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Volumn 17, Issue 10, 2008, Pages 1573-1580

Expert opinion on Tilarginine in the treatment of shock

Author keywords

Cardiovascular shock; L NMMA; Nitric oxide; Septic shock; Tilarginine

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INOTROPIC AGENT; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; PLACEBO;

EID: 53049108027     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.10.1573     Document Type: Article
Times cited : (14)

References (47)
  • 1
    • 0028332056 scopus 로고
    • Nitric oxide synthase inhibitors. Charachterization, purification, molecular cloning and functions
    • Forstermann U, Closs EI, Pollock JS, et al. Nitric oxide synthase inhibitors. Charachterization, purification, molecular cloning and functions. Hypertension 1994;23(6 Pt 2):1121-31
    • (1994) Hypertension , vol.23 , Issue.6 PART 2 , pp. 1121-1131
    • Forstermann, U.1    Closs, E.I.2    Pollock, J.S.3
  • 3
    • 0033789703 scopus 로고    scopus 로고
    • The inhibitory potency of arginine substrate site nitric oxide synthase inhibitors determined by their affinity towards the different isoenzymes
    • Boer R, Ulrich W, Klein T, et al. The inhibitory potency of arginine substrate site nitric oxide synthase inhibitors determined by their affinity towards the different isoenzymes. Mol Pharmacol 2000;58:1026-34
    • (2000) Mol Pharmacol , vol.58 , pp. 1026-1034
    • Boer, R.1    Ulrich, W.2    Klein, T.3
  • 4
    • 0033566683 scopus 로고    scopus 로고
    • Biological significance of endogenous methylarginines that inhibit nitric oxide synthases
    • Leiper J, Vallance P. Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc Res 1999;43(3):542-8
    • (1999) Cardiovasc Res , vol.43 , Issue.3 , pp. 542-548
    • Leiper, J.1    Vallance, P.2
  • 5
    • 35848950188 scopus 로고    scopus 로고
    • Endothelial dysfunction as an early sign of atherosclerosis
    • Giannotti G, Landmesser U. Endothelial dysfunction as an early sign of atherosclerosis. Herz 2007;32(7):568-72
    • (2007) Herz , vol.32 , Issue.7 , pp. 568-572
    • Giannotti, G.1    Landmesser, U.2
  • 6
    • 0032923525 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans
    • Mayer BX, Mensik C, Krishnaswami S, et al. Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans. Br J Clin Pharmacol 1999;47(5):539-44
    • (1999) Br J Clin Pharmacol , vol.47 , Issue.5 , pp. 539-544
    • Mayer, B.X.1    Mensik, C.2    Krishnaswami, S.3
  • 7
    • 0032892009 scopus 로고    scopus 로고
    • Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group
    • Hussein Z, Beerahee M, Grover R, et al. Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Clin Pharmacol Ther 1999;65(1):1-9
    • (1999) Clin Pharmacol Ther , vol.65 , Issue.1 , pp. 1-9
    • Hussein, Z.1    Beerahee, M.2    Grover, R.3
  • 8
    • 0031671914 scopus 로고    scopus 로고
    • Nitric oxide: An important role in the maintenance of systemic and pulmonary vascular tone in man
    • Kiely DG, Lee AF, Struthers AD, Lipworth BJ. Nitric oxide: an important role in the maintenance of systemic and pulmonary vascular tone in man. Br J Clin Pharmacol 1998;46(3):263-6
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.3 , pp. 263-266
    • Kiely, D.G.1    Lee, A.F.2    Struthers, A.D.3    Lipworth, B.J.4
  • 9
    • 0028314525 scopus 로고
    • Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans
    • Stamler JS, Loh E, Roddy MA, et al. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 1994;89(5):2035-40
    • (1994) Circulation , vol.89 , Issue.5 , pp. 2035-2040
    • Stamler, J.S.1    Loh, E.2    Roddy, M.A.3
  • 10
    • 0031967493 scopus 로고    scopus 로고
    • Haemodynamic effects of inhibition of nitric oxide synthase and of L-arginine at rest and during exercise
    • Brett SE, Cockcroft JR. Mant, TG, et al. Haemodynamic effects of inhibition of nitric oxide synthase and of L-arginine at rest and during exercise. J Hypertens 1998;16(4):429-35
