; Histamine; Tuberomammillary nucleus

Indexed keywords

CYTOSOLIC NON SPECIFIC DIPEPTIDASE 2; HISTIDINE DECARBOXYLASE; HYDROLASE; TISSUE CARNOSINASE 2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN NUCLEUS; HISTAMINE METABOLISM; HISTAMINERGIC SYSTEM; HYPOTHALAMUS TUBEROMAMMILLARY NUCLEUS; IMMUNOHISTOCHEMISTRY; NONHUMAN; POSTERIOR HYPOTHALAMUS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

ANIMALS; DIPEPTIDASES; HISTIDINE DECARBOXYLASE; NEURONS; RATS; TUBER CINEREUM;

EID: 53049108883     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.09.008     Document Type: Article

References (33)

1. Bauer K. Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain. Neurochem. Res. 30 (2005) 1339-1345
2. Bauer K., Hallermayer K., Salnikow J., Kleinkauf H., and Hamprecht B. Biosynthesis of carnosine and related peptides by glial cells in primary culture. J. Biol. Chem. 257 (1982) 3593-3597
3. Bauer K., Salnikow J., de Vitry F., Tixier-Vidal A., and Kleinkauf H. Characterization and biosynthesis of omega-aminoacyl amino acids from rat brain and the C-6 glioma cell line. J. Biol. Chem. 254 (1979) 6402-6407
4. Biffo S., Grillo M., and Margolis F.L. Cellular localization of carnosine-like and anserine-like immunoreactivities in rodent and avian central nervous system. Neuroscience 35 (1990) 637-651
5. Boldyrev A., Song R., Lawrence D., and Carpenter D.O. Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species. Neuroscience 94 (1999) 571-577
6. Bonfanti L., Peretto P., De Marchis S., and Fasolo A. Carnosine-related dipeptides in the mammalian brain. Prog. Neurobiol. 59 (1999) 333-353
7. Ericson H., Watanabe T., and Kohler C. Morphological analysis of the tuberomammillary nucleus in the rat brain: delineation of subgroups with antibody against l-histidine decarboxylase as a marker. J. Comp. Neurol. 263 (1987) 1-24
8. Guiotto A., Calderan A., Ruzza P., and Borin G. Carnosine and carnosine-related antioxidants: a review. Curr. Med. Chem. 12 (2005) 2293-2315
9. Hanson H.T., and Smith E.L. Carnosinase: an enzyme of swine kidney. J. Biol. Chem. 179 (1949) 789-801
10. Hoffmann A.M., Bakardjiev A., and Bauer K. Carnosine-synthesis in cultures of rat glial cells is restricted to oligodendrocytes and carnosine uptake to astrocytes. Neurosci. Lett. 215 (1996) 29-32
11. Kohen R., Yamamoto Y., Cundy K.C., and Ames B.N. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 3175-3179
12. Laidlaw S.A., and Kopple J.D. Newer concepts of the indispensable amino acids. Am. J. Clin. Nutr. 46 (1987) 593-605
13. Lenney J.F. Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase). Biol. Chem. Hoppe Seyler 371 (1990) 433-440
14. Lenney J.F., George R.P., Weiss A.M., Kucera C.M., Chan P.W., and Rinzler G.S. Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. Clin. Chim. Acta 123 (1982) 221-231
15. Lenz G.R., and Martell A.E. Metal complexes of carnosine. Biochemistry 3 (1964) 750-753
16. Margolis F.L. Carnosine in the primary olfactory pathway. Science 184 (1974) 909-911
17. Margolis F.L., Grillo M., Brown C.E., Williams T.H., Pitcher R.G., and Elgar G.J. Enzymatic and immunological evidence for two forms of carnosinase in the mouse. Biochim. Biophys. Acta 570 (1979) 311-323
18. Mochizuki T., Yamatodani A., Okakura K., Horii A., Inagaki N., and Wada H. Circadian rhythm of histamine release from the hypothalamus of freely moving rats. Physiol. Behav. 51 (1992) 391-394
19. Nagai K., Niijima A., Yamano T., Otani H., Okumura N., Tsuruoka N., Nakai M., and Kiso Y. Possible role of l-carnosine in the regulation of blood glucose through controlling autonomic nerves. Exp. Biol. Med. (Maywood) 228 (2003) 1138-1145
20. Niijima A., Okui T., Matsumura Y., Yamano T., Tsuruoka N., Kiso Y., and Nagai K. Effects of l-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats. Auton. Neurosci. 97 (2002) 99-102
21. Otani H., Okumura N., Hashida-Okumura A., and Nagai K. Identification and characterization of a mouse dipeptidase that hydrolyzes l-carnosine. J. Biochem. (Tokyo) 137 (2005) 167-175
22. Paxinos G., and Watson C. The Rat Brain (1998), Academic Press, New York
23. Prell G.D., and Green J.P. Histamine as a neuroregulator. Annu. Rev. Neurosci. 9 (1986) 209-254
24. Rawlings N.D., Morton F.R., Kok C.Y., Kong J., and Barrett A.J. MEROPS: the peptidase database. Nucleic Acids Res. 36 (2008) D320-D325
25. Rodriguez E.M., Blazquez J.L., Pastor F.E., Pelaez B., Pena P., Peruzzo B., and Amat P. Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int. Rev. Cytol. 247 (2005) 89-164
26. Sakurai E., Sakurai E., Oreland L., Nishiyama S., Kato M., Watanabe T., and Yanai K. Evidence for the presence of histamine uptake into the synaptosomes of rat brain. Pharmacology 78 (2006) 72-80
27. Tamaki N., Funatsuka A., Fujimoto S., and Hama T. The utilization of carnosine in rats fed on a histidine-free diet and its effect on the levels of tissue histidine and carnosine. J. Nutr. Sci. Vitaminol. (Tokyo) 30 (1984) 541-551
28. Tanida M., Gotoh H., Taniguchi H., Otani H., Shen J., Nakamura T., Tsuruoka N., Kiso Y., Okumura N., and Nagai K. Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats. Regul. Pept. 144 (2007) 62-71
29. Teufel M., Saudek V., Ledig J.P., Bernhardt A., Boularand S., Carreau A., Cairns N.J., Carter C., Cowley D.J., Duverger D., Ganzhorn A.J., Guenet C., Heintzelmann B., Laucher V., Sauvage C., and Smirnova T. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. J. Biol. Chem. 278 (2003) 6521-6531
30. Trombley P.Q., Horning M.S., and Blakemore L.J. Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection. Biochemistry (Moscow) 65 (2000) 807-816
31. Unno H., Yamashita T., Ujita S., Okumura N., Otani H., Okumura A., Nagai K., and Kusunoki M. Structural basis of mouse carnosinase CN2 for specific recognition of l-carnosine. J. Biol. Chem. 283 (2008) 27289-27299
32. Watanabe T., Taguchi Y., Shiosaka S., Tanaka J., Kubota H., Terano Y., Tohyama M., and Wada H. Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res. 295 (1984) 13-25
33. Yamano T., Niijima A., Iimori S., Tsuruoka N., Kiso Y., and Nagai K. Effect of l-carnosine on the hyperglycemia caused by intracranial injection of 2-deoxy-d-glucose in rats. Neurosci. Lett. 313 (2001) 78-82