Is Chlamydia-infected tubal fimbria the origin of ovarian cancer?

Medical Hypotheses

Volumn 71, Issue 5, 2008, Pages 690-693

  Carvalho, Jesus Paula ^a   Carvalho, Filomena Marino ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

SIGNAL PEPTIDE;

ARTICLE; CARCINOGENESIS; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CHRONIC INFLAMMATION; FIMBRIA; HEALING; HUMAN; INFLAMMATION; NEOPLASM; OVARY CANCER; OVARY CARCINOMA; OVARY TUMOR; PERITONEUM; PRIORITY JOURNAL; SALPINGECTOMY; SALPINGITIS;

CHLAMYDIA; CHLAMYDIA INFECTIONS; EPITHELIUM; FALLOPIAN TUBES; FEMALE; HUMANS; INFLAMMATION; MODELS, BIOLOGICAL; MODELS, THEORETICAL; OVARIAN NEOPLASMS;

CHLAMYDIA; CHLAMYDIA TRACHOMATIS;

EID: 52949151535     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.06.028     Document Type: Article

References (22)

1. Nusbaum R., and Isaacs C. Management updates for women with a BRCA1 or BRCA2 mutation. Mol Diagn Ther 11 (2007) 133-144 Review
2. Dehari R., Kurman R.J., Logani S., and Shih IeM. The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis. Am J Surg Pathol 31 (2007) 1007-1012
3. Crum C.P., Drapkin R., Kindelberger D., Medeiros F., Miron A., and Lee Y. Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer. Clin Med Res 5 (2007) 35-44 Review
4. Shih H.A., Couch F.J., Nathanson K.L., et al. BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic. J Clin Oncol 20 (2002) 994-999
5. Carcangiu M.L., Peissel B., Pasini B., Spatti G., Radice P., and Manoukian S. Incidental carcinomas in prophylactic specimens in BRCA 1 and BRCA 2 germ-line mutation carriers, with emphasis on fallopian tube lesions. Report of six cases and review of the literature. Am J Surg Pathol 30 (2006) 1222-1230
6. Callahan M.J., Crum C.P., Medeiros F., et al. Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction. J Clin Oncol 25 (2007) 3985-3990
7. Carcangiu M.L., Radice P., Manoukian S., et al. Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers. Int J Gynecol Pathol 23 (2004) 35-40
8. Jarboe E.A., Folkins A.K., Drapkin R., Ince T.A., Agoston E.S., and Crum C.P. Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective. Histopathology 30 (2008) 230-236 10.1111/j.1365-2559.2007.02938.x
9. Medeiros F., Muto M.G., Lee Y., et al. The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome. Am J Surg Pathol 30 (2006) 230-236
10. Lee Y., Miron A., Drapkin R., et al. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol 211 (2007) 26-35
11. Hold G.L., and El-Omar M.E. Genetic aspects of inflammation and cancer. Biochem J 410 (2008) 225-235
12. Ness B.R., and Cottreau C. Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer I 91 (1999) 1459-1467
13. Landen Jr. C.N., Birrer M.J., and Sood A.K. Early events in the pathogenesis of epithelial ovarian cancer. J Clin Oncol 26 (2008) 995-1005
14. Cooper M.D., Rapp J., Jeffery-Wiseman C., Barnes R.C., and Stephens D.S. Chlamydia trachomatis infection of human fallopian tube organ cultures. J Gen Microbiol 136 (1990) 1109-1115
15. Brunham R.C., and Peeling R.W. Chlamydia trachomatis antigens: role in immunity and pathogenesis. Infect Agent Dis 3 (1994) 218-233
16. Eckert L.O., Hawes S.E., Wolner-Hanssen P., et al. Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. J Infect Dis 175 (1997) 1453-1458
17. Peeling R.W., Kimani J., Plummer F., et al. Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease. J Infect Dis 175 (1997) 1153-1158
18. Ness R.R., Goodman M.T., Shen C., and Brunham R.C. Serologic evidence of past infection with Chlamydia trachomatis, in relation to ovarian cancer. J Infect Dis 187 (2003) 1147-1152
19. Quirk J.T., and Kupinski J.M. Chronic infection, inflammation, and epithelial ovarian cancer. Med Hypotheses 57 (2001) 426-428
20. Maluf F.C., Carvalho J.P., Carvalho F.M., Schütz F.A., and Feher O. Aggressive multimodality treatment in transitional cell carcinoma of the parafallopian tube: report of two cases and review of the literature. Gynecol Oncol 102 (2006) 381-385
21. Schiffman M., Castle P.E., Jeronimo J., Rodriguez A.C., and Wacholder S. Human papillomavirus and cervical cancer. Lancet 370 9590 (2007) 890-907
22. Nunobe S., Nakanishi Y., Taniguchi H., et al. Two distinct pathways of tumorigenesis of adenocarcinomas of the esophagogastric junction, related or unrelated to intestinal metaplasia. Pathol Int 57 (2007) 315-321