Searching for New Clues in Inflammatory Bowel Disease: Tell Tales From Pediatric IBD Natural History Studies

Gastroenterology

Volumn 135, Issue 4, 2008, Pages 1038-1041

  Kugathasan, Subra ^a   Cohen, Stanley ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Children's Center for Digestive Health Care   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; IMMUNOMODULATING AGENT;

CHILD; COLITIS; CROHN DISEASE; DISEASE SEVERITY; EDITORIAL; ENTERITIS; HUMAN; INTESTINE OBSTRUCTION; INTESTINE PERFORATION; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; RELAPSE;

EID: 53049098879     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.08.030     Document Type: Editorial

References (20)

1. Hait E., Bousvaros A., and Grand R. Pediatric inflammatory bowel disease: what children can teach adults. Inflamm Bowel Dis 11 (2005) 519-527
2. Hyams J.S., and Markowitz J.F. Can we alter the natural history of Crohn disease in children?. J Pediatr Gastroenterol Nutr 40 (2005) 262-272
3. Hyams J., Crandall W., Kugathasan S., et al. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children. Gastroenterology 132 (2007) 863-873
4. Gupta N., Cohen S.A., Bostrom A.G., et al. Risk factors for initial surgery in pediatric patients with Crohn's disease. Gastroenterology 130 (2006) 1069-1077
5. Kugathasan S., Saubermann L.J., Smith L., et al. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut 56 (2007) 1696-1705
6. Dubinsky M.C., Kugathasan S., Mei L., et al. Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clin Gastroenterol Hepatol (2008) Jul 9 [Epub ahead of print]
7. Van Limbergen J., et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology 135 (2008) 1114-1122
8. Vernier-Massouille, et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology 135 (2008) 1106-1113
9. Heyman M.B., Kirschner B.S., Gold B.D., et al. Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr 146 (2005) 35-40
10. Levine A., Kugathasan S., Annese V., et al. Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility. Inflamm Bowel Dis 13 (2007) 1509-1515
11. Hyams J.S., Davis P., Grancher K., et al. Clinical outcome of ulcerative colitis in children. J Pediatr 129 (1996) 81-88
12. Kugathasan S., Judd R.H., Hoffmann R.G., et al. Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr 143 (2003) 525-531
13. Hyams J., Markowitz J., Lerer T., et al. The natural history of corticosteroid therapy for ulcerative colitis in children. Clin Gastroenterol Hepatol 4 (2006) 1118-1123
14. Cominelli F. Early and late gut immune responses in IBD. J Pediatr Gastroenterol Nutr 46 Suppl 1 (2008) E20
15. Rivera-Nieves J., Ho J., Bamias G., et al. Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis. Gastroenterology 131 (2006) 1518-1529
16. Damen G., et al. Production of IL-12p70 and IL-23 by monocyte-derived dendritic cells in children with inflammatory bowel disease. Gut 57 (2008) 1480
17. Barrett J.C., Hansoul S., Nicolae D.L., et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40 (2008) 955-962
18. Fisher S.A., Tremelling M., Anderson C.A., et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet 40 (2008) 710-712
19. Franke A., Balschun T., Karlsen T.H., et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet 40 (2008) 713-715
20. Kugathasan S., et al. A Loci on 20q13 and 21q22 are associated with in Pediatric-Onset inflammatory bowel disease. Nat Genet (2008) Aug 31 [ePub ahead of print]