Evidence of the neuroprotective role of citicoline in glaucoma patients

Progress in Brain Research

Volumn 173, Issue , 2008, Pages 541-554

  Parisi, Vincenzo ^a   Coppola, Giovanni ^b   Centofanti, Marco ^a,c   Oddone, Francesco ^a   Maria Angrisani, Anna ^b   Ziccardi, Lucia ^a   Ricci, Benedetto ^b   Quaranta, Luciano ^d   Manni, Gianluca ^a,c  

^a IRCCS FONDAZIONE BIETTI   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

Author keywords

citicoline; glaucoma; innermost retinal layers; pattern electroretinogram; visual evoked potentials; visual function; visual pathways

Indexed keywords

CEBROLUX; CEBROTON; CITICOLINE; UNCLASSIFIED DRUG;

ADULT; ELECTRORETINOGRAPHY; EVOKED VISUAL RESPONSE; FEMALE; GLAUCOMA; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE CONDUCTION; NEUROPROTECTION; PRIORITY JOURNAL; RETINA; REVIEW; VISUAL SYSTEM;

ADULT; CYTIDINE DIPHOSPHATE CHOLINE; ELECTRORETINOGRAPHY; EVOKED POTENTIALS, VISUAL; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; RETINA;

EID: 53049104702     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)01137-0     Document Type: Review

References (58)

