Impact of clinical varicocele and testis size on seminal reactive oxygen species levels in a fertile population: a prospective controlled study

Fertility and Sterility

Volumn 90, Issue 4, 2008, Pages 1103-1108

  Cocuzza, Marcello ^a,b   Athayde, Kelly S ^b   Agarwal, Ashok ^b   Pagani, Rodrigo ^a   Sikka, Suresh C ^c   Lucon, Antonio M ^a   Srougi, Miguel ^a   Hallak, Jorge ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b LERNER RESEARCH INSTITUTE   (United States)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

male infertility; Normal fertility; reactive oxygen species; testis volume; varicocele

Indexed keywords

REACTIVE OXYGEN METABOLITE;

ADULT; ARTICLE; CONTROLLED STUDY; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MALE FERTILITY; MALE INFERTILITY; OUTCOME ASSESSMENT; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SEMEN ANALYSIS; TESTIS SIZE; VARICOCELE;

ADULT; FERTILITY; HUMANS; INFERTILITY, MALE; MALE; ORGAN SIZE; REACTIVE OXYGEN SPECIES; SEMEN; TESTIS; VARICOCELE;

EID: 52949119970     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.07.1377     Document Type: Article

References (32)

1. Sylora J.A., and Pryor J.L. Varicocele. Curr Ther Endocrinol Metab 5 (1994) 309-314
2. Greenberg S.H., Lipshultz L.I., and Wein A.J. Experience with 425 subfertile male patients. J Urol 119 (1978) 507-510
3. World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 3rd ed (1992), Cambridge University Press, Cambridge, UK
4. Pinto K.J., Kroovand R.L., and Jarow J.P. Varicocele related testicular atrophy and its predictive effect upon fertility. J Urol 152 (1994) 788-790
5. Naughton C.K., Nangia A.K., and Agarwal A. Pathophysiology of varicoceles in male infertility. Hum Reprod Update 7 (2001) 473-481
6. Pasqualotto F.F., Rossi-Ferragut L.M., Rocha C.C., Iaconelli Jr. A., Ortiz V., and Borges Jr. E. The efficacy of repeat percutaneous epididymal sperm aspiration procedures. J Urol 169 (2003) 1779-1781
7. Sharma R.K., and Agarwal A. Role of reactive oxygen species in male infertility. Urology 48 (1996) 835-850
8. Saleh R.A., Agarwal A., Sharma R.K., Said T.M., Sikka S.C., and Thomas Jr. A.J. Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril 80 (2003) 1431-1436
9. Hendin B.N., Kolettis P.N., Sharma R.K., Thomas Jr. A.J., and Agarwal A. Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J Urol 161 (1999) 1831-1834
10. Prader A. Testicular size: assessment and clinical importance. Triangle 7 (1966) 240-243
11. World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed (1999), Cambridge University Press, Cambridge, UK
12. Kruger T.F., Acosta A.A., Simmons K.F., Swanson R.J., Matta J.F., and Oehninger S. Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil Steril 49 (1988) 112-117
13. Shekarriz M., Sharma R.K., Thomas Jr. A.J., and Agarwal A. Positive myeloperoxidase staining (Endtz test) as an indicator of excessive reactive oxygen species formation in semen. J Assist Reprod Genet 12 (1995) 70-74
14. Shekarriz M., Thomas Jr. A.J., and Agarwal A. Incidence and level of seminal reactive oxygen species in normal men. Urology 45 (1995) 103-107
15. Uehling D.T. Fertility in men with varicocele. Int J Fertil 13 (1968) 58-60
16. Thomason A.M., and Fariss B.L. The prevalence of varicoceles in a group of healthy young men. Mil Med 144 (1979) 181-182
17. Lund L., and Larsen S.B. A follow-up study of semen quality and fertility in men with varicocele testis and in control subjects. Br J Urol 82 (1998) 682-686
18. Lipshultz L.I., and Corriere Jr. J.N. Progressive testicular atrophy in the varicocele patient. J Urol 117 (1977) 175-176
19. Fariss B.L., Fenner D.K., Plymate S.R., Brannen G.E., Jacob W.H., and Thomason A.M. Seminal characteristics in the presence of a varicocele as compared with those of expectant fathers and prevasectomy men. Fertil Steril 35 (1981) 325-327
20. de Castro M.P., and Mastrorocco D.A. Reproductive history and semen analysis in prevasectomy fertile men with and without varicocele. J Androl 5 (1984) 17-20
21. Witt M.A., and Lipshultz L.I. Varicocele: a progressive or static lesion?. Urology 42 (1993) 541-543
22. Fretz P.C., and Sandlow J.I. Varicocele: current concepts in pathophysiology, diagnosis, and treatment. Urol Clin North Am 29 (2002) 921-937
23. The Practice Committee of the American Society for Reproductive Medicine. Report on varicocele and infertility. Fertil Steril 86 Suppl 5 (2006) S93-S95
24. Allamaneni S.S., Naughton C.K., Sharma R.K., Thomas Jr. A.J., and Agarwal A. Increased seminal reactive oxygen species levels in patients with varicoceles correlate with varicocele grade but not with testis size. Fertil Steril 82 (2004) 1684-1686
25. Athayde K.S., Cocuzza M., Agarwal A., Krajcir N., Lucon A.M., Srougi M., et al. Development of normal reference values for seminal reactive oxygen species and their correlation with leukocytes and semen parameters in a fertile population. J Androl 28 (2007) 613-620
26. Agarwal A., Allamaneni S.S., and Said T.M. Chemiluminescence technique for measuring reactive oxygen species. Reprod Biomed Online 9 (2004) 466-468
27. Zini A., and Libman J. Sperm DNA damage: clinical significance in the era of assisted reproduction. CMAJ 175 (2006) 495-500
28. The Practice Committee of the American Society for Reproductive Medicine. The clinical utility of sperm DNA integrity testing. Fertil Steril 86 Suppl 5 (2006) S35-S37
29. Zini A., Blumenfeld A., Libman J., and Willis J. Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity. Hum Reprod 20 (2005) 1018-1021
30. Mostafa T., Anis T.H., El-Nashar A., Imam H., and Othman I.A. Varicocelectomy reduces reactive oxygen species levels and increases antioxidant activity of seminal plasma from infertile men with varicocele. Int J Androl 24 (2001) 261-265
31. Jarow J.P., Sharlip I.D., Belker A.M., Lipshultz L.I., Sigman M., Thomas A.J., et al. Best practice policies for male infertility. J Urol 167 (2002) 2138-2144
32. Prabakaran S., Kumanov P., Tomova A., Hubaveshki S., and Agarwal A. Adolescent varicocele: association with somatometric parameters. Urol Int 77 (2006) 114-117