    • (1998) J Hypertens , vol.16 , Issue.4 , pp. 429-435
    • Brett, S.E.1    Cockcroft, J.R.2    Mant, T.G.3
  • 11
    • 33747082828 scopus 로고    scopus 로고
    • An evidence-based approach to the management of pulmonary arterial hypertension
    • Archer SL, Michelakis ED. An evidence-based approach to the management of pulmonary arterial hypertension. Curr Opin Cardiol 2006;21(4):385-92
    • (2006) Curr Opin Cardiol , vol.21 , Issue.4 , pp. 385-392
    • Archer, S.L.1    Michelakis, E.D.2
  • 12
    • 0242441513 scopus 로고    scopus 로고
    • Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans
    • Stewart AD, Millasseau SC, Kearney MT, et al. Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans. Hypertension 2003;42(5):915-8
    • (2003) Hypertension , vol.42 , Issue.5 , pp. 915-918
    • Stewart, A.D.1    Millasseau, S.C.2    Kearney, M.T.3
  • 13
    • 33645129849 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase activity contributes to the regulation of peripheral vascular tone in patients with cirrhosis and ascites
    • Ferguson JW, Dover AF, Chia S, et al. Inducible nitric oxide synthase activity contributes to the regulation of peripheral vascular tone in patients with cirrhosis and ascites. Gut 2006;55(4):542-6
    • (2006) Gut , vol.55 , Issue.4 , pp. 542-546
    • Ferguson, J.W.1    Dover, A.F.2    Chia, S.3
  • 14
    • 0032928083 scopus 로고    scopus 로고
    • Nitric oxide in septic shock
    • Titheradge MA. Nitric oxide in septic shock. Biochim Biophys Acta 1999;1411(2-3):437-55
    • (1999) Biochim Biophys Acta , vol.1411 , Issue.2-3 , pp. 437-455
    • Titheradge, M.A.1
  • 15
    • 1642441405 scopus 로고    scopus 로고
    • Mechanisms of beta-adrenergic receptor-mediated venodilation in humans
    • Schindler C, Dobrev D, Grossmann M, et al. Mechanisms of beta-adrenergic receptor-mediated venodilation in humans. Clin Pharmacol Ther 2004;75(1):49-59
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.1 , pp. 49-59
    • Schindler, C.1    Dobrev, D.2    Grossmann, M.3
  • 16
    • 0035869591 scopus 로고    scopus 로고
    • Preservation of venous endothelial function in the forearm venous capacitance bed of patients with chronic heart failure despite arterial endothelial dysfunction
    • Nightingale AK, Blackman DJ, Ellis GR, et al. Preservation of venous endothelial function in the forearm venous capacitance bed of patients with chronic heart failure despite arterial endothelial dysfunction. J Am Coll Cardiol 2001;37(4):1062-8
    • (2001) J Am Coll Cardiol , vol.37 , Issue.4 , pp. 1062-1068
    • Nightingale, A.K.1    Blackman, D.J.2    Ellis, G.R.3
  • 17
    • 0030791770 scopus 로고    scopus 로고
    • Basal release of nitric oxide augments the Frank-Starling response in the isolated heart
    • Prendergast BD, Sagach VF, Shah AM. Basal release of nitric oxide augments the Frank-Starling response in the isolated heart. Circulation 1997;96(4):1320-9
    • (1997) Circulation , vol.96 , Issue.4 , pp. 1320-1329
    • Prendergast, B.D.1    Sagach, V.F.2    Shah, A.M.3
  • 18
    • 0034126937 scopus 로고    scopus 로고
    • Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride 546C88
    • Harrison RW, Thakkar RN, Senzaki H, et al. Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride 546C88. Crit Care Med 2000;28(5):1263-8
    • (2000) Crit Care Med , vol.28 , Issue.5 , pp. 1263-1268
    • Harrison, R.W.1    Thakkar, R.N.2    Senzaki, H.3
  • 19
    • 33745778223 scopus 로고    scopus 로고
    • Positive effects of nitric oxide on left ventricular function in humans
    • Rassaf T, Poll LW, Brouzos P, et al. Positive effects of nitric oxide on left ventricular function in humans. Eur Heart J 2006;27(14):1699-705
    • (2006) Eur Heart J , vol.27 , Issue.14 , pp. 1699-1705
    • Rassaf, T.1    Poll, L.W.2    Brouzos, P.3