1. Agnoli, A., Fioravanti, M. and Lechner, H. (1985) Efficacy of CDP-choline in chronic cerebral vascular diseases (CCVD). In: Novel Biochemical, Pharmacological and Clinical Aspects of Cytidinediphosphocholine. Proceedings of the International Meeting, Sorrento, Italy, 1984. New York: Elsevier, pp. 305-308.
2. Armington J.C. The Electroretinogram (1974), Academic Press, New York
3. Bach M. Electrophysiological approaches for early detection of glaucoma. Eur. J. Ophthalmol. 11 Suppl 2 (2001) S41-S49
4. Birbamer G., Gesterbrand E., Rainer J., and Eberhardt R. CDP-choline in the treatment of Parkinson's disease. New Trends Clin. Pharmacol. 4 (1990) 1-6
5. Boismare F., Le Poncin M., Lefrancois J., and Lecordier J.C. Action of cytidine diphosphocholine on functional and hemodynamic effects of cerebral ischemia in cats. Pharmacology 17 (1978) 15-20
6. Cacabelos R., Caamano J., Gomez M.J., Fernandez-Novoa L., Franco-Maside A., and Alvarez X.A. Therapeutic effects of CDP-choline in Alzheimer's disease. Cognition, brain mapping, cerebrovascular hemodynamics, and immune factors. Ann. N. Y. Acad. Sci. 777 (1996) 399-403
7. Campos E.C., Schiavi C., Benedetti P., Bolzani R., and Porciatti V. Effect of citicoline on visual acuity in amblyopia: preliminary results. Graefes. Arch. Clin. Exp. Ophthalmol. 233 (1995) 307-312
8. Celesia G.C., and Kaufmann D. Pattern ERG and visual evoked potentials in maculopathies and optic nerve disease. Invest. Ophthalmol. Vis. Sci. 26 (1985) 726-735
9. Celesia G.G., Bodis-Wollner I., Chatrian G.E., Harding G.F., Sokol S., and Spekreijse H. Recommended standards for electroretinograms and visual evoked potentials. Report of an IFCN committee. Electroencephalogr. Clin. Neurophysiol. 87 (1993) 421-436
10. Chaturvedi N., Hedley-Whyte E.T., and Dreyer E.B. Lateral geniculate nucleus in glaucoma. Am. J. Ophthalmol. 116 (1993) 182-188
11. Colotto A., Salgarello T., Giudiceandrea A., De Luca L.A., Coppè A., Buzzonetti L., and Falsini B. Pattern electroretinogram in treated ocular hypertension: a cross-sectional study after timolol maleate therapy. Ophthalmic Res. 27 (1995) 168-177
12. Fiorentini A., Maffei L., Pirchio M., Spinelli D., and Porciatti V. The ERG in response to alternating gratings in patients with diseases of the peripheral visual pathway. Invest. Ophthalmol. Vis. Sci. 21 (1981) 490-493
13. Garway-Heath D.F., Holder G.E., Fitzke F.W., and Hitchings R.A. Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2213-2220
14. Goracci G., Francescangeli E., Mozzi R., Porcellati S., and Porcellati G. Regulation of phospholipid metabolism by nucleotides in brain and transport of CDP-choline into brain. In: Zappia V., Kennedy E.P., Nilsson B.I., and Galletti P. (Eds). Novel Biochemical, Pharmacological and Clinical Aspects of Cytidinediphosphocholine (1985), Elsevier, New York 105-109
15. Gottlob I., Charlier J., and Reinecke R.D. Visual acuities and scotomas after one week levodopa administration in human amblyopia. Invest. Ophthalmol. Vis. Sci. 33 (1992) 2722-2728
16. Gottlob I., and Stangler-Zuschrott E. Effect of levodopa on contrast sensitivity and scotomas in human amblyopia. Invest. Ophthalmol. Vis. Sci. 31 (1990) 776-780
17. Gottlob I., Weghaupt H., Vass C., and Auff E. Effect of levodopa on the human pattern electroretinogram and pattern visual evoked potentials. Graefes. Arch. Clin. Exp. Ophthalmol. 227 (1989) 421-427
18. Graham S.L., Drance S.M., Chauhan B.C., Swindale N.V., Hnik P., Mikelberg F.S., and Douglas G.R. Comparison of psychophysical and electrophysiological testing in early glaucoma. Invest. Ophthalmol. Vis. Sci. 37 (1996) 2651-2662
19. Greenstein V.C., Seliger S., Zemon V., and Ritch R. Visual evoked potential assessment of the effects of glaucoma on visual subsystems. Vision Res. 38 (1998) 1901-1911
20. Gupta N., and Yucel Y.H. Brain changes in glaucoma. Eur. J. Ophthalmol. 13 Suppl 3 (2003) S32-S35
21. Gur M., Zeevi Y.Y., Bielik M., and Neumann E. Changes in the oscillatory potentials of the electroretinogram in glaucoma. Curr. Eye Res. 6 (1987) 457-466
22. Holder G.E. The pattern electroretinogram in anterior visual pathway dysfunction and its relationship to the pattern visual evoked potential: a personal clinical review of 743 eyes. Eye 11 (1997) 924-934
23. Horn F.K., Jonas J.B., Budde W.M., Junemann A.M., Mardin C.Y., and Korth M. Monitoring glaucoma progression with visual evoked potentials of the blue-sensitive pathway. Invest. Ophthalmol. Vis. Sci. 43 (2002) 1828-1834
24. Kakihana M., Fukuda N., Suno M., and Nagaoka A. Effects of CDP-choline on neurologic deficits and cerebral glucose metabolism in a rat model of cerebral ischemia. Stroke 19 (1988) 217-222
25. Kennedy E.P. Biosynthesis of phospholipids. Fed. Proc. 16 (1957) 847-853
26. Klistorner A.I., and Graham S.L. Early magnocellular loss in glaucoma demonstrated using the pseudorandomly stimulated flash visual evoked potential. J. Glaucoma 8 (1999) 140-148
27. Leguire L.E., Rogers G.L., Bremer D.L., Walson P.D., and McGregor M.L. Levodopa/carbidopa for childhood amblyopia. Invest. Ophthalmol. Vis. Sci. 34 (1993) 3090-3095
28. Maffei L., and Fiorentini A. Electroretinographic responses to alternating gratings in the cat. Exp. Brain Res. 48 (1982) 327-334
29. Martus P., Korth M., Horn F., Junemann A., Wisse M., and Jonas J.B. A multivariate sensory model in glaucoma diagnosis. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1567-1574
30. Parisi V. Neural conduction in the visual pathways in ocular hypertension and glaucoma. Graefes. Arch. Clin. Exp. Ophthalmol. 235 (1997) 136-142
