Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors

Oncogene

Volumn 27, Issue 43, 2008, Pages 5753-5758

  Manenti, G ^a   Trincucci, G ^a   Pettinicchio, A ^a   Amendola, E ^b,c   Scarfo M ^b,c   Dragani, T A ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b STAZIONE ZOOLOGICA ANTON DOHRN   (Italy)

^c Grande Ospedale Metropolitano   (Italy)

Author keywords

Genetic susceptibility; Heredity; Lung cancer; Mouse

Indexed keywords

CIS ACTING ELEMENT; K RAS PROTEIN; PAS1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; URETHAN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CANCER MODEL; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; CROSSING OVER; EXPERIMENTAL MODEL; FEMALE; GENE LOCUS; GENE MUTATION; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY; LUNG CARCINOGENESIS; LUNG CARCINOMA; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; PRIORITY JOURNAL; WILD TYPE;

ADENOMA; ANIMALS; CHROMOSOME MAPPING; FEMALE; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; LUNG; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MUTATION; PROTO-ONCOGENE PROTEINS P21(RAS);

MUS;

EID: 52949111500     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.194     Document Type: Article

References (24)

1. Chen B, You L, Wang Y, Stoner GD, You M. (1994). Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens. Carcinogenesis 15: 2031-2035.
2. De Gregorio L, Manenti G, Incarbone M, Pilotti S, Pastorino U, Pierotti MA et al. (1998). Prognostic value of loss of heterozygosity and KRAS2 mutations in lung adenocarcinoma. Int J Cancer 79: 269-272.
3. Dragani TA, Hirohashi S, Juji T, Kawajiri K, Kihara M, Ono-Kihara M et al. (2000). Population-based mapping of pulmonary adenoma susceptibility 1 (PAS1)locus. Cancer Res 60: 5017-5020.
4. Dragani TA, Manenti G, Pierotti MA. (1995). Genetics of murine lung tumors. Adv Cancer Res 67: 83-112.
5. Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E et al. (1997). K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev 11: 2468-2481.
6. Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, Tuveson DA et al. (2001). Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410: 1111-1116.
7. Jones-Bolin SE, Johansson E, Palmisano WA, Anderson MW, Wiest JS, Belinsky SA. (1998). Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression. Carcinogenesis 19: 1503-1508.
8. Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T et al. (1997). K-ras is essential for the development of the mouse embryo. Oncogene 15: 1151-1159.
9. Maher J, Baker DA, Manning M, Dibb NJ, Roberts IA. (1995). Evidence for cell-specific differences in transformation by N-, H- and K-ras. Oncogene 11: 1639-1647.
10. Manenti G, Dragani TA. (2005). Pas1 haplotype-dependent genetic predisposition to lung tumorigenesis in rodents: a meta-analysis. Carcinogenesis 26: 875-882.
11. Manenti G, Falvella FS, Gariboldi M, Dragani TA, Pierotti MA. (1995). Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2. Genomics 29: 438-444.
12. Manenti G, Galbiati F, Giannì Barrera R, Pettinicchio A, Acevedo A, Dragani TA. (2004). Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Oncogene 23: 4495-4504.
13. Manenti G, Galbiati F, Pettinicchio A, Spinola M, Piconese S, Leoni VP et al. (2006). A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. Carcinogenesis 27: 1386-1390.
14. Maronpot RR, Palmiter RD, Brinster RL, Sandgren EP. (1991). Pulmonary carcinogenesis in transgenic mice. Exp Lung Res 17: 305-320.
15. Mascaux C, Iannino N, Martin B, Paesmans M, Berghmans T, Dusart M et al. (2005). The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis. Br J Cancer 92: 131-139.
16. Meuwissen R, Linn SC, van der Valk M, Mooi WJ, Berns A. (2001). Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene. Oncogene 20: 6551-6558.
17. Ogawa K, Imaida K, Masui T, Kawabe M, Hasegawa R, Kato K et al. (1996). Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis 17: 341-345.
18. Potenza N, Vecchione C, Notte A, De Rienzo A, Rosica A, Bauer L et al. (2005). Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep 6: 432-437.
19. To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. (2006). A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat Genet 38: 926-930.
20. Tomisawa M, Suemizu H, Ohnishi Y, Maruyama C, Urano K, Usui T et al. (2003).Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice. Toxicol Lett 142: 111-117.
21. Umemura T, Kodama Y, Hioki K, Inoue T, Nomura T, Kurokawa Y. (1999). Susceptibility to urethane carcinogenesis of transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice)and its modification by butylhydroxytoluene. Cancer Lett 145: 101-106.
22. Wang M, Futamura M, Wang Y, You M. (2005). Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Oncogene 24: 1958-1963.
23. You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds SH et al. (1992). Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids. Proc Natl Acad Sci USA 89: 5804-5808.
24. Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y et al. (2003). Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proc Natl Acad Sci USA 100: 12642-12647.