A novel autoantibody in patients with primary hypertension: Antibody against L-type Ca2+ channel

Chinese Medical Journal

Volumn 121, Issue 16, 2008, Pages 1513-1517

  Zhou, Zi Hua ^a   Wang, Jun ^a   Xiao, Hua ^a   Chen, Zhi Jian ^a   Wang, Min ^a   Cheng, Xiang ^a   Liao, Yu Hua ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Autoantibody; L type Ca2+ channel; Primary hypertension

Indexed keywords

ALPHA 1C CALCIUM CHANNEL L TYPE ANTIGEN; ANTIGEN; AUTOANTIBODY; CALCIUM CHANNEL L TYPE ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SEQUENCE; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIASTOLIC DYSFUNCTION; ELECTROCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE SIZE; HEART VENTRICLE WALL; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PREVALENCE;

EID: 52949110910     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200808020-00003     Document Type: Article

References (30)

1. Catterall WA, Perez-Reyes E, Snutch TP, Striessing J. International Union of Pharmacology XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev 2005; 57: 411-425.
2. Bodi I, Mikala G, Koch SE, Akhter SA, Schwartz A. The L-type calcium channel in the heart: the beat goes on. J Clin Invest 2005; 115: 3306-3317.
3. Nelson MT, Patlak JB, Worley JF, Standen NB. Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. Am J Physiol 1990; 259: C3-C18.
4. Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, et al. Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. Embo J 2003; 22: 6027-6034.
5. 2+ currents in small mesenteric artery myocytes from Wistar-Kyoto and spontaneously hypertensive rats. Hypertension 1997; 29: 1329-1336.
6. 2+ channels in mesenteric and skeletal arteries of SHR. Hypertension 2002; 40: 214-219.
7. 2+ channels: is membrane depolarization the signal? Circ Res 2004; 94: e97-e104.
8. Fu ML, Herlitz H, Wallukat G, Hilme E, Hedner T, Hoebeke J, et al. Functional autoimmune epitope on alpha 1-adrenergic; receptors in patients with malignant hypertension. Lancet 1994; 344: 1660-1663.
9. Wallukat CA, Blasig IE, Morwinski R, Herrmann HJ, Rohde E. The sera of spontaneously hypertensive rats contain agonistic auto-antibodies against the beta 1-adrenoceptor. J Hypertens 1995; 13: 1031-1036.
10. Luther HP, Hormith V, Willukat G. Alpha 1-adrenergic receptor antibodies in patients with primary hypertension. Hypertension 1997; 29: 678-682.
11. Fu ML, Herlitz; H, Schulze W, Wallukat G, Micke P, Eftekhari P. et al. Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. J Hypertens 2000; 18: 945-953.
12. Liao YH, Wei YM, Wang M, Wang ZH, Yuan HT, Cheng LX. Autoantibodies against AT1-receptor and alpha1-adrenergic receptor in patients with hypertension. Hypertens Res 2002; 25: 641-646.
13. 2+ channels exposed to serum from patients with type I diabetes. Science 1993; 261: 86-90.
14. Jackson MW, Gordon TP, Waterman SA. Disruption of intestinal motility by a calcium channel-stimulating autoantibody in type 1 diabetes. Gastroenterology 2004; 126: 819-828.
15. Komai K, Iwasa Y, Takamori M. Calcium channel peptide can cause an autoimmune-mediated model of Lambert-Eaton myasthenic syndrome in rats. J Neurol Sci 1999; 166: 126-130.
16. Schulze K, Heineman FW, Schultheiss UP, Balaban RS. Impairment of myocardial calcium homeostasis by antibodies against the adenine nucleatide translocator. Cell Calcium 1999; 25: 361-370.
17. Zhou Z, Liao YH, Wei Y, Wei F, Wang B, Li L, et al. Cardiac remodeling after long-term stimulation by antibodies against the alpha1-adrenergic receptor in rats. Clin Immunol 2005; 114: 164-173.
18. Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, et al. Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 2004; 113: 1419-1429.
19. Li ZZ, Liao YH, Zhou ZH, Wei YM, Wang M, Zhu F, et al. Autoantibodies against alpha1 adrenergic receptor related with cardiac remodeling in hypertensive patients by clinical observation. Chin J Cardiol (Chin) 2006; 34: 602-604.
20. Wan EC, Gordon TP, Jackson MW. Autoantibody-mediated bladder dysfunction in type 1 diabetes. Scand J Immunol 2007; 65: 70-75.
21. 2+ channels in resistance arteries from spontaneously hypertensive rats. Circ Res 1993; 73: 1090-1099.
22. Cox RH, Lozinskaya IM. Augmented calcium currents in mesenteric artery branches of the spontaneously hypertensive rat. Hypertension 1995; 26: 1060-1064.
23. Ebringer A, Doyle AE. Raised serum IgG levels in hypertension. Br Med J 1970; 2: 146-148.
24. Liu HR, Zhao RR, Jiao XY, Wang YY, Fu M. Relationship of myocardial remodeling to the genesis of serum autoantibodies to cardiac beta(1)-adrenoceptors and muscarinic: type 2 acetylcholine receptors in rats. J Am Coll Cardiol 2002; 39: 1866-1873.
25. Schultheiss HP, Kuhl U, Janda, I, Melzner B, Ulrich G, Morad M. Antibody-mediated enhancement of calcium permeability in cardiac myocytes. J Exp Med 1988; 168: 2105-2119.
26. Boutjdir M, Chen L, Zhang ZH, Tseng CE, DiDonato F, Rashbaum W, et al. Arrhythmogenicity of IgG and anti-52-kD SSA/Ro affinity purified antibodies from mothers of children with congenital heart block Circ Res 1997; 80: 354-362.
27. Xiao GQ, Hu Y, Boutjdir M. Direct inhibition of expressed cardiac 1- and t-type calcium channels by igg from mothers whose children have congenital heart block. Circulation 2001; 103: 1599-1604.
28. Hilme E, Hansson L, Sandberg L, Soderstrom T, Herlitz H. Abnormal immune function in malignant hypertension. J Hypertens 1993; 11: 989-994.
29. Lefkos N, Boura P, Boudonas G, Zacharioudald E, Efthimiadis A, Tsougas M. et al. Immunopathogenic mechanisms in hypertension. Am J Hypertens 1995; 8: 1141-1145.
30. Shao J, Nangaku M, Miyata T, Inagi R, Yamada K, Kurokawa K, et al. Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury. Hypertension 2003; 42: 31-38.