31. Parisi V. Impaired visual function in glaucoma. Clin. Neurophysiol. 112 (2001) 351-358
32. Parisi V. Correlation between morphological and functional retinal impairment in patients affected by ocular hypertension, glaucoma, demyelinating optic neuritis and Alzheimer's disease. Semin. Ophthalmol. 18 (2003) 50-57
33. Parisi V. Electrophysiological assessment of glaucomatous visual dysfunction during treatment with cytidine-5′-diphosphocholine (citicoline): a study of 8 years of follow-up. Doc. Ophthalmol. 110 (2005) 91-102
34. Parisi V., and Bucci M.G. Visual evoked potentials after photostress in patients with primary open-angle glaucoma and ocular hypertension. Invest. Ophthalmol. Vis. Sci. 33 (1992) 436-442
35. Parisi V., Colacino G., Milazzo G., Scuderi A.C., and Manni G. Effects of nicergoline on the retinal and cortical electrophysiological responses in glaucoma patients: a preliminary open study. Pharmacol. Res. 40 (1999) 249-255
36. Parisi V., Manni G., Centofanti M., Gandolfi S.A., Olzi D., and Bucci M.G. Correlation between optical coherence tomography, pattern electroretinogram, and visual evoked potentials in open-angle glaucoma patients. Ophthalmology 108 (2001) 905-912
37. Parisi V., Manni G., Colacino G., and Bucci M.G. Cytidine-5′-diphosphocholine (citicoline) improves retinal and cortical responses in patients with glaucoma. Ophthalmology 106 (1999) 1126-1134
38. Parisi V., Manni G., Gandolfi S.A., Centofanti M., Colacino G., and Bucci M.G. Visual function correlates with nerve fiber layer thickness in eyes affected by ocular hypertension. Invest. Ophthalmol. Vis. Sci. 40 (1999) 1828-1833
39. Parisi V., Manni G., Spadaro M., Colacino G., Restuccia R., Marchi S., Bucci M.G., and Pierelli F. Correlation between morphological and functional retinal impairment in multiple sclerosis patients. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2520-2527
40. Parisi V., Miglior S., Manni G., Centofanti M., and Bucci M.G. Clinical ability of pattern electroretinograms and visual evoked potentials in detecting visual dysfunction in ocular hypertension and glaucoma. Ophthalmology 113 (2006) 216-228
41. Parisi V., Pernini C., Guinetti C., Neuschuler R., and Bucci M.G. Electrophysiological assessment of visual pathways in glaucoma. Eur. J. Ophthalmol. 7 (1997) 229-235
42. Pecori-Giraldi J., Virno M., Covelli G., Grechi G., and De Gregorio F. Therapeutic value of citicoline in the treatment of glaucoma (computerized and automated perimetric investigation). Int. Ophthalmol. 13 (1989) 109-112
43. Porciatti V., Falsini B., Brunori S., Colotto A., and Moretti G. Pattern electroretinogram as a function of spatial frequency in ocular hypertension and early glaucoma. Doc. Ophthalmol. 65 (1987) 349-355
44. Porciatti V., Schiavi C., Benedetti P., Baldi A., and Campos E.C. Cytidine-5′-diphosphocholine improves visual acuity, contrast sensitivity and visually-evoked potentials of amblyopic subjects. Curr. Eye Res. 17 (1998) 141-148
45. Rejdak R., Toczolowski J., Kurkowski J., Kaminski M.L., Rejdak K., Stelmasiak Z., and Grieb P. Oral citicoline treatment improves visual pathway function in glaucoma. Med. Sci. Monit. 9 (2003) PI24-PI28
46. Salgarello T., Colotto A., Falsini B., Buzzonetti L., Cesari L., Iarossi G., and Scullica L. Correlation of pattern electroretinogram with optic disc cup shape in ocular hypertension. Invest. Ophthalmol. Vis. Sci. 40 (1999) 1989-1997
47. Secades J.J., and Frontera G. CDP-choline: pharmacological and clinical review. Methods Find Exp. Clin. Pharmacol. 17 Suppl B (1995) 1-54
48. Serra I., Alberghina M., Viola M., Ristretta A., and Giuffrida A.M. Effect of CDP-choline on the biosynthesis of nucleic acids and proteins in brain regions during hypoxia. Neurochem. Res. 6 (1981) 607-618
49. Vaegan G.S.L., Goldberg I., Buckland L., and Hollows F.C. Flash and pattern electroretinogram changes with optic atrophy and glaucoma. Exp. Eye Res. 60 (1995) 697-706
50. Ventura L.M., and Porciatti V. Restoration of retinal ganglion cell function in early glaucoma after intraocular pressure reduction: a pilot study. Ophthalmology 112 (2005) 20-27
51. Ventura L.M., Porciatti V., Ishida K., Feuer W.J., and Parrish II R.K. Pattern electroretinogram abnormality and glaucoma. Ophthalmology 112 (2005) 10-19
52. Virno M., Pecori-Giraldi J., Liguori A., and De Gregorio F. The protective effect of citicoline on the progression of the perimetric defects in glaucomatous patients (perimetric study with a 10-year follow-up). Acta Ophthalmol. Scand. 232 Suppl (2000) 56-57
53. Watanabe I., Iijima H., and Tsukahara S. The pattern electroretinogram in glaucoma: an evaluation by relative amplitude from the Bjerrum area. Br. J. Ophthalmol. 73 (1989) 131-135
54. Weber A.J., Chen H., Hubbard W.C., and Kaufman P.L. Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1370-1379
55. Weiss G.B. Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci. 56 (1995) 637-660
56. Yucel Y.H., Zhang Q., Gupta N., Kaufman P.L., and Weinreb R.N. Loss of neurons in magnocellular and parvocellular layers of the lateral geniculate nucleus in glaucoma. Arch. Ophthalmol. 118 (2000) 378-384
57. Yucel Y.H., Zhang Q., Weinreb R.N., Kaufman P.L., and Gupta N. Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog. Retin. Eye Res. 22 (2003) 465-481
58. In: Zappia V., Kennedy P., Nilsson B.I., and Galletti P. (Eds). Novel Biochemical, Pharmacological and Clinical Aspects of Cytidine-diphosphocholine (1985), Elsevier, New York