General, robust, and stereocomplementary preparation of β-ketoester enol tosylates as cross-coupling partners utilizing TsCl-N-methylimidazole agents

Organic Letters

Volumn 10, Issue 11, 2008, Pages 2131-2134

  Nakatsuji, Hidefumi ^a   Ueno, Kanako ^a   Misaki, Tomonori ^a   Tanabe, Yoo ^a  

^a KWANSEI GAKUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 53049107645     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol800480d     Document Type: Article

References (21)

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2. 3N·HCl).
3. 3N·HCl).
4. 2)].
5. 2O/pH ∼10].
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13. 50, oral, 1130 mg/kg) and DMAP (56 mg/kg)]
14. This observation resembles the precedent reports of esterification and amide formations promoted by combined bases NMI and TMEDA. (a) Nakatsuji, H.; Morita, J.; Misaki, T.; Tanabe, Y Adv. Synth. Catal. 2006, 348, 2057.
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16. NMI [δ 3.63 (s, 3H), 6.89 (s, 1H), 6.95 (s, 1H), 7.38 (s, 1H)] and A [δ 2.39 (s, 3H), 3.93 (s, 3H), 7.46-7.48(m, 2H), 7.70. (s, 1H), 8.02 (s, 1H), 8.12-8.15 (m, 2H), 11.05 (s, 1H)]. A chart was described in ESI.
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