  • 20
    • 0026669398 scopus 로고
    • Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart
    • Amrani M, O'Shea J, Allen NJ, et al. Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart. J Physiol 1992;456:681-7
    • (1992) J Physiol , vol.456 , pp. 681-687
    • Amrani, M.1    O'Shea, J.2    Allen, N.J.3
  • 21
    • 2342454577 scopus 로고    scopus 로고
    • Nitric oxide and cardiac muscarinic control in humans
    • Chowdhary S, Marsh AM, Coote JH, et al. Nitric oxide and cardiac muscarinic control in humans. Hypertension 2004;43(5):1023-8
    • (2004) Hypertension , vol.43 , Issue.5 , pp. 1023-1028
    • Chowdhary, S.1    Marsh, A.M.2    Coote, J.H.3
  • 22
    • 0025147512 scopus 로고
    • Loss of vascular responsiveness induced by endotoxin involves l-arginine pathway
    • Julou-Schaeffer G, Gray GA, Fleming I. Loss of vascular responsiveness induced by endotoxin involves l-arginine pathway. Am J Physiol 1990;259(4 Pt 2):H1038-43
    • (1990) Am J Physiol , vol.259 , Issue.4 PART 2
    • Julou-Schaeffer, G.1    Gray, G.A.2    Fleming, I.3
  • 23
    • 0026655617 scopus 로고
    • Interferon gamma and tumor necrosis factor synergise to induce, nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells
    • Geng YJ, Hansson GK, Holme E. Interferon gamma and tumor necrosis factor synergise to induce, nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells. Circ Res 1992;71:1268-76
    • (1992) Circ Res , vol.71 , pp. 1268-1276
    • Geng, Y.J.1    Hansson, G.K.2    Holme, E.3
  • 24
    • 28144438893 scopus 로고    scopus 로고
    • Effect of vitamin C and L-NMMA on the inotropic response to dobutamine in patients with heart failure
    • Mak S, Overgaard CB, Newton GE. Effect of vitamin C and L-NMMA on the inotropic response to dobutamine in patients with heart failure. Am J Physiol 2005;289(6):H2424-8
    • (2005) Am J Physiol , vol.289 , Issue.6
    • Mak, S.1    Overgaard, C.B.2    Newton, G.E.3
  • 25
    • 33748424136 scopus 로고    scopus 로고
    • Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans
    • Charkoudian N, Joyner MJ, Barnes SA, et al. Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans. Am J Physiol 2006;291(3):H1378-83
    • (2006) Am J Physiol , vol.291 , Issue.3
    • Charkoudian, N.1    Joyner, M.J.2    Barnes, S.A.3
  • 26
    • 18044365684 scopus 로고    scopus 로고
    • Interaction between nitric oxide and the cholinergic and sympathetic nervous system in cardiovascular control in humans
    • Sartori C, Lepori M, Scherrer U. Interaction between nitric oxide and the cholinergic and sympathetic nervous system in cardiovascular control in humans. Pharmacol Ther 2005,106(2):209-20
    • (2005) Pharmacol Ther , vol.106 , Issue.2 , pp. 209-220
    • Sartori, C.1    Lepori, M.2    Scherrer, U.3
  • 27
    • 9144220131 scopus 로고    scopus 로고
    • Glaxo Wellcome International Septic Shock Study Group. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: Results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002)
    • Bakker J, Grover R, McLuckie A, et al.; Glaxo Wellcome International Septic Shock Study Group. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med 2004;32(1):1-12
    • (2004) Crit Care Med , vol.32 , Issue.1 , pp. 1-12
    • Bakker, J.1    Grover, R.2    McLuckie, A.3
  • 28
    • 0035328214 scopus 로고    scopus 로고
    • Acetylcholine-mediated vasodilation in the forearm circulation of patients with heart failure: Indirect evidence for the role of endothelium-derived hyperpolarizing factor
    • Katz SD, Krum H. Acetylcholine-mediated vasodilation in the forearm circulation of patients with heart failure: indirect evidence for the role of endothelium-derived hyperpolarizing factor. Am J Cardiol 2001;87(9):1089-92
    • (2001) Am J Cardiol , vol.87 , Issue.9 , pp. 1089-1092
    • Katz, S.D.1    Krum, H.2
  • 29
    • 0029864356 scopus 로고    scopus 로고
    • Nitric oxide and septic shock
