The mu opioid receptor A118G gene polymorphism moderates effects of trait anger-out on acute pain sensitivity

Pain

Volumn 139, Issue 2, 2008, Pages 406-415

  Bruehl, Stephen ^a   Chung, Ok Y ^a   Burns, John W ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

A118G; Anger expression; Anger management style; Anger suppression; Anger in; Anger out; Genetic; Opioid; Pain

Indexed keywords

MU OPIATE RECEPTOR;

ADULT; ALLELE; ANGER; ARTICLE; BIOLOGICAL TRAIT; CONTROLLED STUDY; FEMALE; GENE; GENE INTERACTION; GENOTYPE; HUMAN; HYPERALGESIA; HYPOALGESIA; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MCGILL PAIN QUESTIONNAIRE; MU OPIATE RECEPTOR GENE; NOCICEPTION; PAIN; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPERATURE STRESS; WILD TYPE;

ADULT; ANGER; FEMALE; HUMANS; INHIBITION (PSYCHOLOGY); MALE; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID, MU;

EID: 53049107355     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2008.05.014     Document Type: Article

References (44)

1. Aiken L.S., and West S.G. Multiple regression: testing and interpreting interactions (1991), Sage, Thousand Oaks, CA
2. Baron R.M., and Kenny D.A. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51 (1986) 1173-1182
3. Beck A.T., Ward C.H., Mendelson M., Mock J.E., and Erbough J.K. An inventory for measuring depression. Arch Gen Psychiatry 4 (1961) 561-571
4. Beutler L.E., Engle D., Oro-Beutler E., Daldrup R., and Meredith K. Inability to express intense affect: a common link between depression and pain. J Consult Clin Psychol 54 (1986) 752-759
5. Bond C., LaForge K.S., Tian M., Melia D., Zhang S., Borg L., et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 95 (1998) 9608-9613
6. Bruehl S., al'Absi M., France C.R., France J., Harju A., Burns J.W., et al. Anger management style and endogenous opioid function: is gender a moderator?. J Behav Med 30 (2007) 209-219
7. Bruehl S., Burns J.W., Chung O.Y., Ward P., and Johnson B. Anger and pain sensitivity in chronic low back pain patients and pain-free controls: the role of endogenous opioids. Pain 99 (2002) 223-233
8. Bruehl S., Chung O.Y., and Burns J.W. Anger expression and pain: an overview of findings and possible mechanisms. J Behav Med 29 (2006) 593-606
9. Bruehl S., Chung O.Y., Burns J.W., and Biridepalli S. The association between anger expression and chronic pain intensity: evidence for partial mediation by endogenous opioid dysfunction. Pain 106 (2003) 317-324
10. Bruehl S., Chung O.Y., Burns J.W., and Diedrich L. Trait anger expressiveness and pain-induced beta-endorphin release: support for the opioid dysfunction hypothesis. Pain 130 (2007) 208-215
11. Bruehl S., Chung O.Y., Donahue B.S., and Burns J.W. Anger regulation style, postoperative pain, and relationship to the A118G mu opioid receptor gene polymorphism: a preliminary study. J Behav Med 29 (2006) 161-169
12. Burns J.W., and Bruehl S. Anger management style, opioid analgesic use, and chronic pain severity: a test of the opioid-deficit hypothesis. J Behav Med 28 (2005) 555-563
13. Burns J.W., Bruehl S., and Caceres C. Anger management style, blood pressure reactivity and acute pain sensitivity: evidence for a Trait × Situation model. Ann Behav Med 27 (2004) 195-204
14. Burns J.W., Johnson B.J., Mahoney N., Devine J., and Pawl R. Anger management style, hostility and spouse responses: gender differences in predictors of adjustment among chronic pain patients. Pain 64 (1996) 445-453
15. Burns J.W., Kubilus A., and Bruehl S. Emotion induction moderates effects of anger management style on acute pain sensitivity. Pain 106 (2003) 109-118
16. Chou W.Y., Wang C.H., Liu P.H., Liu C.C., Tseng C.C., and Jawan B. Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy. Anesthesiology 105 (2006) 334-337
17. Chung O.Y., Bruehl S., Diedrich L., Diedrich A., Chont M., and Robertson D. Baroreflex sensitivity associated hypoalgesia in healthy states is altered by chronic pain. Pain 138 (2008) 87-97
18. Cronbach L.J. Essentials of psychological testing (1970), Harper & Row, New York, NY
