Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist

Journal of Biological Chemistry

Volumn 283, Issue 35, 2008, Pages 23811-23818

  Haugaard Jönsson, Linda M ^a   Hossain, Mohammed Akhter ^b   Daly, Norelle L ^c   Bathgate, Ross A D ^b   Wade, John D ^b   Craik, David J ^c   Rosengren, K Johan ^a  

^a LINNAEUS UNIVERSITY   (Sweden)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BINDING ENERGY; HORMONES; LIGANDS; NUCLEAR MAGNETIC RESONANCE; PEPTIDES;

BIOLOGICAL FUNCTIONS; CHIMERIC PEPTIDES; CONFORMATIONAL CHANGES; COUPLED RECEPTORS; ENDOGENOUS RECEPTORS; IN VIVO STUDIES; NEUROLOGICAL SIGNALING; PEPTIDE HORMONES; RECEPTOR BINDING SITES; SELECTIVE LIGANDS; SOLUTION STRUCTURES; STRUCTURAL INSIGHTS;

BINDING SITES;

AGENTS AFFECTING PROTEIN METABOLISM; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 135; G PROTEIN COUPLED RECEPTOR 135 AGONIST; G PROTEIN COUPLED RECEPTOR 142; G PROTEIN COUPLED RECEPTOR 142 AGONIST; INSL 5 PROTEIN; LGR7 RECEPTOR; MEMBRANE PROTEIN; NEUROPEPTIDE; RELAXIN 3; UNCLASSIFIED DRUG; HYBRID PROTEIN; INSULIN; LEYDIG INSULIN LIKE PROTEIN; LEYDIG INSULIN-LIKE PROTEIN; PEPTIDE; PROTEIN; RECEPTOR; RELAXIN; RLN3 PROTEIN, HUMAN; RXFP1 PROTEIN, HUMAN; RXFP3 PROTEIN, HUMAN; RXFP4 PROTEIN, HUMAN;

ARTICLE; BETA CHAIN; BINDING SITE; CHIMERA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; CHEMISTRY; DRUG POTENTIATION; HUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

BINDING SITES; HUMANS; INSULIN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RECOMBINANT FUSION PROTEINS; RELAXIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53049094251     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800489200     Document Type: Article

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