    • Cobb J, Danner R. Nitric oxide and septic shock. JAMA 1996;275:1192-6
    • (1996) JAMA , vol.275 , pp. 1192-1196
    • Cobb, J.1    Danner, R.2
  • 30
    • 0035940129 scopus 로고    scopus 로고
    • The pathogenesis of vasodilatory shock
    • Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med 2001;345:588-95
    • (2001) N Engl J Med , vol.345 , pp. 588-595
    • Landry, D.W.1    Oliver, J.A.2
  • 31
    • 4444273012 scopus 로고    scopus 로고
    • Multi-center, randomised, placebo-controlled double blind study of the nitric oxide inhibitor 546C: Effects on survival in patients with septic shock
    • Lopez A, Lorente JA, Steingrub J, et al. Multi-center, randomised, placebo-controlled double blind study of the nitric oxide inhibitor 546C: effects on survival in patients with septic shock. Crit Care Med 2004;32:21-30
    • (2004) Crit Care Med , vol.32 , pp. 21-30
    • Lopez, A.1    Lorente, J.A.2    Steingrub, J.3
  • 32
    • 33747087878 scopus 로고    scopus 로고
    • Pickkers P. Dorresteijn MJ, Bouw MPWJM, et al. In vitro-evidence for nitric oxide mediated calcium activated potassium channel activation during human endotoxemia. Circulation 2006; 114:414-21
    • Pickkers P. Dorresteijn MJ, Bouw MPWJM, et al. In vitro-evidence for nitric oxide mediated calcium activated potassium channel activation during human endotoxemia. Circulation 2006; 114:414-21
  • 33
    • 0032935162 scopus 로고    scopus 로고
    • Effects of cytokines on nitric oxide pathways in human vasculature
    • Bhagat K, Vallance P. Effects of cytokines on nitric oxide pathways in human vasculature. Curt Opin Nephrol Hypertens 1999;8:89-96
    • (1999) Curt Opin Nephrol Hypertens , vol.8 , pp. 89-96
    • Bhagat, K.1    Vallance, P.2
  • 34
    • 33645730404 scopus 로고    scopus 로고
    • Effect of nitric oxide synthase (NOS) inhibition on macro and microcirculation in a model of rat endotoxic shock
    • Pullamsetti SS, Mating D, Ghofrani HA, et al. Effect of nitric oxide synthase (NOS) inhibition on macro and microcirculation in a model of rat endotoxic shock. Thromb Haemostasis 2006;95:591-2
    • (2006) Thromb Haemostasis , vol.95 , pp. 591-592
    • Pullamsetti, S.S.1    Mating, D.2    Ghofrani, H.A.3
  • 35
    • 0028059160 scopus 로고
    • Nitric oxide inhibition in the treatment of the sepsis syndrome is detrimental to tissue oxygenation
    • Statman R, Cheng W, Cunningham JN, et al. Nitric oxide inhibition in the treatment of the sepsis syndrome is detrimental to tissue oxygenation. J Surg Res 1994;57(1):93-8
    • (1994) J Surg Res , vol.57 , Issue.1 , pp. 93-98
    • Statman, R.1    Cheng, W.2    Cunningham, J.N.3
  • 36
    • 0001015597 scopus 로고
    • NG-monomethyl-L-arginine HCL (L-NMMA: 546C88) improves survival in a conscious instrumented mouse model of endotoxic shock
    • Rees H, Monkhouse JE, Mocanda S. NG-monomethyl-L-arginine HCL (L-NMMA: 546C88) improves survival in a conscious instrumented mouse model of endotoxic shock. Endothelium 1995;3(Suppl 1):S116
    • (1995) Endothelium , vol.3 , Issue.SUPPL. 1
    • Rees, H.1    Monkhouse, J.E.2    Mocanda, S.3
  • 37
    • 0013604727 scopus 로고    scopus 로고
    • Treatment with the NO synthase inhibitor 546C88 twelve hours after the start of E. coli bacteraemia is beneficial in a baboon model of septic shock
    • Redl H, Schlag G, Gasser H. Treatment with the NO synthase inhibitor 546C88 twelve hours after the start of E. coli bacteraemia is beneficial in a baboon model of septic shock. Shock 1997;8(Suppl 1):51
    • (1997) Shock , vol.8 , Issue.SUPPL. 1 , pp. 51
    • Redl, H.1    Schlag, G.2    Gasser, H.3
  • 38
    • 0032990946 scopus 로고    scopus 로고
    • Am open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group
    • Grover R, Zaccardelli D, Colice G, et al. Am open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Crit Care Med 1999;27(5):913-22