19. Fillingim R.B., and Edwards R.R. Is self-reported childhood abuse history associated with pain perception among healthy young men and women?. Clin J Pain 21 (2005) 387-397
20. Fillingim R.B., Kaplan L., Staud R., Ness T.J., Glover T.L., Campbell C.M., et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain 6 (2005) 159-167
21. Forgione A.G., and Barber T.X. A strain gauge pain stimulator. Psychophysiology 8 (1971) 102-106
22. Gelernter J., Kranzler H., and Cubells J. Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects. Mol Psychiatry 4 (1999) 476-483
23. Gelkopf M. Laboratory pain and styles of coping with anger. J Psychol 131 (1997) 121-123
24. 2 laser stimulation in subjects with fibromyalgia syndrome. Pain 58 (1994) 185-193
25. Janicki P.K., Schuler G., Francis D., Bohr A., Gordin V., Jarzembowski T., et al. A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain. Anesth Analg 103 (2006) 1011-1017
26. Kerns R.D., Rosenberg R., and Jacob M.C. Anger expression and chronic pain. J Behav Med 17 (1994) 57-67
27. Klepstad P., Rakvag T.T., Kaasa S., Holthe M., Dale O., Borchgrevink P.C., et al. The 118 A>G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand 48 (2004) 1232-1239
28. Kroslak T., LaForge S., Gianotti R.J., Ho A., Nielsen D.A., and Kreek M.J. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem 103 (2007) 77-87
29. Lautenbacher S., and Rollman G.B. Possible deficiencies of pain modulation in fibromyalgia. Clin J Pain 13 (1997) 189-196
30. Lotsch J., Skarke C., Grosch S., Darimont J., Schmidt H., and Geisslinger G. The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine. Pharmacogenetics 12 (2002) 3-9
31. Lotsch J., Skarke C., Liefhold J., and Geisslinger G. Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet 43 (2004) 983-1013
32. Lotsch J., Stuck B., and Hummel T. The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation. Behav Neurosci 120 (2006) 1218-1224
33. 2+ channels by heterologously expressed wild-type mutant human mu opioid receptors (hMORs) containing the A118G single nucleotide polymorphism. J Neurophysiol 97 (2007) 1058-1067
34. Maurset A., Skoglung L.A., Hustveit O., Klepstad P., and Oye I. A new version of the ischemic tourniquet pain test. Meth Find Exp Clin Pharmacol 13 (1992) 643-647
35. Melzack R. The short form of the McGill pain Questionnaire. Pain 30 (1987) 191-197
36. Rene M., Wan C.K.D., Wegner J.P., and Elizabeth L. Style of anger expression: Relation to expressivity, personality, and health. Person Soc Psych Bull 25 (1999) 1196-1207
37. Reyes-Gibby C.C., Shete S., Rakvag T., Bhat S.V., Skorpen F., Bruera E., et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain 130 (2007) 25-30
38. Sayar K., Gulec H., and Topbas M. Alexithymia and anger in patients with fibromyalgia. Clin Rheumatol 23 (2004) 441-448
39. Skarke C., Darimont J., Schmidt H., Geisslinger G., and Lotsch J. Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers. Clin Pharmacol Ther 73 (2003) 107-121
40. Spielberger C.D., Gorsuch R.L., and Lushene R.E. Manual for the State-Trait Anxiety Inventory (1970), Consulting Psychologists Press, Palo Alto, CA
41. Spielberger C.D., Jacobs G., Russell S., and Crane R. Assessment of anger: the State-Trait Anger Scale. In: Butcher J.N., and Spielberger C.D. (Eds). Advances in personality assessment vol. 2 (1983), LEA, Hillsdale, NJ 161-189
42. Spielberger C.D., Johnson E.H., Russell S.F., Crane R.J., Jacobs G.A., and Worden T.J. The experience and expression of anger: construction and validation of an anger expression scale. In: Chesney M.A., and Rosenman R.H. (Eds). Anger and hostility in cardiovascular and behavioral disorders (1985), Hemisphere Publishing Corp., Washington, DC 5-30
43. Tschannen T.A., Duckro P.N., Margolis R.B., and Tomazic T.J. The relationship of anger, depression, and perceived disability among headache patients. Headache 32 (1992) 501-503
44. Zhang Y., Wang D., Johnson A.D., Papp A.C., and Sadee W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 280 (2005) 32618-32624