Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor

Brain Research

Volumn 1236, Issue , 2008, Pages 140-144

  Frassetto, Andrea ^a   Zhang, Jiaping ^a   Lao, Julie Z ^a   White, Amanda ^a   Metzger, Joseph M ^a   Fong, Tung M ^a   Chen, Richard Z ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

5 HT6 receptor; Body weight; Diet induced obesity; Food intake

Indexed keywords

SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; DIET; FEEDING BEHAVIOR; FEMALE; LIPID DIET; LIPID STORAGE; LOW FAT DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; BODY COMPOSITION; BODY WEIGHT; DIETARY FATS; EATING; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; OBESITY; RECEPTORS, SEROTONIN; WEIGHT GAIN;

MUS;

EID: 53049090185     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.08.012     Document Type: Article

References (25)

1. Bence K.K., Delibegovic M., Xue B., Gorgun C.Z., Hotamisligil G.S., Neel B.G., and Kahn B.B. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat. Med. 12 (2006) 917-924
2. Bonasera S.J., Chu H.M., Brennan T.J., and Tecott L.H. A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology 31 (2006) 1801-1813
3. 6 receptor in the rat brain: a study using antisense oligonucleotides. J. Pharmacol. Exp. Ther. 274 (1995) 173-180
4. 6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 25 (2001) 662-668
5. 125I]SB-258585. Synapse 45 (2002) 191-199
6. Halford J.C., Harrold J.A., Lawton C.L., and Blundell J.E. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr. Drug Target 6 (2005) 201-213
7. Halpern A., and Mancini M.C. Treatment of obesity: an update on anti-obesity medications. Obes. Rev. 4 (2003) 25-42
8. 6 receptors. Neuropsychopharmacology 21 (1999) 68S-76S
9. 6 receptor ligands: Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacol. Ther. 117 (2008) 207-231
10. 6 serotonin receptor. J. Neurochem. 66 (1996) 47-56
11. 6 receptors: a novel target for cognitive enhancement. Pharmacol. Ther. 108 (2005) 320-333
12. 6 receptor antagonists promote sleep in rats. Sleep 31 (2008) 34-44
13. Palczewski K., Kumasaka T., Hori T., Behnke C.A., Motoshima H., Fox B.A., Le Trong I., Teller D.C., Okada T., Stenkamp R.E., Yamamoto M., and Miyano M. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289 (2000) 739-745
14. 6 receptor antagonist. J. Med. Chem. 46 (2003) 1273-1276
15. 125I]SB-258585. Brain Res. 934 (2002) 49-57
16. 6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology (Berl) 158 (2001) 114-119
17. 6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochem. Biophys. Res. Commun. 193 (1993) 268-276
18. 6 expression in the rat: functional studies using antisense oligonucleotides. Behav. Brain Res. 73 (1996) 245-248
19. 6 receptor antagonist. Pharmacol. Biochem. Behav. 71 (2002) 645-654
20. Tecott L.H. Serotonin and the orchestration of energy balance. Cell Metab. 6 (2007) 352-361
21. 6 receptor knockout mouse. United States Patent 6060642.
22. Ward R.P., Hamblin M.W., Lachowicz J.E., Hoffman B.J., Sibley D.R., and Dorsa D.M. Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry. Neuroscience 64 (1995) 1105-1111
23. 6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology 41 (2001) 210-219
24. 6 receptors. Curr. Drug Targets CNS Neurol. Disord. 3 (2004) 59-79
25. 6 receptor. Eu. J. Pharmacol. 534 (2006) 77-82