    • (1999) Crit Care Med , vol.27 , Issue.5 , pp. 913-922
    • Grover, R.1    Zaccardelli, D.2    Colice, G.3
  • 39
    • 9144268892 scopus 로고    scopus 로고
    • Watson D, Grover R, Anzueto A, et al.; Glaxo Wellcome International Septic Shock Study Group. Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit. Care Med. 2004;32(1):13-20
    • Watson D, Grover R, Anzueto A, et al.; Glaxo Wellcome International Septic Shock Study Group. Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit. Care Med. 2004;32(1):13-20
  • 40
    • 0038000645 scopus 로고    scopus 로고
    • Cardiogenic shock complicating acute myocardial infarction: Expanding the paradigm
    • Hochman JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation 2003; 107(24):2998-3002
    • (2003) Circulation , vol.107 , Issue.24 , pp. 2998-3002
    • Hochman, J.S.1
  • 41
    • 0034724294 scopus 로고    scopus 로고
    • L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock
    • Cotter G, Kaluski E, Blatt A, et al. L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock. Circulation 2000;101(12):1358-61
    • (2000) Circulation , vol.101 , Issue.12 , pp. 1358-1361
    • Cotter, G.1    Kaluski, E.2    Blatt, A.3
  • 42
    • 0042405194 scopus 로고    scopus 로고
    • LINCS: L-NAME (a NO synthase inhibitor) in the treatment of refractory cardiogenic shock: a prospective randomized study
    • Cotter G, Kaluski E, Milo O, et al. LINCS: L-NAME (a NO synthase inhibitor) in the treatment of refractory cardiogenic shock: a prospective randomized study. Eur Heart J 2003;24(14):1287-95
    • (2003) Eur Heart J , vol.24 , Issue.14 , pp. 1287-1295
    • Cotter, G.1    Kaluski, E.2    Milo, O.3
  • 43
    • 34247392754 scopus 로고    scopus 로고
    • Triumph Investigators. Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled trial
    • Alexander JH, Reynolds HR, Stebbins AL, et al.; Triumph Investigators. Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA 2007;297(15):1657-66
    • (2007) JAMA , vol.297 , Issue.15 , pp. 1657-1666
    • Alexander, J.H.1    Reynolds, H.R.2    Stebbins, A.L.3
  • 44
    • 34548301578 scopus 로고    scopus 로고
    • SHould we inhibit nitric Oxide synthase in Cardiogenic shocK 2 (SHOCK-2) investigators. Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: A phase II dose-ranging study
    • Dzavik V, Cotter G, Reynolds HR, et al.; SHould we inhibit nitric Oxide synthase in Cardiogenic shocK 2 (SHOCK-2) investigators. Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. Eur Heart J 2007;28(9):1109-16
    • (2007) Eur Heart J , vol.28 , Issue.9 , pp. 1109-1116
    • Dzavik, V.1    Cotter, G.2    Reynolds, H.R.3
  • 45
    • 0031040613 scopus 로고    scopus 로고
    • 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
    • Garvey EP, Oplilnger JA, Furfine ES, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 1997-272(8):4959-63
    • J Biol Chem , vol.1997 -272 , Issue.8 , pp. 4959-4963
    • Garvey, E.P.1    Oplilnger, J.A.2    Furfine, E.S.3
  • 46
    • 34047185202 scopus 로고    scopus 로고
    • Upregulation of renal inducible nitric oxide synthase during human endotoxemia is associated with proximal tubule injury
    • Heemskirk S, Pickkers P, Bouw MP, et al. Upregulation of renal inducible nitric oxide synthase during human endotoxemia is associated with proximal tubule injury. Clin J Am Soc Nephrol 2006; 1:853-62
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 853-862
    • Heemskirk, S.1    Pickkers, P.2    Bouw, M.P.3
  • 47
    • 0034643290 scopus 로고    scopus 로고
    • A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivative
    • Naka M, Nanbu T, Kobayashi K, et al. A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivative. Biochem Biophys Res Commun 2000;270:663-7
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 663-667
    • Naka, M.1    Nanbu, T.2    Kobayashi, K.3


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