Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix

Channels

Volumn 1, Issue 3, 2007, Pages 189-197

  Rosenhouse Dantsker, Avia ^a   Logothetis, Diomedes E ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Gating; GIRK4; Kir34; Potassium channels

Indexed keywords

ASPARAGINE; ASPARTIC ACID; G PROTEIN BETA GAMMA; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G-PROTEIN BETA GAMMA; GLUTAMIC ACID; GLUTAMINE; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; LYSINE; POTASSIUM; PROTEIN SUBUNIT; SERINE; THREONINE;

ANIMAL; ARTICLE; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENE TRANSFER; GENETICS; HUMAN; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; OOCYTE; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; ASPARAGINE; ASPARTIC ACID; CELL MEMBRANE; COMPUTER SIMULATION; CONSERVED SEQUENCE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GENE TRANSFER TECHNIQUES; GLUTAMIC ACID; GLUTAMINE; GLYCINE; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; ION CHANNEL GATING; LYSINE; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTATION; OOCYTES; POTASSIUM; PROTEIN CONFORMATION; PROTEIN SUBUNITS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE; XENOPUS;

EID: 53049090685     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.4475     Document Type: Article

References (26)

1. Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. The open pore conformation of potassium channels. Nature 2002; 417:523-6.
2. Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW, Sanchez R, Logothetis DE. The subunits of G proteins gate a K+ channel by pivoted bending of a transmembrane segment. Molecular Cell 2002; 10:469-81.
3. Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R. X-ray structure of a voltage-K1 channel. Nature 2003; 423:33-41.
4. Magidovich E, Yifrach O. Conserved gating hinge in ligand- and voltage-dependent K+ channels. Biochemistry 2004; 43:13242-7.
5. Zhao Y, Yarov-Yarovoy V, Scheuer T, Catterall WA. A gating hinge in Na+ channels; a molecular switch for electrical signaling. Neuron 2004; 41:859-65.
6. Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 2003; 300:1922-6.
7. Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 1987; 325:321-6.
8. Reuveny E, Slesinger PA, Inglese J, Morales JM, Iniguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY. Activation of the cloned muscarinic potassium channel by G protein subunits. Nature 1994; 370:143-6.
9. Sui JL, Chan KW, Langan MN, Vivaudou M, Logothetis DE. G protein gated potassium channels. Adv Second Messenger Phosphoprotein Res 1999; 33:179-201.
10. Kubo Y, Reuveny E, Slesinger PA, Jan YN, Jan LY. Primary structure and functional expression of a rat G-protein- coupled muscarinic potassium channel. Nature 1993; 364:802-6.
11. Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP. Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett 1994; 353:37-42.
12. Dascal N. Signaling via the G protein-activated K+ channels. Cell Signal 1997; 9:551-73.
13. Yamada M, Inanobe A, Kurachi YG. Protein regulation of potassium ion channels. Pharmacological Reviews 1998; 50:723-57.
14. Krapivinsky G, Gordon EA, Wickman K, Velimirovic B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K+-channel proteins. Nature 1995; 374:135-41.
15. Vivaudou M, Chan KW, Sui JL, Jan LY, Reuveny E, Logothetis DE. Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants. J Biol Chem 1997; 272:31553-60.
16. Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R. The structure of the potassium channel: Molecular basis of K+ conduction and selectivity. Science 1998; 280:69-77.
17. Perozo E, Cortes DM, Cuello LG. Structural rearrangements underlying K+-channel activation gating. Science 1999; 285:73-8.
18. Liu YS, Sompornpisut P, Perozo E. Structure of the KcsA channel intracellular gate in the open state. Nat Struct Biol 2001; 8:883-7.
19. Yifrach O, MacKinnon R. Energetics of pore opening in a voltage-gated K+ channel. Cell 2002; 111:231-9.
20. Rosenhouse-Dantsker A, Logthetis DE. A new role for glycine in the pivoted bending mechanism of potassium channel gating. Biophys J 2006; 91:2860-73.
21. Domene C, Doyle DA, Venien-Bryan C. Modeling of an ion channel in its open conformation. Biophys J 2005; 89:L01-3.
22. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations. J Comp Chem 1983; 4:187-217.
23. Chan KW, Sui JL, Vivaudou M, Logothetis DE. Specific regions of heteromeric subunits involved in enhancement of G protein-gated K+ channel activity. J Biol Chem 1997; 272:6548-55.
24. He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE. Identification of critical residues controlling G protein-gated inwardly rectifying K+ channel activity through interactions with the subunits of G proteins. J Biol Chem 2002; 277:6088-96.
25. He C, Zhang H, Mirshahi T, Logothetis DE. Identification of a potassium channel site that interacts with G Protein subunits to mediate agonist-induced signaling. J Biol Chem 1999; 274:12517-24.
26. Alagem N, Yesylevskyy S, Reuveny E The pore region links fast and slow gating in inwardly rectifying potassium channels. Biophys J 2002; 85:300-12