Bevacizumab sterility in multiple doses from a single-use vial

Annals of Pharmacotherapy

Volumn 42, Issue 10, 2008, Pages 1425-1428

  Örnek, Kemal ^a,c   Karahan, Zeynep Ceren ^b   Ergin, Ahmet ^a   Tekeli, Alper ^b   Tekeli, Ova ^b  

^a KIRIKKALE UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c Kinkkale University ^*  (Turkey)

Author keywords

Bevacizumab; Multidose; Single use vial; Sterility

Indexed keywords

BEVACIZUMAB;

ARTICLE; BACTERIAL GROWTH; BACTERIUM CONTAMINATION; DRUG CONTAMINATION; DRUG PACKAGING; DRUG STERILITY; DRUG STORAGE; PRIORITY JOURNAL;

ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL; BACTERIA; DRUG CONTAMINATION; DRUG PACKAGING; DRUG STORAGE; FUNGI; RESEARCH DESIGN; STERILIZATION; TEMPERATURE; TIME FACTORS;

EID: 52949109234     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1L270     Document Type: Article

References (9)

1. Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
2. Iturralde D, Spaide RF, Meyerle CB, et al. Intravitreal bevacizumab (Avastin) treatment of macular edema in central retinal vein occlusion: a short-term study. Retina 2006;26:279-84.
3. Silva Paula J, Jorge R, Alves Costa R, Rodriques Mde L, Scott IU. Short-term results of intravitreal bevacizumab (Avastin) on anterior segment neovascularization in neovascular glaucoma. Acta Ophthalmol Scand 2006;84:556-7.
4. Haritoglou C, Kook D, Neubauer A, et al. Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema. Retina 2006;26:999-1005.
5. Yoganathan P, Deramo VA, Lai JC, Tibrewala RK, Fastenberg DM. Visual improvement following intravitreal bevacizumab (Avastin) in exudative age-related macular degeneration. Retina 2006;26:994-8.
6. Bakri SJ, Snyder MR, Pulido JS, McCannel CA, Weiss WT, Singh RJ. Six-month stability of bevacizumab (Avastin) binding to vascular endothelial growth factor after withdrawal into a syringe and refrigeration or freezing. Retina 2006;26:519-22.
7. Fung AE, Rosenfeld PJ, Reichel E. The International Intravitreal Bevacizumab Safety Survey: using the Internet to assess drug safety worldwide. Br J Ophthalmol 2006;90:1344-9. Epub 19 Jul 2006.
8. Avastin, INN-bevacizumab. www.emea.europa.eu/humandocs/PDFs/EPAR/avastin/ 17199204en6.pdf (accessed 2006 Jan 24).
9. Peters S, Julien S, Heiduschka P, et al. Antipermeability and antiproliferative effects of standard and frozen bevacizumab on choroidal endothelial cells. Br J Ophthalmol 2007;91:827-31.