Effects of intranasal TNFα on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitis

Respiratory Research

Volumn 9, Issue , 2008, Pages

  Widegren, Henrik ^a   Erjefält, Jonas ^b   Korsgren, Magnus ^a   Andersson, Morgan ^a   Greiff, Lennart ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; EOSINOPHIL CATIONIC PROTEIN; INTERLEUKIN 8; PEROXIDASE; RNASE3 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BIOPSY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOLOGY; DRUG EFFECT; EOSINOPHIL; FEMALE; GRANULOCYTE; HAY FEVER; HUMAN; INTRANASAL DRUG ADMINISTRATION; MALE; METABOLISM; MIDDLE AGED; NEUTROPHIL; NOSE MUCOSA; NOSE MUCUS; PATHOLOGY; PATHOPHYSIOLOGY; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ADMINISTRATION, INTRANASAL; ADULT; ALPHA-MACROGLOBULINS; BIOPSY; CROSS-OVER STUDIES; EOSINOPHIL CATIONIC PROTEIN; EOSINOPHILS; FEMALE; GRANULOCYTES; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; NASAL LAVAGE FLUID; NASAL MUCOSA; NEUTROPHILS; PEROXIDASE; PNEUMONIA; RHINITIS, ALLERGIC, SEASONAL; SINGLE-BLIND METHOD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 52949123471     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-9-15     Document Type: Article

References (25)

1. Olsen NJ, Stein CM. New drugs for rheumatoid arthritis. N Engl J Med 2004, 350(21):2167-2179. 10.1056/NEJMra032906, 15152062.
2. Gosset P, Tsicopoulos A, Wallaert B, Joseph M, Capron A, Tonnel AB. Tumor necrosis factor alpha and interleukin-6 production by human mononuclear phagocytes from allergic asthmatics after IgE-dependent stimulation. Am Rev Respir Dis 1992, 146(3):768-774.
3. Costa JJ, Matossian K, Resnick MB, Beil WJ, Wong DT, Gordon JR, Dvorak AM, Weller PF, Galli SJ. Human eosinophils can express the cytokines tumor necrosis factor-alpha and macrophage inflammatory protein-1 alpha. J Clin Invest 1993, 91(6):2673-2684. 443331, 8514874.
4. Finotto S, Ohno I, Marshall JS, Gauldie J, Denburg JA, Dolovich J, Clark DA, Jordana M. TNF-alpha production by eosinophils in upper airways inflammation (nasal polyposis). J Immunol 1994, 153(5):2278-2289.
5. Ackerman V, Marini M, Vittori E, Bellini A, Vassali G, Mattoli S. Detection of cytokines and their cell sources in bronchial biopsy specimens from asthmatic patients. Relationship to atopic status, symptoms, and level of airway hyperresponsiveness. Chest 1994, 105(3):687-696. 10.1378/chest.105.3.687, 8131526.
6. Devalia JL, Campbell AM, Sapsford RJ, Rusznak C, Quint D, Godard P, Bousquet J, Davies RJ. Effect of nitrogen dioxide on synthesis of inflammatory cytokines expressed by human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol 1993, 9(3):271-278.
7. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, Heusser CH, Howarth PH, Holgate ST. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994, 10(5):471-480.
8. Gordon JR, Galli SJ. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature 1990, 346(6281):274-276. 10.1038/346274a0, 2374592.
9. Thomas PS, Heywood G. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma. Thorax 2002, 57(9):774-778. 10.1136/thorax.57.9.774, 12200521.
10. Thomas PS, Yates DH, Barnes PJ. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med 1995, 152(1):76-80.
11. Howarth PH, Babu KS, Arshad HS, Lau LC, Buckley MG, McConnell W, Beckett P, Ali MA, Chauhan A, Wilson SJ, et al. Tumour Necrosis Factor (TNF{alpha}) as a novel therapeutic target in symptomatic corticosteroid-dependent asthma. Thorax 2005,
12. Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, Bradding P, Brightling CE, Wardlaw AJ, Pavord ID. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 2006, 354(7):697-708. 10.1056/NEJMoa050580, 16481637.
13. Bensch GW, Nelson HS, Borish LC. Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistamines. Ann Allergy Asthma Immunol 2002, 88(5):457-462. 1283081, 12027065.
14. Bradding P, Mediwake R, Feather IH, Madden J, Church MK, Holgate ST, Howarth PH. TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis. Clin Exp Allergy 1995, 25(5):406-415. 10.1111/j.1365-2222.1995.tb01071.x, 7553243.
15. Ying S, Robinson DS, Varney V, Meng Q, Tsicopoulos A, Moqbel R, Durham SR, Kay AB, Hamid Q. TNF alpha mRNA expression in allergic inflammation. Clin Exp Allergy 1991, 21(6):745-750. 10.1111/j.1365-2222.1991.tb03205.x, 1777835.
16. Widegren H, Korsgren M, Andersson M, Greiff L. Effects of TNFalpha on the human nasal mucosa in vivo. Respir Med 2007, 101(9):1982-1987. 10.1016/j.rmed.2007.04.005, 17532197.
17. Persson CG, Erjefalt JS, Greiff L, Andersson M, Erjefalt I, Godfrey RW, Korsgren M, Linden M, Sundler F, Svensson C. Plasma-derived proteins in airway defence, disease and repair of epithelial injury. Eur Respir J 1998, 11(4):958-970. 10.1183/09031936.98.11040958, 9623704.
18. Greiff L, Pipkorn U, Alkner U, Persson CG. The 'nasal pool' device applies controlled concentrations of solutes on human nasal airway mucosa and samples its surface exudations/secretions. Clin Exp Allergy 1990, 20(3):253-259. 10.1111/j.1365-2222.1990.tb02680.x, 2364306.
19. Svensson C, Andersson M, Persson CG, Venge P, Alkner U, Pipkorn U. Albumin, bradykinins, and eosinophil cationic protein on the nasal mucosal surface in patients with hay fever during natural allergen exposure. J Allergy Clin Immunol 1990, 85(5):828-833. 10.1016/0091-6749(90)90064-B, 2332562.
20. Akerlund A, Greiff L, Andersson M, Bende M, Alkner U, Persson CG. Mucosal exudation of fibrinogen in coronavirus-induced common colds. Acta Otolaryngol 1993, 113(5):642-648. 10.3109/00016489309135878, 8266793.
21. Corne JM, Lau L, Scott SJ, Davies R, Johnston SL, Howarth PH. The relationship between atopic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection. Am J Respir Crit Care Med 2001, 163(5):1101-1107.
22. Klemens C, Rasp G, Jund F, Hilgert E, Devens C, Pfrogner E, Kramer MF. Mediators and cytokines in allergic and viral-triggered rhinitis. Allergy Asthma Proc 2007, 28(4):434-441. 10.2500/aap.2007.28.3017, 17883911.
23. Kyan-Aung U, Haskard DO, Poston RN, Thornhill MH, Lee TH. Endothelial leukocyte adhesion molecule-1 and intercellular adhesion molecule-1 mediate the adhesion of eosinophils to endothelial cells in vitro and are expressed by endothelium in allergic cutaneous inflammation in vivo. J Immunol 1991, 146(2):521-528.
24. Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MA. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol 1985, 135(3):2069-2073.
25. He J, Wang T, Yao L, Chen A, Zhou B, Yu H, Jia R, Cheng C, Huan L, Zhang Z. Construction and delivery of gene therapy vector containing soluble TNFalpha receptor-IgGFc fusion gene for the treatment of allergic rhinitis. Cytokine 2006, 36(5-6):296-304. 10.1016/j.cyto.2007.02.010, 17379534.