Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study

Clinical Therapeutics

Volumn 30, Issue 9, 2008, Pages 1629-1638

  Lamarre Cliche, Maxime ^a   Souich, Patrick du ^b   Champlain, Jacques de ^a   Larochelle, Pierre ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

drug therapy; midodrine; neurocardiogenic syncope; orthostatic hypotension

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; AMATINE; ATRIAL NATRIURETIC FACTOR; DESGLYMIDODRINE; MIDODRINE; NEUROHORMONE; NORADRENALIN; PLACEBO; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; ADULT; AREA UNDER THE CURVE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE MEASUREMENT; CATECHOLAMINE BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; ELECTROCARDIOGRAPHY; HEART RATE VARIABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OSCILLOMETRY; PHARMACODYNAMICS; PHARMACOKINETICS; POWER SPECTRUM; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; SYNCOPE; SYSTOLIC BLOOD PRESSURE; TIME TO MAXIMUM PLASMA CONCENTRATION; VENOUS RETURN;

ADULT; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; HEART RATE; HUMANS; HYPOTENSION, ORTHOSTATIC; MALE; MIDODRINE; NATRIURETIC PEPTIDES; NOREPINEPHRINE; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SYMPATHOMIMETICS; SYNCOPE, VASOVAGAL;

EID: 53049097713     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2008.09.001     Document Type: Article

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